Výsledky vyhledávání - "Eleanor D. Kennedy"

Networks offer new opportunities for diabetes research

Autor: Azeem Majeed, David R. Matthews, Paul Chester, Eleanor D Kennedy, Paul Wallace

The incidence of diabetes continues to rise and demands on healthcare resources continue to grow. High quality research offers a way forward for developing new treatments and care options for people with this condition. The Diabetes Research Network

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6338020dd9899fb7a3e77ddb9aa1639
https://doi.org/10.1016/j.pcd.2009.10.002

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Do clinical research networks work? The NIHR diabetes research network after 6 years

Autor: David R. Matthews, Eleanor D Kennedy

Publikováno v: Clinical Investigation. 2:971-974

Clinical research in the UK has been boosted over the past decade thanks to the creation of a number of dedicated clinical research networks. Each of these facilitates the conduct of trials from both the academic and commercial sectors. The National

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b351e63699cd5ffbc7b21ec8e8f3ab64
https://doi.org/10.4155/cli.12.92

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Bariatric surgery: a European perspective

Autor: Carel W. le Roux, George Alberti, Eleanor D Kennedy

Publikováno v: European Diabetes Nursing. 9:22-25

Health care systems around the world are being stretched by pressing needs to cater for populations that are becoming more and more overweight and obese. Obesity is associated with substantial morbidity and mortality rates and, although dietary and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::803aedb62d090fc904c1de85bddc7d38
https://doi.org/10.1002/edn.199

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Clinical research networks in diabetes: the evolving role of the research nurse

Autor: S Hynd, Matthews, Eleanor D Kennedy, P Chester

Publikováno v: European Diabetes Nursing. 4:10-13

The importance of evidence-based care for patients with diabetes is well established, and the evidence required to make decisions about patient care is generated through research and audit. The rigours of the research process and the need to enrol la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::094615ffbdf8258356c11fff0ae9a742
https://doi.org/10.1002/edn.69

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NIHR Diabetes Research Network: the gold standard for clinical trials?

Autor: Eleanor D Kennedy, David R. Matthews

Publikováno v: Practical Diabetes. 29:317-319

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f47e572cbf6b10ad98601fece8d8ba0
https://doi.org/10.1002/pdi.1714

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Secretagogues Modulate the Calcium Concentration in the Endoplasmic Reticulum of Insulin-secreting Cells

Autor: Tullio Pozzan, Pierre Maechler, Angela Valeva, Claes B. Wollheim, Eleanor D. Kennedy, Elisabeth Sebö

Publikováno v: Journal of Biological Chemistry. 274:12583-12592

The precise regulation of the Ca2+ concentration in the endoplasmic reticulum ([Ca2+]er) is important for protein processing and signal transduction. In the pancreatic beta-cell, dysregulation of [Ca2+]er may cause impaired insulin secretion. The Ca2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36b291538bc7f431db28213116ddeab0
https://doi.org/10.1074/jbc.274.18.12583

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Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells

Autor: Pierre Maechler, Eleanor D. Kennedy, Claes B. Wollheim

Publikováno v: Diabetes. 47:374-380

Mitochondrial dysfunction due to alterations in the mitochondrial genome (mtDNA) has recently attracted much attention, with the finding that mutations in the mitochondrially encoded proteins perturb cell function. Several disorders have been linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0ce1b7abe91997530c3b74f17a6105
https://doi.org/10.2337/diabetes.47.3.374

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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells

Autor: Pierre Maechler, Eleanor D. Kennedy, Tullio Pozzan, Claes B. Wollheim

Publikováno v: The EMBO Journal. 16:3833-3841

In the pancreatic beta-cell, insulin secretion is stimulated by glucose metabolism resulting in membrane potential-dependent elevation of cytosolic Ca2+ ([Ca2+]c). This cascade involves the mitochondrial membrane potential (delta psi[m]) hyperpolariz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7487626fb99d24170a84691607f84b
https://doi.org/10.1093/emboj/16.13.3833

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