Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eleanor C, Wilde"'
Autor:
James A. Tonkin, Ume-Kulsoom Shah, Shareen H. Doak, M. R. Brown, Katherine E. Chapman, George E. Johnson, Eleanor C. Wilde, Gareth J.S. Jenkins, Jatin R Verma
Publikováno v:
Mutagenesis. 35:445-452
In vitro genotoxicity studies are a quick and high throughput approach to assess the genotoxic potential of chemicals; however, the reliability of these tests and their relevance to in vivo effects depends on the choice of representative cell line an
Autor:
Ann T. Doherty, George E. Johnson, Fiona M. Chapman, Katherine E. Chapman, Jatin R. Verma, Eleanor C. Wilde, James A. Tonkin, Leanne M. Stannard, Gareth J.S. Jenkins, M. Rowan Brown, Ume-Kulsoom Shah, Anna L. Seager, Shareen H. Doak
Publikováno v:
Archives of Toxicology
Current in vitro genotoxicity tests can produce misleading positive results, indicating an inability to effectively predict a compound’s subsequent carcinogenic potential in vivo. Such oversensitivity can incur unnecessary in vivo tests to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a23b0c49eed7468aa74bcdecf69813
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
https://cronfa.swan.ac.uk/Record/cronfa55186/Download/55186__18359__b5f156f08e5d4ed9bbdcc8a37f5027bb.pdf
Autor:
George E. Johnson, Katherine E. Chapman, Katja Brüsehafer, Gareth J.S. Jenkins, M. Rowan Brown, Jatin R. Verma, Ume-Kulsoom Shah, Leanne M. Stannard, Eleanor C. Wilde, Shareen H. Doak, Anna L. Seager, James A. Tonkin, Ann T. Doherty
Publikováno v:
Archives of Toxicology
Human exposure to carcinogens occurs via a plethora of environmental sources, with 70–90% of cancers caused by extrinsic factors. Aberrant phenotypes induced by such carcinogenic agents may provide universal biomarkers for cancer causation. Both cu
Autor:
Jatin R, Verma, Benjamin J, Rees, Eleanor C, Wilde, Catherine A, Thornton, Gareth J S, Jenkins, Shareen H, Doak, George E, Johnson
Publikováno v:
Archives of Toxicology
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster
Autor:
William C. Gunther, Ann Schuermans, John Nicolette, Fabrice Nesslany, Ronald D. Fiedler, Stephen D. Dertinger, Céline Defrain, Laura Custer, Thomas J. Shutsky, Catherine J. Thiffeault, Robert H. Heflich, Paul Sonders, Amanda Giddings, Ljubica Krsmanovic, Javed A. Bhalli, Eleanor C. Wilde, Anthony M. Lynch, James T. MacGregor, Kevin Sweder, Osamu Tajima, Takafumi Kimoto, Andrew Henwood, Jing Shi, Terry Van Doninck, Souk Phonethepswath, Carol Gleason, Bas-jan M. van der Leede, Hans-Werner Vohr, Daniel J. Roberts, Pamela Weller, Azeddine Elhajouji, Yoshie Hiwata, Leon F. Stankowski, Joel Murray, Julia Kenny, Kentaro Tanaka
Publikováno v:
Environmental and Molecular Mutagenesis. 52:690-698
A collaborative international trial was conducted to evaluate the reproducibility and transferability of an in vivo mutation assay based on the enumeration of CD59-negative rat erythrocytes, a phenotype that is indicative of Pig-a gene mutation. Four
Autor:
Gareth J.S. Jenkins, Catherine A. Thornton, George E. Johnson, Shareen H. Doak, Eleanor C. Wilde, Benjamin J. Rees, Jatin R. Verma
Publikováno v:
Archives of Toxicology.
The use of manual microscopy for the scoring of chromosome damage in the in vitro micronucleus assay is often associated with user subjectivity. This level of subjectivity can be reduced by using automated platforms, which have added value of faster