Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Eleanor, Gregson"'
Autor:
Eleanor Gregson, Sarah Killcoyne, Rebecca C. Fitzgerald, Dan J. Woodcock, Sujath Abbas, Rachel de la Rue, Moritz Gerstung, Adrienn Blasko, Aikaterini Varanou Jenkins, David C. Wedge, Cassandra Kosmidou, Matthew D. Eldridge, Ahmad Miremadi, Wladyslaw Januszewicz
Publikováno v:
Killcoyne, S, Gregson, E, Wedge, D C, Woodcock, D J, Eldridge, M D, Rue, R D L, Miremadi, A, Abbas, S, Blasko, A, Kosmidou, C, Januszewicz, W, Jenkins, A V, Gerstung, M & Fitzgerald, R C 2020, ' Genomic copy number predicts esophageal cancer years before transformation ', Nature Medicine, vol. 26, no. 11, pp. 1726-1732 . https://doi.org/10.1038/s41591-020-1033-y, https://doi.org/10.1038/s41591-020-1033-y
Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis by many years1–4. We assess whether these genomic signals can be used for early detection and pre-emptive cancer treatment using the neoplastic precursor lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583cb2581ee6e55f52312425ba520c4d
https://www.repository.cam.ac.uk/handle/1810/307065
https://www.repository.cam.ac.uk/handle/1810/307065
Autor:
Sarah, Killcoyne, Eleanor, Gregson, David C, Wedge, Dan J, Woodcock, Matthew D, Eldridge, Rachel, de la Rue, Ahmad, Miremadi, Sujath, Abbas, Adrienn, Blasko, Cassandra, Kosmidou, Wladyslaw, Januszewicz, Aikaterini Varanou, Jenkins, Moritz, Gerstung, Rebecca C, Fitzgerald
Publikováno v:
Nature medicine. 26(11)
Recent studies show that aneuploidy and driver gene mutations precede cancer diagnosis by many years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::334c4d6b859e6005024c58d6ea47bd76
https://pubmed.ncbi.nlm.nih.gov/32943767
https://pubmed.ncbi.nlm.nih.gov/32943767
Autor:
Dan J. Woodcock, Rachel de la Rue, Wladyslaw Januszewicz, Eleanor Gregson, David C. Wedge, Matthew D. Eldridge, Moritz Gerstung, Sujath Abbas, Adrienn Blasko, Ahmad Miremadi, Sarah Killcoyne, Rebecca C. Fitzgerald, Aikaterini Varanou Jenkins
Publikováno v:
Killcoyne, S, Gregson, E, Wedge, D C, Woodcock, D J, Eldridge, M, Rue, R D L, Miremadi, A, Abbas, S, Blasko, A, Januszewicz, W, Jenkins, A V, Gerstung, M & Fitzgerald, R C 2020, ' Genomic copy number predicts oesophageal cancer years before transformation ', bioRxiv . https://doi.org/10.1101/2020.02.27.967612
SummaryCancer arises through a process of somatic evolution and recent studies have shown that aneuploidies and driver gene mutations precede cancer diagnosis by several years to decades1–4 Here, we address the question whether such genomic signals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5c261280462c7f018fe66effae0b76
Autor:
S A Rahman, R C Walker, M A Lloyd, B L Grace, G I van Boxel, B F Kingma, J P Ruurda, R van Hillegersberg, S Harris, S Parsons, S Mercer, E A Griffiths, J R O'Neill, R Turkington, R C Fitzgerald, T J Underwood, Ayesha Noorani, Rachael Fels Elliott, Paul A W Edwards, Nicola Grehan, Barbara Nutzinger, Jason Crawte, Hamza Chettouh, Gianmarco Contino, Xiaodun Li, Eleanor Gregson, Sebastian Zeki, Rachel de la Rue, Shalini Malhotra, Simon Tavaré, Andy G Lynch, Mike L Smith, Jim Davies, Charles Crichton, Nick Carroll, Peter Safranek, Andrew Hindmarsh, Vijayendran Sujendran, Stephen J Hayes, Yeng Ang, Shaun R Preston, Sarah Oakes, Izhar Bagwan, Vicki Save, Richard J E Skipworth, Ted R Hupp, J Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Timothy J Underwood, Fergus Noble, James P Byrne, Jamie J Kelly, Jack Owsley, Hugh Barr, Neil Shepherd, Oliver Old, Jesper Lagergren, James Gossage, Andrew Davies Fuju Chang, Janine Zylstra, Vicky Goh, Francesca D Ciccarelli, Grant Sanders, Richard Berrisford, Catherine Harden, David Bunting, Mike Lewis, Ed Cheong, Bhaskar Kumar, Simon L Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Victor Eneh, Laszlo Igali, Michael Scott, Shamila Sothi, Sari Suortamo, Suzy Lishman, George B Hanna, Christopher J Peters, Anna Grabowska
Publikováno v:
on behalf of the OCCAMS Consortium, Rahman, S A, Walker, R C, Lloyd, M A, Grace, B L, van Boxel, G I, Kingma, B F, Ruurda, J P, van Hillegersberg, R, Harris, S, Parsons, S, Mercer, S, Griffiths, E A, O'Neill, J R, Turkington, R, Fitzgerald, R C & Underwood, T J 2020, ' Machine learning to predict early recurrence after oesophageal cancer surgery ', British Journal of Surgery, vol. 107, no. 8, pp. 1042-1052 . https://doi.org/10.1002/bjs.11461
The British Journal of Surgery
The British Journal of Surgery
Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20–30 per cent despite the widespread use of neoadjuvant treatment. Quantification of this risk is difficult and existing models perform poorly. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baa9c5e8d31ed77fb83c07c2aab1614
Publikováno v:
British Journal of Cancer
Barrett's oesophagus (BE) is the premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Diagnostically, p53 immunohistochemistry remains the only biomarker recommended clinically to aid histopathological diagnosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5cbfb70aa6c4f6b0c1622a91fb9f66
http://europepmc.org/articles/PMC4985359
http://europepmc.org/articles/PMC4985359
Autor:
David C. Wedge, Eleanor Gregson, Matthew D. Eldridge, Katerina Jenkins, Lawrence Bower, Ahmad Miremadi, Rachel de la Rue, Sarah Killcoyne, Rebecca C. Fitzgerald
Publikováno v:
Gastroenterology. 152:S106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f27d137abff5644091121a32f02a2f
https://doi.org/10.1016/s0016-5085(17)30694-7
https://doi.org/10.1016/s0016-5085(17)30694-7