Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Eleanor A. Woodward"'
Autor:
Agustin Sgro, Joseph Cursons, Charlene Waryah, Eleanor A. Woodward, Momeneh Foroutan, Ruqian Lyu, George C. T. Yeoh, Peter J. Leedman, Pilar Blancafort
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plastic
Externí odkaz:
https://doaj.org/article/57f17a1387644e289dd4a0fa2cd044ff
Autor:
Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 Domain Containing gene (AAMDC) is frequently amplified in the IntClus2 subgroup of ER + breast cancer. Here, the authors show that AAMDC drives tumourigenesis through activating PI3K-AKT-mTOR pathway for metabolic repro
Externí odkaz:
https://doaj.org/article/7a78efc95f94434186efe33c5a90c19a
Autor:
Eleanor L. Woodward, Minjun Yang, Larissa H. Moura-Castro, Hilda van den Bos, Rebeqa Gunnarsson, Linda Olsson-Arvidsson, Diana C. J. Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson
Publikováno v:
Nature Communications. 14
High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b769ab505886ed414047553871c26f89
https://doi.org/10.1038/s41467-023-37356-5
https://doi.org/10.1038/s41467-023-37356-5
Autor:
Rozbeh Jafari, Anders Castor, Henrik Lilljebjörn, Duncan T. Odom, Mattias Vesterlund, Linda Olsson, Minjun Yang, Kajsa Paulsson, Naveen Ravi, Ioannis Siavelis, Eleanor L. Woodward, Janne Lehtiö, Louise Harewood, Larissa H. Moura-Castro, Thoas Fioretos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Nature Communications
Yang, M, Vesterlund, M, Siavelis, I, Moura-Castro, LH, Castor, A, Fioretos, T, Jafari, R, Lilljebjörn, H, Odom, DT, Olsson, L, Ravi, N, Woodward, EL, Harewood, L & Paulsson, K 2019, ' Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia. ', Nature Communications, vol. 10, 1519 . https://doi.org/10.1038/s41467-019-09469-3
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16600b044471be8bd09c1c78c5151683
https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
https://doaj.org/article/8fb5db51725140f997f862673ee0cf51
Autor:
Kevin D. G. Pfleger, Wan Jun Tie, Joseph Cursons, Bum-Kyu Lee, Piotr Kozlowski, Edina Wang, Rabab Rashwan, Ciara Duffy, Mohit Jain, Magdalena Ratajska, Wojciech Biernat, Pilar Blancafort, Piotr Czapiewski, Anabel Sorolla, Agustin Sgro, Andrew J. Woo, Christina Curtis, Jeremy Parry, Kim A. Lagerborg, Charlene Babra Waryah, Elizabeth K. M. Johnstone, Jonghwan Kim, Bartosz Wasag, Eleanor A. Woodward, Javier A. Menendez, Nathan J. Pavlos, Emily Golden, Andrew Redfern, Iwona Kardaś, Heng B. See, Elisabet Cuyàs, Adam Gorczyński
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Adipogenesis associated Mth938 domain containing (AAMDC) represents an uncharacterized oncogene amplified in aggressive estrogen receptor-positive breast cancers. We uncover that AAMDC regulates the expression of several metabolic enzymes involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3e71d869a3edf1298d93e42ec3af6c
https://pubmed.ncbi.nlm.nih.gov/33772001
https://pubmed.ncbi.nlm.nih.gov/33772001
Autor:
Diwei Ho, Kevin D. G. Pfleger, Kathleen Davern, Pilar Blancafort, Emily Golden, K. Swaminathan Iyer, Anabel Sorolla, Ciara Duffy, Elizabeth K. M. Johnstone, Andrew Redfern, Boris Baer, Edina Wang, Eleanor A. Woodward
Publikováno v:
NPJ precision oncology, vol 4, iss 1
npj Precision Oncology, Vol 4, Iss 1, Pp 1-16 (2020)
NPJ Precision Oncology
npj Precision Oncology, Vol 4, Iss 1, Pp 1-16 (2020)
NPJ Precision Oncology
Despite decades of study, the molecular mechanisms and selectivity of the biomolecular components of honeybee (Apis mellifera) venom as anticancer agents remain largely unknown. Here, we demonstrate that honeybee venom and its major component melitti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac171e0c206e5e75287752f523a7c9d0
https://escholarship.org/uc/item/5x54k7vj
https://escholarship.org/uc/item/5x54k7vj
Autor:
Henrik Lilljebjörn, Rebeqa Gunnarsson, Andrea Biloglav, Thoas Fioretos, Eleanor L. Woodward, Linda Olsson, Minjun Yang, Bertil Johansson, Kajsa Paulsson
Publikováno v:
Blood. 138:4315-4315
Introduction. Pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common pediatric hematological malignancy and it remains an important cause of morbidity and mortality in children. In this study, we performed an allele-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caa33c9fd74f68703557f2c7021ebc81
https://doi.org/10.1182/blood-2021-144808
https://doi.org/10.1182/blood-2021-144808
Autor:
Kajsa Paulsson, Larissa H. Moura-Castro, Minjun Yang, Floris Foijer, Hilda van den Bos, Eleanor L. Woodward, Diana C.J. Spierings
Publikováno v:
Blood. 138:3489-3489
High hyperdiploid (HeH) B-cell precursor acute lymphoblastic leukemia (BCP ALL) is characterized by a very specific nonrandom gain of chromosomes; a feature distinct from other types of aneuploid tumor types that usually display very heterogeneous ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfcb19ff5b5402dfff02f6eb7e80a3ce
https://doi.org/10.1182/blood-2021-145521
https://doi.org/10.1182/blood-2021-145521
Publikováno v:
Veterinary Anaesthesia and Analgesia. 44:1382-1390
Objective To evaluate the maternal and foetal uptake of transdermal fentanyl patch applied to the groin of pregnant sheep following surgery. Study design Prospective series. Animals A group of 16 singleton pregnant sheep underwent anaesthesia for lap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ccb1b9776d816e861aca563bab2fe7
https://doi.org/10.1016/j.vaa.2017.05.001
https://doi.org/10.1016/j.vaa.2017.05.001
Autor:
Sarah J. Stock, Ryuta Kitanishi, John P. Newnham, Tadashi Matsuda, Haruo Usuda, Gabrielle C. Musk, Masatoshi Saito, Eleanor A. Woodward, Yuichiro Miura, Shinichi Sato, Shimpei Watanabe, Matthew W. Kemp, Suhas G. Kallapur
Publikováno v:
Artificial Organs. 41:959-968
Ex vivo uterine environment (EVE) therapy is an experimental neonatal intensive care strategy wherein gas exchange is performed by membranous oxygenators attached to the umbilical vessels. Our aim was to assess the ability of a newly refined EVE syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d07e3d6100061242a7ccb2d31f3970a9
https://doi.org/10.1111/aor.12974
https://doi.org/10.1111/aor.12974