Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elda Cannavo"'
Autor:
Giordano Reginato, Maria Rosaria Dello Stritto, Yanbo Wang, Jingzhou Hao, Raphael Pavani, Michael Schmitz, Swagata Halder, Vincent Morin, Elda Cannavo, Ilaria Ceppi, Stefan Braunshier, Ananya Acharya, Virginie Ropars, Jean-Baptiste Charbonnier, Martin Jinek, Andrè Nussenzweig, Taekjip Ha, Petr Cejka
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The outcome of CRISPR-Cas-mediated genome modifications is dependent on DNA double-strand break (DSB) processing and repair pathway choice. Homology-directed repair (HDR) of protein-blocked DSBs requires DNA end resection that is initiated b
Externí odkaz:
https://doaj.org/article/9468f29a4c104f0db450028e4975e766
Autor:
Lorenzo Galanti, Martina Peritore, Robert Gnügge, Elda Cannavo, Johannes Heipke, Maria Dilia Palumbieri, Barbara Steigenberger, Lorraine S. Symington, Petr Cejka, Boris Pfander
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract DNA double-strand breaks (DSBs) can be repaired by several pathways. In eukaryotes, DSB repair pathway choice occurs at the level of DNA end resection and is controlled by the cell cycle. Upon cell cycle-dependent activation, cyclin-dependen
Externí odkaz:
https://doaj.org/article/8bcb57ff610c4ff79e3b5f638390ffcf
Autor:
Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Antony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-termin
Externí odkaz:
https://doaj.org/article/8cecf44805f740329669d3853d59d8f7
Autor:
Antonio Marsella, Elisa Gobbini, Corinne Cassani, Renata Tisi, Elda Cannavo, Giordano Reginato, Petr Cejka, Maria Pia Longhese
Publikováno v:
Cell Reports, Vol 34, Iss 13, Pp 108906- (2021)
Summary: The Mre11-Rad50-Xrs2 (MRX) complex detects and processes DNA double-strand breaks (DSBs). Its DNA binding and processing activities are regulated by transitions between an ATP-bound state and a post-hydrolysis cutting state that is nucleolyt
Externí odkaz:
https://doaj.org/article/2daadc75ae19488e809716ef636b5a95
Autor:
Elda Cannavo, Dominic Johnson, Sara N. Andres, Vera M. Kissling, Julia K. Reinert, Valerie Garcia, Dorothy A. Erie, Daniel Hess, Nicolas H. Thomä, Radoslav I. Enchev, Matthias Peter, R. Scott Williams, Matt J. Neale, Petr Cejka
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection
Externí odkaz:
https://doaj.org/article/b5b662ab16c04fe787474e35772256f4
Autor:
Jesse D Deere, Robert C Kauffman, Elda Cannavo, Joanne Higgins, Andradi Villalobos, Lourdes Adamson, Raymond F Schinazi, Paul A Luciw, Thomas W North
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87914 (2014)
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated. The mechanisms of viral persistence during HAART are poorly
Externí odkaz:
https://doaj.org/article/6a5dec7323064294b4d342186b278c9a
Autor:
Jesse D Deere, Joanne Higgins, Elda Cannavo, Andradi Villalobos, Lourdes Adamson, Emilie Fromentin, Raymond F Schinazi, Paul A Luciw, Thomas W North
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11640 (2010)
To prevent progression to AIDS, persons infected with human immunodeficiency virus type 1 (HIV-1) must remain on highly active antiretroviral therapy (HAART) indefinitely since this modality does not eradicate the virus. The mechanisms involved in vi
Externí odkaz:
https://doaj.org/article/a2eec88abdca4b5fb5fd4613777254fa
Autor:
Ilaria Ceppi, Elda Cannavo, Hélène Bret, Rosa Camarillo, Francesca Vivalda, Roshan Singh Thakur, Amador Romero-Franco, Alessandro A. Sartori, Pablo Huertas, Raphaël Guérois, Petr Cejka
Publikováno v:
Genes & Development, 37 (3-4)
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11-RAD50-NBS1 (MRN) to endonucleolytically cleave 5'-terminated DNA to bypass protein blocks. CtIP also promotes the DNA2 helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac9824f539b89d495c328ea2f8a122d
https://hdl.handle.net/20.500.11850/605845
https://hdl.handle.net/20.500.11850/605845
Autor:
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre‐Henri Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Petr Cejka
Publikováno v:
The EMBO Journal. 42
The Werner Syndrome helicase, WRN, is a promising therapeutic target in cancers with microsatellite instability (MSI). Long-term MSI leads to the expansion of TA nucleotide repeats proposed to form cruciform DNA structures, which in turn cause DNA br
Autor:
Anthony W. Oliver, Freddy Khayat, Petr Cejka, William R. Foster, Christopher Smith, Antony M. Carr, Elda Cannavo, Alessandro Bianchi, Martino Maddalena, Charly Chahwan, Adam T. Watson, Majedh Alshmery
Publikováno v:
Nature Communications, 12 (1)
Nature Communications
Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The MRN complex (MRX in Saccharomyces cerevisiae, made of Mre11, Rad50 and Nbs1/Xrs2) initiates double-stranded DNA break repair and activates the Tel1/ATM kinase in the DNA damage response. Telomeres counter both outcomes at chromosome ends, partly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525380a9dccc24ae99484cf05c3bbe93
https://hdl.handle.net/20.500.11850/491589
https://hdl.handle.net/20.500.11850/491589