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Avapritinib versus Placebo in Indolent Systemic Mastocytosis.

Autor: Gotlib J; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Castells M; Department of Medicine, Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston., Elberink HO; Department of Allergology, University Medical Center, Groningen Research Institute Asthma and COPD, University of Groningen, Groningen, the Netherlands., Siebenhaar F; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, Berlin., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Broesby-Olsen S; Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark., George TI; Associated Regional and University Pathologists, Inc. Laboratories, Department of Pathology, University of Utah School of Medicine, Salt Lake City., Panse J; Department of Oncology, Hematology, Hemostaseology, and Stem Cell Transplantation, University Hospital Aachen, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany.; Center for Integrated Oncology, Aachen, Bonn, Cologne, Düsseldorf (ABCD), Aachen, Germany., Alvarez-Twose I; Institute of Mastocytosis Studies of Castilla-La Mancha, Virgen del Valle Hospital, Toledo, Spain., Radia DH; Guy's & St. Thomas' National Health Service Foundation Trust, London., Tashi T; Huntsman Cancer Institute, University of Utah, Salt Lake City., Bulai Livideanu C; Department of Dermatology, Centre of Reference for Mastocytosis, Toulouse University Hospital, Toulouse, France., Sabato V; Department of Immunology, Allergology and Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerp, Belgium., Heaney M; Department of Medicine, Columbia University Medical Center, New York., Van Daele P; Department of Internal Medicine and Immunology, Erasmus Medical Center, Rotterdam, the Netherlands., Cerquozzi S; Department of Medicine, University of Calgary, Calgary, AB, Canada., Dybedal I; Department of Hematology, Oslo University Hospital, Oslo., Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Pongdee T; Division of Allergic Diseases, Mayo Clinic, Rochester, MN., Barete S; Unit of Dermatology, Centre of Reference for Mastocytosis, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne Université, Paris., Ustun C; Department of Internal Medicine, Division of Hematology, Oncology and Cell Therapy, Section of Bone Marrow Transplantation and Cellular Therapy, Rush Medical College, Chicago., Schwartz L; Virginia Commonwealth University, Richmond, VA., Ward BR; Virginia Commonwealth University, Richmond, VA., Schafhausen P; Department of Oncology, Hematology, and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Vadas P; Department of Medicine, Division of Clinical Immunology and Allergy, St. Michael's Hospital, University of Toronto, Toronto., Bose P; Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston., DeAngelo DJ; Dana-Farber Cancer Institute, Boston., Rein L; Department of Medicine, Duke University School of Medicine, Durham, NC., Vachhani P; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL., Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Bonadonna P; Allergy Unit and Asthma Center, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy., Rafferty M; The Beatson West of Scotland Cancer Centre, Glasgow, Scotland., Butt NM; The Clatterbridge Cancer Centre, Bebington, Wirral, United Kingdom., Oh ST; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, Washington University, St. Louis., Wortmann F; Oberärztin Hämatologie/Onkologie bei Uksh Campus Lübeck, Universitätsklinikum Schleswig-Holstein, Universität zu Lübeck, Lübeck, Schleswig-Holstein, Germany., Ungerstedt J; Department of Medicine, Huddinge (H7), Karolinska University Hospitale, Stockholm., Guilarte M; Hospital UniversitariVall d'Hebron, Institut de Recerca Vall d'Hebron (VHIR), Barcelona., Taparia M; University of Alberta, Edmonton, AB, Canada., Kuykendall AT; Department of Malignant Hematology, H. Lee Moffitt Cancer Center, Tampa, FL., Arana Yi C; Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ., Ogbogu P; Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland., Gaudy-Marqueste C; Service de Dermatologie et de cancérologie cutanée, Assistance Publique-Hopitaux de Marseille, Aix-Marseille Université, Marseille, France., Mattsson M; Department of Hematology, Uppsala University Hospital and Department of Immunology, Genetics and Pathology, Uppsala, Sweden., Shomali W; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Giannetti MP; Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston., Bidollari I; Blueprint Medicines Corporation, Cambridge, MA., Lin HM; Blueprint Medicines Corporation, Cambridge, MA., Sulllivan E; Blueprint Medicines Corporation, Cambridge, MA., Mar B; Blueprint Medicines Corporation, Cambridge, MA., Scherber R; Blueprint Medicines Corporation, Cambridge, MA., Roche M; Blueprint Medicines Corporation, Cambridge, MA., Akin C; University of Michigan, Ann Arbor, MI., Maurer M; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin.; Fraunhofer Institute for Translational Medicine and Pharmacology, Allergology and Immunology, Berlin.

Publikováno v: NEJM evidence [NEJM Evid] 2023 Jun; Vol. 2 (6), pp. EVIDoa2200339. Date of Electronic Publication: 2023 May 23.

Prognostic Impact of Organomegaly in Mastocytosis: An Analysis of the European Competence Network on Mastocytosis.

Autor: Lübke J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Christen D; Department of Oncology, Haematology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany., Elberink HO; Department of Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Span B; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Niedoszytko M; Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland., Gorska A; Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland., Lange M; Department of Dermatology, Medical University of Gdańsk, Gdańsk, Poland., Gleixner KV; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Hadzijusufovic E; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria; Internal Medicine Small Animals, University Clinic for Small Animals, Department/University Clinic for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria., Solomianyi O; University Clinic for Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Angelova-Fischer I; Department of Dermatology and Venereology, Allergy Center, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria., Zanotti R; Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy., Bonifacio M; Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy., Bonadonna P; Allergy Unit, Verona University Hospital, Verona, Italy., Shoumariyeh K; Department of Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, Germany., von Bubnoff N; Department of Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, Germany; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Müller S; Department of Dermatology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Perkins C; Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Elena C; Department of Molecular Medicine and Department of Hematology Oncology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Malcovati L; Department of Molecular Medicine and Department of Hematology Oncology, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Hagglund H; Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Mattsson M; Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Parente R; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Varkonyi J; Department of Hematology, Semmelweis University, Budapest, Hungary., Fortina AB; Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy., Caroppo F; Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy., Zink A; Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technische Universität München, Munich, Germany., Brockow K; Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technische Universität München, Munich, Germany., Breynaert C; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium., Bullens D; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium., Yavuz AS; Division of Hematology, Istanbul Medical School, University of Istanbul, Istanbul, Turkey., Doubek M; University Hospital and Faculty of Medicine, Brno, Czechia., Sabato V; Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerpen, Belgium., Schug T; Department of Dermatology and Venereology, University Hospital Graz, Graz, Austria., Niederwieser D; University Hospital of Leipzig, Leipzig, Germany., Hartmann K; Division of Allergy, Department of Dermatology, University of Basel, Basel, Switzerland; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Gotlib J; Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Hermine O; French Reference Center for Mastocytosis (CEREMAST), Hôpital Necker, Assistance Publique Hôpitaux de Paris, Imagine Institute, University Paris Descartes, Paris, France., Arock M; Laboratory of Hematology, Pitié-Salpêtrière Hospital, Paris, France., Kluin-Nelemans HC; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Panse J; Department of Oncology, Haematology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany., Sperr WR; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Valent P; Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Jawhar M; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: mohamad.jawhar@medma.uni-heidelberg.de.

Publikováno v: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2023 Feb; Vol. 11 (2), pp. 581-590.e5. Date of Electronic Publication: 2022 Nov 17.

Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond.

Autor: Jennings SV; The Mast Cell Disease Society, Inc. (DBA The Mastocytosis Society, Inc.), Sterling, Mass. Electronic address: susan.jennings@tmsforacure.org., Finnerty CC; The Mast Cell Disease Society, Inc. (DBA The Mastocytosis Society, Inc.), Sterling, Mass; Department of Surgery, University of Texas Medical Branch, Galveston, Texas., Hobart JS; The UK Mastocytosis Support Group, London, United Kingdom., Martín-Martínez M; Spanish Association of Mastocytosis and Related Diseases (AEDM), Madrid, Spain; Medicinal Chemistry Institute (IQM-CSIC), Madrid, Spain., Sinclair KA; The Australasian Mastocytosis Society, Port Macquarie, New South Wales, Australia., Slee VM; The Mast Cell Disease Society, Inc. (DBA The Mastocytosis Society, Inc.), Sterling, Mass., Agopian J; French Association for Research Initiatives on Mast Cells and Mastocytosis (AFIRMM), Paris, France., Akin C; Division of Allergy and Clinical Immunology, Department of Medicine, University of Michigan, Ann Arbor, Mich., Álvarez-Twose I; Institute of Mastocytosis Studies of Castilla-La Mancha (CLMast) and CIBERONC, Virgen del Valle Hospital, Toledo, Spain; Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain., Bonadonna P; Allergy Unit, Verona University Hospital, Verona, Italy., Bowman AS; The Mast Cell Disease Society, Inc. (DBA The Mastocytosis Society, Inc.), Sterling, Mass; Department of Health and Human Performance, Middle Tennessee State University, Murfreesboro, Tenn., Brockow K; Department of Dermatology and Allergy Biederstein, Faculty of Medicine, Technical University of Munich, Munich, Germany., Bumbea H; European Center of Excellence in Mastocytosis, Hematological Rare Disease Center, Department of Hematology, Emergency University Hospital Bucharest, Bucharest, Romania., de Haro C; Mexican Association of Mastocytosis, AC, Mexico City, Mexico., Fok JS; Allergy and Clinical Immunology, Box Hill Hospital, Eastern Health, Box Hill, Victoria, Australia; Immunology and Allergy, Monash Medical Centre, Monash Health, Clayton, Victoria, Australia., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland., Hegmann N; Mastocytosis Self-Support Network, eV, Odenthal, Germany., Hermine O; Imagine Institute Université de Paris Descartes, Sorbonne, Institut National de la Santé et de la Recherche Médicale, Centre National de Référence des Mastocytoses (CEREMAST), Hôpital Necker, Assistance Publique Hôpitaux de Paris, Paris, France., Kalisiak M; Mastocytosis Society Poland, Warsaw, Poland., Katelaris CH; Department of Medicine, Immunology and Allergy Unit, Campbelltown Hospital, Campbelltown, New South Wales, Australia; Immunology and Allergy Unit, School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia., Kurz J; Mastocytosis Self-Support Network, eV, Odenthal, Germany., Marcis P; Italian Mastocytosis Association, Turin, Italy., Mayne D; The Australasian Mastocytosis Society, Port Macquarie, New South Wales, Australia., Mendoza D; Pediatric Allergy and Clinical Immunology, Instituto Nacional de Pediátria, Mexico City, Mexico., Moussy A; French Association for Research Initiatives on Mast Cells and Mastocytosis (AFIRMM), Paris, France., Mudretzkyj G; Austrian Mastocytosis Support Group, Vienna, Austria., Vaia NN; Mastocytosis Support Association Romania, Bucharest, Romania., Niedoszytko M; Allergology Department, Medical University of Gdansk, Gdansk, Poland., Elberink HO; Department of Allergology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Orfao A; Spanish Network on Mastocytosis (REMA), Toledo and Salamanca, Spain; Servicio Central de Citometria, Centro de Investigacion del Cancer (IBMCC; CSIC/USAL), Instituto Biosanitario de Salamanca (IBSAL), CIBERONC and Department of Medicine, University of Salamanca, Salamanca, Spain., Radia DH; Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom., Rosenmeier S; Austrian Mastocytosis Support Group, Vienna, Austria., Ribada E; Spanish Association of Mastocytosis and Related Diseases (AEDM), Madrid, Spain., Schinhofen W; Self-Support Association Mastocytosis eV, Toenisvorst, Germany., Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Mannheim, Germany., Siebenhaar F; Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany., Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Tripodo G; Italian Mastocytosis Association, Turin, Italy., Velazquez R; Mexican Association of Mastocytosis, AC, Mexico City, Mexico., Wielink Y; Mastocytosis Association Netherlands, Almere, The Netherlands., Wimazal F; Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria., Yigit T; Self-Support Association Mastocytosis eV, Toenisvorst, Germany., Zubrinich C; Allergy and Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.

Publikováno v: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2022 Aug; Vol. 10 (8), pp. 2039-2051. Date of Electronic Publication: 2022 Jun 28.

Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference.

Autor: Gotlib J; Division of Hematology, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, Calif. Electronic address: jason.gotlib@stanford.edu., George TI; Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah., Carter MC; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., Austen KF; Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, Mass., Bochner B; Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill., Dwyer DF; Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, Mass., Lyons JJ; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., Hamilton MJ; Division of Gastroenterology, Hepatology and Endoscopy. Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., Butterfield J; Mayo Clinic, Division of Allergic Diseases, Rochester, Minn., Bonadonna P; Allergy Unit, Verona University Hospital, Verona, Italy., Weiler C; Mayo Clinic, Division of Allergic Diseases, Rochester, Minn., Galli SJ; Department of Pathology, Stanford University School of Medicine, Stanford, Calif; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, Calif., Schwartz LB; Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Virginia Commonwealth University, Richmond, Va., Elberink HO; Internal Medicine, Section Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Maitland A; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Theoharides T; Department of Immunology, Tufts University School of Medicine, Boston, Mass., Ustun C; Division of Hematology, Oncology and Cellular Therapy, Department of Medicine, Rush University, Chicago, Ill., Horny HP; Institute of Pathology, Ludwig-Maximilian-University, Munich, Germany., Orfao A; Servicio Central de Citometria, Centro de Investigacion del Cancer (IBMCC, CSIC/USAL), IBSAL, CIBERONC and Department of Medicine, University of Salamanca, Salamanca, Germany., Deininger M; Division of Hematology and Hematologic Malignancies, The University of Utah, and Huntsman Cancer Institute, Salt Lake City, Utah., Radia D; Department of Clinical Haematology, Guys and St Thomas' NHS Hospitals, London, United Kingdom., Jawhar M; University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Kluin-Nelemans H; Department of Haematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Metcalfe DD; Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., Arock M; Laboratory of Haematology, Pitié-Salpêtrière Hospital, Paris, France., Sperr WR; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Castells M; Brigham and Women's Hospital, Division of Allergy and Clinical Immunology, Boston, Mass; Harvard Medical School, Boston, Mass., Akin C; Division of Allergy and Immunology, University of Michigan, Ann Arbor, Mich.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jun; Vol. 147 (6), pp. 2043-2052. Date of Electronic Publication: 2021 Mar 11.