Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Eleanor A.L. Bagg"'
1
Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6
Autor: Celia J. Webby, Michael A. McDonough, Eleanor A.L. Bagg, T. Krojer, Kathryn L. Kavanagh, Danica Butler, Christopher J. Schofield, Monica Mantri, Grazyna Kochan, Udo Oppermann
Lysyl and prolyl hydroxylations are well-known post-translational modifications to animal and plant proteins with extracellular roles. More recent work has indicated that the hydroxylation of intracellular animal proteins may be common. JMJD6 catalys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f144cb15e40f628abb21964256b143
https://doi.org/10.1016/j.jmb.2010.05.054
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2
The potential of 2-oxoglutarate oxygenases acting on nucleic acids as therapeutic targets
Autor: Christopher J. Schofield, Eleanor A.L. Bagg, Armin Thalhammer, Wei Shen Aik
Human 2-oxoglutarate dependent oxygenases, including histone demethylases and hypoxia inducible transcription factor hydroxylases, catalyze posttranslational modifications and are being pursued as targets for cancer, anemia and ischemic and inflammat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d058fd033077d4497c3a32a2fbc6a6
https://ora.ox.ac.uk/objects/uuid:63abf861-b82d-499c-8211-8c26b037c234
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3
Specificity of localization and phosphotransfer in the CheA proteins ofRhodobacter sphaeroides
Autor: Jennifer Hill, Judith P. Armitage, Rebecca Hamer, David A. Wilkinson, Kathryn A. Scott, Steven L. Porter, Eleanor A.L. Bagg
Publikováno v: Molecular Microbiology. 76:318-330
Specificity of protein-protein interactions plays a vital role in signal transduction. The chemosensory pathway of Rhodobacter sphaeroides comprises multiple homologues of chemotaxis proteins characterized in organisms such as Escherichia coli. Three
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec95573b7a1ff0d0176723b90232062
https://doi.org/10.1111/j.1365-2958.2010.07095.x
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4
Emulsion PCR significantly improves nonequilibrium capillary electrophoresis of equilibrium mixtures-based aptamer selection: allowing for efficient and rapid selection of aptamer to unmodified ABH2 protein
Autor: Christine Bruce, Svetlana M. Krylova, Eleanor A.L. Bagg, Roman Yufa, Christopher J. Schofield, Sergey N. Krylov
Publikováno v: Analytical chemistry. 87(2)
Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM), a homogeneous approach to select DNA aptamers, is among the most efficient partitioning techniques. In contrast with surface-based systematic evolution of ligands by exponenti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d143939004aefcc9a5ed07c777842b
https://pubmed.ncbi.nlm.nih.gov/25495441
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6
Structural basis for inhibition of the fat mass and obesity associated protein (FTO)
Autor: Kar Kheng Yeoh, Clarisse Lejeune, Zhihong Zhang, Marina Demetriades, Eleanor A.L. Bagg, Muhammad K. K. Hamdan, Wei Shen Aik, Michael A. McDonough, Christopher J. Schofield
Publikováno v: Journal of medicinal chemistry. 56(9)
The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic acid demethylase that acts on substrates including 3-methylthymidine, 3-methyluracil, and 6-m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c6fed989bb01d8d7704ed91ae9ec54
http://ora.ox.ac.uk/objects/uuid:657ecdd8-ef77-476f-8138-776f9f9e2beb
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7
Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases
Autor: Eleanor A.L. Bagg, Vasilij Koshkin, Sergey N. Krylov, Svetlana M. Krylova, Christopher J. Schofield
Publikováno v: Journal of medicinal chemistry. 55(7)
The Escherichia coli (E. coli) AlkB protein and its functional human homologues belong to a subfamily of 2-oxoglutarate (2OG) dependent oxygenases (2OG oxygenases for simplicity) that enable the repair of cytotoxic methylation damage in nucleic acids
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae42a63e9237e42312350845a7c0917
http://ora.ox.ac.uk/objects/uuid:871abafd-2f6f-435b-aac0-23c066a66665
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8
Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase
Autor: David W. Wegman, Michael A. McDonough, Dack Kevin Neil, Marina Demetriades, Sergey N. Krylov, Louise J. Walport, Eleanor A.L. Bagg, Mun Chiang Chan, Jerome Ma, Svetlana M. Krylova, Wei Shen Aik, Esther C. Y. Woon, Christopher J. Schofield
Publikováno v: Journal of Medicinal Chemistry
2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of these enzymes are linked to physiology, their regulatory roles are unclear. Hence, there is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adeca90e5f3d124b0c9b8d8b0fd2b41
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9
DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes
Autor: Anna A. Karkhanina, Michael U. Musheev, Eleanor A.L. Bagg, Sergey N. Krylov, Christopher J. Schofield, Svetlana M. Krylova
Publikováno v: Analytical Biochemistry.
The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating en
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http://ora.ox.ac.uk/objects/uuid:c5732123-c4a1-4846-951f-63c6dee7d504
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