Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Elbert Chin"'
Autor:
Elbert Chin, Francisco Xavier Talamas, Jim Li, Kristen Lynn Mccaleb, Manjiri Ghate, Javier de Vicente, Ryan Craig Schoenfeld, Ken A. Brameld, Beihan Wang, Isabel Najera, Vincent Leveque, James Patrick Dunn, Sharada Labadie, Gloria Ao-Ieong, Anthony M. Giannetti, Alfred S-T. Lui, April Wong, Seth F. Harris
Publikováno v:
Journal of Medicinal Chemistry. 56:3115-3119
The use of fragments with low binding affinity for their targets as starting points has received much attention recently. Screening of fragment libraries has been the most common method to find attractive starting points. Herein, we describe a unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab6e023af501722154e0bbd4eade0c1d
https://doi.org/10.1021/jm4002605
https://doi.org/10.1021/jm4002605
Publikováno v:
Tetrahedron Letters. 51:6422-6425
A facile synthesis of a series of 1-alkoxyisoquinolines and (2H)-isoquinolones by an intramolecular 6-endo-dig cyclization of ortho-alkynylbenzonitriles in the presence of a catalytic amount of hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f296a7705d04e6b88e551f2d6c191a0
https://doi.org/10.1016/j.tetlet.2010.09.136
https://doi.org/10.1016/j.tetlet.2010.09.136
Publikováno v:
Organic Letters. 12:4712-4715
An expedient enantioselective synthesis of the Δ(4)-oxocene cores present in (+)-laurencin and (+)-prelaureatin was accomplished in eight steps via a novel one-pot regio- and stereoselective ring cyclization-fragmentation-expansion cascade from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33c32bd26b7c1a7ef2f98342edec1f
https://doi.org/10.1021/ol1021965
https://doi.org/10.1021/ol1021965
Autor:
Elbert Chin, Manjiri Ghate, Vincent Leveque, Sonal Rajyaguru, Bill Fitch, Jahari Laurant Tracy, Michael Brandl, Steve A. de Keczer, Ramona Hilgenkamp, Fell Jay Bradford, Tatyana Voronin, Isabel Najera, Gloria Ao-Ieong, Javier de Vicente, Shao-Yong Wu, Beihan Wang, Stacey Renee Spencer, Stengel Peter J, Peter Mohr, Mohammad R. Masjedizadeh, James F. Blake, Robert Than Hendricks, Todd R. Elworthy, David Bernard Smith, Junping Zhao, Ludmila Alexandrova, Robinson John E, Al Lui, John P. Fischer, Seth F. Harris, Jim Li, Connie Oshiro, Calvin Yee, Sophie Le Pogam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5648-5651
Benzothiazine-substituted tetramic acids were discovered as highly potent non-nucleoside inhibitors of HCV NS5B polymerase. X-ray crystallography studies confirmed the binding mode of these inhibitors with HCV NS5B polymerase. Rational optimization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7482cb6bce12ac0c2b982d6fc4cff88a
https://doi.org/10.1016/j.bmcl.2009.08.023
https://doi.org/10.1016/j.bmcl.2009.08.023
Autor:
Ludmila Alexandrova, Connie Oshiro, Ramona Hilgenkamp, Stengel Peter J, Isabel Najera, Peter Mohr, Jahari Laurant Tracy, Susan Larrabee, James F. Blake, David Bernard Smith, Bamberg Joe Timothy, George Adjabeng, Vincent Leveque, Andrew J. Briggs, Brian Xu, Seth F. Harris, Rebecca A. Stephenson, Sonal Rajyaguru, Manjiri Ghate, Beihan Wang, John P. Fischer, Stacey Renee Spencer, Calvin Yee, Sophie Le Pogam, Elbert Chin, Michael Brandl, Fell Jay Bradford, Gloria Ao-Ieong, Sunil Sukhtankar, Robert Than Hendricks, Jim Li, Robinson John E, Todd R. Elworthy, Farrell Robert P, Javier de Vicente
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3642-3646
A new series of benzothiazine-substituted quinolinediones were evaluated as inhibitors of HCV polymerase NS5B. SAR studies on this series revealed a methyl sulfonamide group as a high affinity feature. Analogues with this group showed submicromolar p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0673cb666121215e5519a1cfe7e1c9
https://doi.org/10.1016/j.bmcl.2009.05.004
https://doi.org/10.1016/j.bmcl.2009.05.004
Publikováno v:
Tetrahedron Letters. 51:5937-5939
A one-pot synthesis of phthalides via an intramolecular 5- exo-dig cyclization of ortho -alkynylbenzaldehydes under mild NaClO 2 oxidation conditions is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92b3a19967672fd64802adcb90808fe6
https://doi.org/10.1016/j.tetlet.2010.09.023
https://doi.org/10.1016/j.tetlet.2010.09.023
Autor:
Sophie Le Pogam, Isabel Najera, Junping Zhao, Sangi Michael, Taygerly Joshua Paul Gergely, Sandra Steiner, Francisco Xavier Talamas, Javier de Vicente, Ryan Craig Schoenfeld, Amy Fung, Elbert Chin, Alfred Sui-Ting Lui, David L. Bourdet, Vincent Leveque, Seth F. Harris, Sonal Rajyaguru, Ken A. Brameld, Eun Kyung Lee, Jim Li
Publikováno v:
Journal of medicinal chemistry. 56(20)
Hepatitis C virus (HCV) is a major global public health problem. While the current standard of care, a direct-acting antiviral (DAA) protease inhibitor taken in combination with pegylated interferon and ribavirin, represents a major advancement in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c14b5b2a8f775c539b574946acbe4d8
https://pubmed.ncbi.nlm.nih.gov/24069953
https://pubmed.ncbi.nlm.nih.gov/24069953
Autor:
Elbert Chin, Stephen R. Wilson
Publikováno v:
Fullerene Science and Technology. 4:43-48
The synthesis of radiolabeled C60/C70 for potential biochemical tracer studies was carried out. Vaporization under plasma are conditions (~3000C) of graphite rods impregnated with the 14C labeled steroid progesterone generates the expected C60/C70 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a70575aa48d4dadd44a5eb07bd471a
https://doi.org/10.1080/10641229608001536
https://doi.org/10.1080/10641229608001536
Publikováno v:
ChemInform. 42
1-Alkoxyisoquinolines as major products can be easily converted into isoquinolines by dealkylation with HBr in acetic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54005b68923c1737b8a404824493a5be
https://doi.org/10.1002/chin.201112148
https://doi.org/10.1002/chin.201112148
Publikováno v:
ChemInform. 42
The optimized conditions provide a broad spectrum of benzofuran derivatives and the pyridine analogue (X) in good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97429d26d2dcfef77bef666d0e260c74
https://doi.org/10.1002/chin.201107137
https://doi.org/10.1002/chin.201107137