Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eleanor C. Row"'
Publikováno v:
Synthesis. 44:1964-1973
The [4+2] cycloaddition of 2-pyrones with substituted alkynylboronates has been studied. In general, the highest yielding cycloadditions were obtained in reactions that employed a trimethylsilyl-substituted alkynylboronate. The highest regioselectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a03dd9f9de151c2dfe800003ce36bd
https://doi.org/10.1055/s-0031-1291142
https://doi.org/10.1055/s-0031-1291142
Autor:
Andrew V. Stachulski, Chandrakala Pidathala, Eleanor C. Row, Raman Sharma, Neil G. Berry, Alexandre S. Lawrenson, Shelley L. Moores, Mazhar Iqbal, Joanne Bentley, Sarah A. Allman, Geoffrey Edwards, Alison Helm, Jennifer Hellier, Brent E. Korba, J. Edward Semple, Jean-Francois Rossignol
Publikováno v:
Journal of Medicinal Chemistry. 54:8670-8680
We report the activities of a number of thiazolides [2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure-activity relationships (SARs) of thiazolides against HCV are less pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7adafc290ce1606bb219bfefb622630
https://doi.org/10.1021/jm201264t
https://doi.org/10.1021/jm201264t
Autor:
Jennifer Hellier, Neil G. Berry, Chandrakala Pidathala, Eleanor C. Row, Jean-Francois Rossignol, Raman Sharma, Mazhar Iqbal, Brent E. Korba, Andrew V. Stachulski, Alison Helm, Geoffrey Edwards, Sarah Allman, Joanne Bentley, J. Edward Semple
Publikováno v:
Journal of Medicinal Chemistry. 54:4119-4132
We report the activities of a number of thiazolides [2-hydroxyaroyl-N-(thiazol-2-yl)amides] against hepatitis C virus (HCV) genotypes IA and IB, using replicon assays. The structure–activity relationships (SARs) of thiazolides against HCV are less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7d5ecb54aba7ce8deb33266efd1430
https://doi.org/10.1021/jm200153p
https://doi.org/10.1021/jm200153p
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:1-32
A variety of methods for the preparation of selectively mono-, di- or tri-labelled arenes are reviewed. The review concentrates on those for which the application to labelled synthesis has been demonstrated. Further methods, the application of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10b251af0ba86865761eb43ff2cdca17
https://doi.org/10.1002/jlcr.1783
https://doi.org/10.1002/jlcr.1783
Autor:
Neil G. Berry, Shelley L. Moores, Eleanor C. Row, Andrew V. Stachulski, I.S. Adagu, A. C. Lilian Low, David C. Warhurst, Jean-Francois Rossignol
Publikováno v:
Journal of Medicinal Chemistry. 49:1450-1454
We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d4185b9d6e9306d8b2a8121bae1d00
https://doi.org/10.1021/jm050973f
https://doi.org/10.1021/jm050973f
Publikováno v:
Drug Metabolism and Disposition. 34:324-330
Grapefruit juice has been found to cause an increase in the oral bioavailability of many therapeutic agents. Such interactions are believed to result from the mechanism-based inhibition of CYP3A4 activity in the intestine. Furanocoumarin dimers prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a502bbf709076217b058a4d3c26d456
https://doi.org/10.1124/dmd.105.007294
https://doi.org/10.1124/dmd.105.007294
Publikováno v:
ChemInform. 42
A variety of methods for the preparation of selectively mono-, di- or tri-labelled arenes are reviewed. The review concentrates on those for which the application to labelled synthesis has been demonstrated. Further methods, the application of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845673cfa51d34b0bc6f68c7012481a4
https://doi.org/10.1002/chin.201130238
https://doi.org/10.1002/chin.201130238
ChemInform Abstract: An Alkynylboronate Cycloaddition Strategy to Functionalized Benzyne Derivatives
Publikováno v:
ChemInform. 41
The cycloaddition of 2-pyrones with alkynylboronate (II) followed by C-B bond oxidation and a subsequent triflation gives rise to mixtures of regioisomers (VI) and (VII), which are shown to be useful benzyne precursors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df0f1a3b0e7ea66d76fecdecf8e8380
https://doi.org/10.1002/chin.201047030
https://doi.org/10.1002/chin.201047030
Autor:
Joseph P. A. Harrity, Eleanor C. Row, Patrick M. Delaney, George J. Ellames, James D. Kirkham
Publikováno v:
Chemical communications (Cambridge, England). 46(28)
A new approach to benzyne precursors has been developed that involves the [4+2] cycloaddition of trimethylsilyl alkynylboronates with 2-pyrones, followed by oxidation and trifluoromethylsulfonylation of the boronate moiety.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecffd2ee16f1f5774afce0f0635c3d6
https://pubmed.ncbi.nlm.nih.gov/20552132
https://pubmed.ncbi.nlm.nih.gov/20552132
Publikováno v:
Organic & Biomolecular Chemistry. 4:1604
A number of furanocoumarins isolated from grapefruit juice have been found to inhibit CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of analogues based on bergamottin to investigate the relationship between chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0f6617ca09487af4a022d50d08b305
https://doi.org/10.1039/b601096b
https://doi.org/10.1039/b601096b