Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Autor: Lyons, Paul A, Peters, James E, Alberici, Federico, Liley, James, Coulson, Richard M R, Astle, William, Baldini, Chiara, Bonatti, Francesco, Cid, Maria C, Elding, Heather, Emmi, Giacomo, Epplen, Jörg, Guillevin, Loïc, Jayne, David R W, Jiang, Tao, Gunnarsson, Iva, Lamprecht, Peter, Leslie, Stephen, Little, Mark A, Martorana, Davide, Moosig, Frank, Neumann, Thomas, Ohlsson, Sophie, Quickert, Stefanie, Ramirez, Giuseppe A, Rewerska, Barbara, Schett, Georg, Sinico, Renato A, Szczeklik, Wojciech, Tesar, Vladimir, Vukcevic, Damjan, Terrier, Benjamin, Watts, Richard A, Vaglio, Augusto, Holle, Julia U, Wallace, Chris, Smith, Kenneth G C

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15b779b313900a32da0b1c6dad0a677f

Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Autor: Lyons, Paul A., Peters, James E., Alberici, Federico, Liley, James, Coulson, Richard M.R., Astle, William, Baldini, Chiara, Bonatti, Francesco, Cid, Maria C., Elding, Heather, Emmi, Giacomo, Epplen, Jorg, Guillevin, Loic, Jayne, David R.W., Jiang, Tao, Gunnarsson, Iva, Lamprecht, Peter, Leslie, Stephen, Little, Mark A., Martorana, Davide, Moosig, Frank, Neumann, Thomas, Ohlsson, Sophie, Quickert, Stefanie, Ramirez, Giuseppe, Rewerska, Barbara, Schett, George, Sinico, Renato A., Szczeklik, Wojciech, Tesar, Vladimir, Vukcevic, Damjan, The European Vasculitis Genetics Consortium, Terrier, Benjamin, Watts, Richard A., Vaglio, Augusto, Holle, Julia U., Wallace, Chris, Smith, Kenneth G.C.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::19b5c4899804f62f95a9b252757d7238
https://eprints.gla.ac.uk/199191/7/199191.pdf

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

Autor: Ecker, Simone, Chen, Lu, Pancaldi, Vera, Bagger, Frederik O., Fernández, José María, Carrillo de Santa Pau, Enrique, Juan, David, Mann, Alice L., Watt, Stephen, Casale, Francesco Paolo, Sidiropoulos, Nikos, Rapin, Nicolas Philippe Jean-Pierre, Merkel, Angelika, Stunnenberg, Hendrik G, Stegle, Oliver, Frontini, Mattia, Downes, Kate, Pastinen, Tomi, Kuijpers, Taco W, Rico, Daniel, Valencia, Alfonso, Beck, Stephan, Soranzo, Nicole, Paul, Dirk S., Albers, Cornelis A., Amstislavskiy, Vyacheslav, Ashford, Sofie, Bomba, Lorenzo, Bujold, David, Burden, Frances, Busche, Stephan, Caron, Maxime, Chen, Shu-Huang, Cheung, Warren A., Clarke, Laura, Colgiu, Irina, Datta, Avik, Delaneau, Oliver, Elding, Heather, Farrow, Samantha, Garrido-Martín, Diego, Ge, Bing, Guigo, Roderic, Iotchkova, Valentina, Kundu, Kousik, Kwan, Tony, Lambourne, John J., Lowy, Ernesto, Mead, Daniel, Pourfarzad, Farzin, Redensek, Adriana, Rehnstrom, Karola, Rendon, Augusto, Richardson, David M., Risch, Thomas, Rowlston, Sophia, Shao, Xiaojian, Simon, Marie Michelle, Sultan, Marc, Walter, Klaudia, Wilder, Steven P., Yan, Ying, Antonarakis, Stylianos E., Bourque, Guillaume, Dermitzakis, Emmanouil T., Flicek, Paul, Lehrach, Hans, Martens, Joost H A, Yaspo, Marie-Laure, Ouwehand, Willem H.

Publikováno v: Ecker, S, Chen, L, Pancaldi, V, Bagger, F O, Fernández, J M, Carrillo de Santa Pau, E, Juan, D, Mann, A L, Watt, S, Casale, F P, Sidiropoulos, N, Rapin, N P J-P, Merkel, A, Stunnenberg, H G, Stegle, O, Frontini, M, Downes, K, Pastinen, T, Kuijpers, T W, Rico, D, Valencia, A, Beck, S, Soranzo, N, Paul, D S, Albers, C A, Amstislavskiy, V, Ashford, S, Bomba, L, Bujold, D, Burden, F, Busche, S, Caron, M, Chen, S-H, Cheung, W A, Clarke, L, Colgiu, I, Datta, A, Delaneau, O, Elding, H, Farrow, S, Garrido-Martín, D, Ge, B, Guigo, R, Iotchkova, V, Kundu, K, Kwan, T, Lambourne, J J, Lowy, E, Mead, D, Pourfarzad, F, Redensek, A, Rehnstrom, K, Rendon, A, Richardson, D M, Risch, T, Rowlston, S, Shao, X, Simon, M M, Sultan, M, Walter, K, Wilder, S P, Yan, Y, Antonarakis, S E, Bourque, G, Dermitzakis, E T, Flicek, P, Lehrach, H, Martens, J H A, Yaspo, M-L & Ouwehand, W H 2017, ' Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types ', Genome Biology, vol. 18, no. 1, 18 . https://doi.org/10.1186/s13059-017-1156-8

Background: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results: We apply a novel analytical approach to measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::5e17eb2f9f30ac1f5d8217647f6c62d7
https://curis.ku.dk/ws/files/181453200/Ecker_2017_Genome_wide_analysis.pdf

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