Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eldridge N, Nartey"'
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Autor:
Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
Publikováno v:
Journal of medicinal chemistry. 64(21)
Elevated expression of the
Autor:
Liping Wang, Shihyun You, Ninad V. Prabhu, Hongfeng Deng, Danielle G. Smith, Jing Chai, Ginger H Tomberlin, Robert T. Nolte, James H. Nichols, G. Bruce Wisely, Edgar R. Wood, Cecil E Rise, Hamilton D. Dickson, J. David Taylor, Luz Helena Kryn, Randy K. Bledsoe, Timothy P. Sheahan, Yun Ding, Sarah Harris-Gurley, Eldridge N. Nartey, J. Brad Shotwell, Bing Xia, Philias Daka, Vince Tai
Publikováno v:
Journal of Biological Chemistry
2',5'-Oligoadenylate synthetase (OAS) enzymes and RNase-L constitute a major effector arm of interferon (IFN)-mediated antiviral defense. OAS produces a unique oligonucleotide second messenger, 2',5'-oligoadenylate (2-5A), that binds and activates RN
Autor:
Daniel F. Hassler, Robert T. Nolte, Denis Patrick, Jun Tang, Masato Nakano, Kazunori Ozawa, Maureen L. Ho, Eldridge N. Nartey, Yasushi Miyazaki, Yutaka Maeda, Hideyuki Sato, Anne T. Truesdale, Masaki Sugai, Liping Wang, Yuji Okamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1773-1778
During our effort to develop dual VEGFR2 and Tie-2 inhibitors as anti-angiogenic agents for cancer therapy, we discovered 4-amino-5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)- aminocarbonylamino)phenyl)furo[2,3-d]pyrimidine (8a) possessing strong inhib
Autor:
Anne T. Truesdale, Masato Nakano, Kendra E. Hightower, Yasushi Miyazaki, Eldridge N. Nartey, J. Darren Stuart, Laurie S. Kane-Carson, Hideyuki Sato
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:250-254
A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and
Autor:
Anne T. Truesdale, Liping Wang, Jeffrey A. Stafford, James Marvin Veal, Robert T. Nolte, Victoria B. Knick, Sharon K. Rudolph, Mui Cheung, Kristen Elizabeth Nailor, Eldridge N. Nartey, Douglas M. Sammond, Rakesh Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3519-3523
A series of dianilinopyrimidineureas demonstrate potency as VEGFR2 kinase inhibitors.
Autor:
Kelly Anderson, Zhihong Lai, Octerloney B. Mcdonald, J. Darren Stuart, Eldridge N. Nartey, Mary Ann Hardwicke, Ken Newlander, Dashyant Dhanak, Jerry Adams, Denis Patrick, Robert A. Copeland, Peter J. Tummino, Jingsong Yang
Publikováno v:
Biochemical Journal; May2009, Vol. 420 Issue 2, p259-265, 7p