STING nuclear partners contribute to innate immune signaling responses

Autor: Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer

Publikováno v: iScience, Vol 24, Iss 9, Pp 103055- (2021)

Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of

Externí odkaz: https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e

Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

Autor: Eleanor Gaunt, Helen M Wise, Huayu Zhang, Lian N Lee, Nicky J Atkinson, Marlynne Quigg Nicol, Andrew J Highton, Paul Klenerman, Philippa M Beard, Bernadette M Dutia, Paul Digard, Peter Simmonds

Publikováno v: eLife, Vol 5 (2016)

Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleo

Externí odkaz: https://doaj.org/article/28937b5695ef427589e8844caadf5f30

TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway

Autor: Nila Roy Choudhury, Ivan Trus, Gregory Heikel, Magdalena Wolczyk, Jacek Szymanski, Agnieszka Bolembach, Rute Maria Dos Santos Pinto, Nikki Smith, Maryia Trubitsyna, Eleanor Gaunt, Paul Digard, Gracjan Michlewski

Publikováno v: Choudhury, N R, Trus, I, Heikel, G, Wolczyk, M, Szymanski, J, Bolembach, A, Dos santos pinto, R M, Smith, N, Trubitsyna, M, Gaunt, E, Digard, P & Michlewski, G 2022, ' TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkac512
Roy Choudhury, N, trus, I, Heikel, G, Wolczyk, M, Szymanski, J, Bolembach, A, Dos Santos Pinto, R M, Smith, N, Trubitsyna, M, Gaunt, E, Digard, P & Michlewski, G 2022, ' TRIM25 inhibits influenza A virus infection, destabilises viral mRNA, but is redundant for activating the RIG-I pathway ', Nucleic Acids Research, vol. 50, no. 12, pp. 7097-7114 . https://doi.org/10.1093/nar/gkac512

The E3 ubiquitin ligase TRIM25 is a key factor in the innate immune response to RNA viruses. TRIM25 has been shown to play a role in the retinoic-acid-inducible gene-1 (RIG-I) pathway, which triggers expression of type 1 interferons upon viral infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0436a24b5e6b20022dd685abfc472163
https://doi.org/10.1093/nar/gkac512

Engineering a Vaccine Platform using Rotavirus A to Express SARS-CoV-2 Spike Epitopes

Autor: Ola Diebold, Victoria Gonzalez, Luca Venditti, Colin Sharp, Rosemary A. Blake, Joanne Stevens, Sarah Caddy, Paul Digard, Alexander Borodavka, Eleanor Gaunt

Human rotavirus (RV) vaccines used worldwide have been developed using live attenuated platforms. The recent development of a reverse genetics system for RVs has delivered the possibility of engineering chimeric viruses expressing heterologous peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d607501279ff31144d4b38d61314ddf6
https://doi.org/10.1101/2022.03.23.485570

TRIM25 inhibits Influenza A infection by destabilising its mRNA and is redundant for the RIG-I pathway

Autor: Gregory Heikel, Paul Digard, Eleanor Gaunt, Rute Maria Pinto, Maryia Trubitsyna, Ivan Trus, Nila Roy Choudhury, Gracjan Michlewski

The E3 ubiquitin ligase TRIM25 is a key factor in the innate immune response to RNA viruses. TRIM25 has been shown to play a role in the retinoic-acid-inducible gene-1 (RIG-I) pathway, which triggers expression of type 1 interferons upon viral infect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb287176862537d3d8ae54a931c58f1f
https://doi.org/10.1101/2021.09.13.460052