Potentiation of C1 inhibitor by glycosaminoglycans: dextran sulfate species are effective inhibitors of in vitro complement activation in plasma

Autor: Wuillemin, W.A., te Velthuis, H., Lubbers, Y.T.P., de Ruig, C.P., Eldering, E.F., Hack, C.E.

Publikováno v: Journal of immunology (Baltimore, Md., 159(4), 1953-1960. American Association of Immunologists
The journal of immunology, 159, 1953-1960. American Association of Immunologists

Activation of the complement system may contribute to the pathogenesis of many diseases. Hence, an effective inhibitor of complement might be useful to reduce tissue damage. Some glycosaminoglycans (GAG), such as heparin, are known to inhibit the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f53661824c53215a1c33519eac12f46
https://doi.org/10.4049/jimmunol.159.4.1953

Discovery beyond the void: Energizing T cells in chronic lymphocytic leukemia

Autor: van Bruggen, J. A. C.

In the last decade, efficacy of treatment of chronic lymphocytic leukemia (CLL) has improved considerably. Highly effective targeted therapies such as ibrutinib and venetoclax have been developed and replaced chemoimmunotherapy as first-line treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::110e0c9a28bdeadf9dc212d346fd059e
https://dare.uva.nl/personal/pure/en/publications/discovery-beyond-the-void(a6e2dc22-0016-4da2-af30-b699ca5ec4ae).html

Making sense of genomic complexity and nonsense-RNA in hematologic malignancies

Autor: Leeksma, A.C.

The advent of novel efficacious but also expensive targeted agents has created an increased demand for more in-depth characterization and prognostication in chronic lymphocytic leukemia (CLL). Next-generation sequencing (NGS) analyses identified the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cfd7fe2de697366458e6094cc6037189
https://dare.uva.nl/personal/pure/en/publications/making-sense-of-genomic-complexity-and-nonsenserna-in-hematologic-malignancies(a211bfc9-f20d-429b-b850-b685ec64a442).html

The interplay between microenvironmental signaling and novel targeted drugs in CLL

Autor: Thijssen, R.

Despite the rapid expansion of novel treatment options, chronic lymphocytic leukemia (CLL) remains an incurable disease. Development of drug resistance is strongly influenced by the leukemic microenvironment within the lymph nodes and spleen. Within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0a5e7fbba4abb2493eb19157b58f9940
https://pure.amc.nl/en/publications/the-interplay-between-microenvironmental-signaling-and-novel-targeted-drugs-in-cll(45441a44-e68a-4797-8b12-ae157a248751).html

The microenvironment and treatment resistance in chronic lymphocytic leukemia

Autor: Tromp, J.M.

In de laatste jaren is er veel vooruitgang geboekt op het gebied van behandeling van chronische lymfatische leukemie (CLL), maar er bestaat tot op heden geen genezende (curatieve) behandeling. Resistentie tegen chemotherapie is nog steeds een groot p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::40baccda39c1fbddce8538aa9195ab30
https://dare.uva.nl/personal/pure/en/publications/the-microenvironment-and-treatment-resistance-in-chronic-lymphocytic-leukemia(898b8498-aea9-466e-9117-74d40880e4b6).html