Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Eldo KUZHIKANDATHIL"'
1
Bioisosteric Heterocyclic Versions of 7-{[2-(4-Phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of Highly Potent and Selective Agonists for Dopamine D3 Receptor with Potent in Vivo Activity
Autor: Eldo Kuzhikandathil, Balaram Ghosh, Stuart Hazeldine, Aloke K. Dutta, Swati Biswas, Maarten E. A. Reith, Ingrid Parrington
Publikováno v: Journal of Medicinal Chemistry. 51:3005-3019
In the current report, we extend the SAR study on our hybrid structure 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol further to include heterocyclic bioisosteric analogues. Binding assays were carried out with HE
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ac05a908834d97e79cc1a8bcbf07f6
https://doi.org/10.1021/jm701524h
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2
Further Structure–Activity Relationships Study of Hybrid 7-{[2-(4-Phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol Analogues: Identification of a High-Affinity D3-Preferring Agonist with Potent in Vivo Activity with Long Duration of Action
Autor: Suhong Zhang, Maarten E. A. Reith, Swati Biswas, Eldo Kuzhikandathil, Aloke K. Dutta, Fernando Fernandez, Balaram Ghosh, Juan Zhen
Publikováno v: Journal of Medicinal Chemistry. 51:101-117
This paper describes an extended structure-activity relationships study of aminotetralin-piperazine-based hybrid molecules developed earlier for dopamine D2/D3 receptors. Various analogues as positional isomers have been developed where location of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3fc83b69ce0f3aafb8891d0061a2e8
https://doi.org/10.1021/jm070860r
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6
Akademický článek
Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ.
Autor: Del Rosario, John Smith, Yudin, Yevgen, Su, Songxue, Hartle, Cassandra M, Mirshahi, Tooraj, Rohacs, Tibor
Publikováno v: EMBO Reports; 5/6/2020, Vol. 21 Issue 5, p1-12, 12p
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7
Akademický článek
The HIV Antiretroviral Drug Efavirenz has LSD-Like Properties.
Autor: Gatch, Michael B, Kozlenkov, Alexey, Huang, Ren-Qi, Yang, Wenjuan, Nguyen, Jacques D, González-Maeso, Javier, Rice, Kenner C, France, Charles P, Dillon, Glenn H, Forster, Michael J, Schetz, John A
Publikováno v: Neuropsychopharmacology; Nov2013, Vol. 38 Issue 12, p2373-2384, 12p, 2 Charts, 4 Graphs
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9
Akademický článek
Stimulus-Evoked Modulation of Sensorimotor Pyramidal Neuron EPSPs.
Autor: KOHN, ADAM, METZ, CAROL, TOMMERDAHL, MARK A., WHITSEL, BARRY L.
Publikováno v: Journal of Neurophysiology; Dec2002, Vol. 88 Issue 6, p3331-3347, 17p
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