Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eleanor C. Ory"'
Autor:
Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-21 (2022)
Abstract Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor
Externí odkaz:
https://doaj.org/article/16b3a6a66cbd4783a10d41a52c7ae93f
Autor:
Megan B. Stemberger, Julia A. Ju, Keyata N. Thompson, Trevor J. Mathias, Alexandra E. Jerrett, Katarina T. Chang, Eleanor C. Ory, David A. Annis, Makenzy L. Mull, Darin E. Gilchrist, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Cells, Vol 12, Iss 9, p 1266 (2023)
Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated in the mechanism of action of many anticancer therapies. Several lines of evidence suggest h
Externí odkaz:
https://doaj.org/article/fff120d70ebf46c392e1750ff30f723f
Autor:
Katarina T. Chang, Keyata N. Thompson, Stephen J. P. Pratt, Julia A. Ju, Rachel M. Lee, Trevor J. Mathias, Makenzy L. Mull, David A. Annis, Eleanor C. Ory, Megan B. Stemberger, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Cancers, Vol 15, Iss 3, p 884 (2023)
Cytoskeletal remodeling in circulating tumor cells (CTCs) facilitates metastatic spread. Previous oncology studies examine sustained aberrant calcium (Ca2+) signaling and cytoskeletal remodeling scrutinizing long-term phenotypes such as tumorigenesis
Externí odkaz:
https://doaj.org/article/246052652eec4a51a1c2f6d1aae3e91e
Autor:
Trevor J. Mathias, Julia A. Ju, Rachel M. Lee, Keyata N. Thompson, Makenzy L. Mull, David A. Annis, Katarina T. Chang, Eleanor C. Ory, Megan B. Stemberger, Takashi Hotta, Ryoma Ohi, Michele I. Vitolo, Marie-Jo Moutin, Stuart S. Martin
Publikováno v:
Cancers, Vol 14, Iss 7, p 1707 (2022)
Post-translational modifications (PTMs) of the microtubule network impart differential functions across normal cell types and their cancerous counterparts. The removal of the C-terminal tyrosine of α-tubulin (deTyr-Tub) as performed by the tubulin c
Externí odkaz:
https://doaj.org/article/a9e03d3afcd844afa649f9b0461c12df
Autor:
Stephen J. Pratt, Eleanor C Ory, Erick O. Hernández-Ochoa, Joseph P. Stains, Martin F. Schneider, Patrick C. Bailey, Julia A. Ju, Keyata Thompson, Christopher W. Ward, Trevor J. Mathias, Katarina T. Chang, David A Annis, Michele Vitolo, Rachel M. Lee, Stuart S. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance In breast cancer, the chronically stiffening mechanical microenvironment promotes tumor growth/invasion. However, the molecular details and integration of cancer mechanotransduction signaling pathways are not well understood. We find tha
Autor:
Trevor J. Mathias, Julia A. Ju, Christopher M. Jewell, Rachel M. Lee, Stephen J.P. Pratt, Keyata Thompson, Michele Vitolo, Eleanor C Ory, Cornell J. Lee, Stuart S. Martin
Publikováno v:
Lab Chip
The technical challenges of imaging non-adherent tumor cells pose a critical barrier to understanding tumor cell responses to the non-adherent microenvironments of metastasis, like the bloodstream or lymphatics. In this study, we optimized a microflu
Autor:
Christopher M. Jewell, Kristi R. Chakrabarti, Rachel M. Lee, Cornell J. Lee, Trevor J. Mathias, Olga Goloubeva, Stephen Pratt, Stuart S. Martin, Michele Vitolo, Julia A. Ju, Patrick C. Bailey, Keyata Thompson, Eleanor C Ory
Background: Clinical breast cancer imaging inevitably focuses on tumor growth rather than the metastatic dissemination that is a greater challenge for patient survival. Emerging preclinical evidence indicates that chemotherapy can elevate levels of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173bb163aba36befe813b0cf3fd8687d
https://doi.org/10.21203/rs.3.rs-127507/v1
https://doi.org/10.21203/rs.3.rs-127507/v1
Autor:
Keyata Thompson, Cornell J. Lee, Patrick C. Bailey, Christopher M. Jewell, Stephen J.P. Pratt, Stuart S. Martin, Eleanor C Ory, Katarina T. Chang, Karen F. Underwood, Julia A. Ju, Trevor M. Mathias, Lekhana Bhandary, Michele Vitolo, Rebecca A. Whipple
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating conditions. However, the traditional mammosphere assay inevitably introduces cell aggregatio
Autor:
Rachel M. Lee, Patrick C. Bailey, Keyata Thompson, Kristi R. Chakrabarti, Michele Vitolo, Eleanor C Ory, Cornell J. Lee, Stuart S. Martin, Stephen J.P. Pratt
Publikováno v:
iScience, Vol 8, Iss, Pp 29-39 (2018)
iScience
iScience
Summary The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by the field. Cell seeding densities of 1,000 to 100,000 cells/mL have been reported.
Autor:
Ashley A. Johnson, Trevor J. Mathias, Patrick C. Bailey, Stuart S. Martin, Keyata Thompson, Christopher W. Ward, Eleanor C Ory, James S. Lyons, Martin F. Schneider, Stephen J.P. Pratt, Matt Trudeau, Cornell J. Lee, Rachel M. Lee, Erick O. Hernández-Ochoa, Joseph P. Stains, Humberto C. Joca, Michele Vitolo
Publikováno v:
Oncotarget
Aggressive cellular phenotypes such as uncontrolled proliferation and increased migration capacity engender cellular transformation, malignancy and metastasis. While genetic mutations are undisputed drivers of cancer initiation and progression, it is