Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Eleanor D, Lamming"'
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol
Autor:
Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes
Publikováno v:
Frontiers in Antibiotics, Vol 2 (2023)
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide. The development of novel
Externí odkaz:
https://doaj.org/article/b19c3d06f60449e4b8617a588c56b3ec
Autor:
John M. Ward, Thomas Pesnot, Helen C. Hailes, Benjamin R. Lichman, Eleanor D. Lamming, J. M. Smith
Publikováno v:
Green Chemistry. 17:852-855
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09802e0808af60b810ba5810cba74e9f
https://doi.org/10.1039/c4gc02325k
https://doi.org/10.1039/c4gc02325k
Autor:
Benjamin R, Lichman, Markus C, Gershater, Eleanor D, Lamming, Thomas, Pesnot, Altin, Sula, Nicholas H, Keep, Helen C, Hailes, John M, Ward
Publikováno v:
The Febs Journal
Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet–Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::19cea6311a539e91280a7107a07a41bb
https://pubmed.ncbi.nlm.nih.gov/25620686
https://pubmed.ncbi.nlm.nih.gov/25620686
Autor:
Juan D, Guzman, Thomas, Pesnot, Diana A, Barrera, Heledd M, Davies, Eleanor, McMahon, Dimitrios, Evangelopoulos, Parisa N, Mortazavi, Tulika, Munshi, Arundhati, Maitra, Eleanor D, Lamming, Richard, Angell, Markus C, Gershater, Joanna M, Redmond, Deborah, Needham, John M, Ward, Luis E, Cuca, Helen C, Hailes, Sanjib, Bhakta
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives (S)-Leucoxine, isolated from the Colombian Lauraceae tree Rhodostemonodaphne crenaticupula Madriñan, was found to inhibit the growth of Mycobacterium tuberculosis H37Rv. A biomimetic approach for the chemical synthesis of a wide array of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd75de37533da277f55bfab44e8a25c1
https://pubmed.ncbi.nlm.nih.gov/25656411
https://pubmed.ncbi.nlm.nih.gov/25656411