Metabolic Age Based on the BBMRI-NL ¹ H-NMR Metabolomics Repository as Biomarker of Age-related Disease.

Autor: van den Akker EB; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Department of Biomedical Data Sciences, Leiden Computational Biology Center (E.B.v.d.A., M.J.T.R.), Leiden University Medical Center, the Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, the Netherlands (E.B.v.d.A., M.J.T.R.)., Trompet S; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Department of Internal Medicine, Division of Gerontology and Geriatrics (S.T., S.P.M.), Leiden University Medical Center, the Netherlands., Barkey Wolf JJH; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.)., Beekman M; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.)., Suchiman HED; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.)., Deelen J; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Max Planck Institute for Biology of Ageing, Cologne, Germany (J.D., P.E.S.)., Asselbergs FW; Department of Cardiology, Division of Heart and Lungs (F.W.A.), University Medical Center Utrecht, the Netherlands.; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht (F.W.A.).; Faculty of Population Health Sciences, Institute of Cardiovascular Science (F.W.A.), Institute of Health Informatics, UCL, London, United Kingdom.; Farr Institute of Health Informatics Research (F.W.A.), Institute of Health Informatics, UCL, London, United Kingdom., Boersma E; Thorax Center (E.B.), Erasmus Medical Center, Rotterdam, the Netherlands., Cats D; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.)., Elders PM; Department of General Practice and Elderly Care Medicine (P.M.E.), VU University Medical Center, the Netherlands.; Amsterdam Public Health Research Institute (P.M.E., B.W.J.H.P., L.M.'t.H., D.I.B.), VU University Medical Center, the Netherlands., Geleijnse JM; Division of Human Nutrition and Health, Wageningen University, the Netherlands (J.M.G.)., Ikram MA; Department of Epidemiology (M.A.I., C.M.v.D.), Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Radiology (M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Neurology (M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands., Kloppenburg M; Department of Rheumatology (M.K.), Leiden University Medical Center, the Netherlands.; Department of Clinical Epidemiology (M.K.), Leiden University Medical Center, the Netherlands., Mei H; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Department of Biomedical Data Sciences, Sequencing Analysis Support Core (H.M.), Leiden University Medical Center, the Netherlands., Meulenbelt I; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.)., Mooijaart SP; Department of Biomedical Data Sciences, Leiden Computational Biology Center (E.B.v.d.A., M.J.T.R.), Leiden University Medical Center, the Netherlands., Nelissen RGHH; Department of Orthopaedics (R.G.H.H.N.), Leiden University Medical Center, the Netherlands., Netea MG; Department for Genomics and Immunoregulation, Life and Medical Sciences Institute, University of Bonn, Germany (M.G.N.)., Penninx BWJH; Amsterdam Public Health Research Institute (P.M.E., B.W.J.H.P., L.M.'t.H., D.I.B.), VU University Medical Center, the Netherlands.; Department of Psychiatry (B.W.J.H.P.), VU University Medical Center, the Netherlands., Slofstra M; Department of Genetics, University of Groningen, the Netherlands (M.S., M.A.S., C.W., A.Z.)., Stehouwer CDA; Department of Internal Medicine, Maastricht University Medical Center, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.).; School for Cardiovascular Diseases (Cardiovascular Research Institute Maastricht [CARIM]), Maastricht University, Maastricht, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.)., Swertz MA; Department of Genetics, University of Groningen, the Netherlands (M.S., M.A.S., C.W., A.Z.)., Teunissen CE; Neurochemistry Laboratory, Clinical Chemistry Department (C.E.T.), Amsterdam University Medical Center, the Netherlands., Terwindt GM; Department of Neurology (G.M.T.), Leiden University Medical Center, the Netherlands., 't Hart LM; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Department of Cell and Chemical Biology (L.M.'t.H.), Leiden University Medical Center, the Netherlands.; Amsterdam Public Health Research Institute (P.M.E., B.W.J.H.P., L.M.'t.H., D.I.B.), VU University Medical Center, the Netherlands.; Department of Epidemiology and Biostatistics (L.M.'t.H.), Amsterdam University Medical Center, the Netherlands.; Department of General Practice (L.M.'t.H.), Amsterdam University Medical Center, the Netherlands., van den Maagdenberg AMJM; Department of Human Genetics (A.M.J.M.v.d.M.), Leiden University Medical Center, the Netherlands., van der Harst P; Department of Cardiology (P.v.d.H.), University Medical Center Groningen, the Netherlands., van der Horst ICC; Department of Critical Care (I.C.C.v.d.H.), University Medical Center Groningen, the Netherlands., van der Kallen CJH; Department of Internal Medicine, Maastricht University Medical Center, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.).; School for Cardiovascular Diseases (Cardiovascular Research Institute Maastricht [CARIM]), Maastricht University, Maastricht, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.)., van Greevenbroek MMJ; Department of Internal Medicine, Maastricht University Medical Center, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.).; School for Cardiovascular Diseases (Cardiovascular Research Institute Maastricht [CARIM]), Maastricht University, Maastricht, the Netherlands (C.D.A.S., C.J.H.v.d.K., M.M.J.v.G.)., van Spil WE; Department of Rheumatology and Clinical Immunology (W.E.v.S.), University Medical Center Utrecht, the Netherlands., Wijmenga C; Department of Genetics, University of Groningen, the Netherlands (M.S., M.A.S., C.W., A.Z.)., Zhernakova A; Department of Genetics, University of Groningen, the Netherlands (M.S., M.A.S., C.W., A.Z.)., Zwinderman AH; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, the Netherlands (A.H.Z.)., Sattar N; Institute of Cardiovascular and Medical Sciences, Cardiovascular Research Center, University of Glasgow, United Kingdom (N.S.)., Jukema JW; Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, the Netherlands., van Duijn CM; Department of Epidemiology (M.A.I., C.M.v.D.), Erasmus Medical Center, Rotterdam, the Netherlands., Boomsma DI; Department of Cardiology (S.T., J.W.J.), Leiden University Medical Center, the Netherlands.; Netherlands Twin Register, Department of Biological Psychology, Vrije University, Amsterdam (D.I.B.)., Reinders MJT; Department of Biomedical Data Sciences, Leiden Computational Biology Center (E.B.v.d.A., M.J.T.R.), Leiden University Medical Center, the Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, the Netherlands (E.B.v.d.A., M.J.T.R.)., Slagboom PE; Department of Molecular Epidemiology (E.B.v.d.A., J.J.H.B.W., M.B., H.E.D.S., J.D., D.C., H.M., I.M., L.M.'t.H., P.E.S.).; Max Planck Institute for Biology of Ageing, Cologne, Germany (J.D., P.E.S.).

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2020 Oct; Vol. 13 (5), pp. 541-547. Date of Electronic Publication: 2020 Aug 14.