Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

Autor: Sperandio, David, Aktoudianakis, Vangelis, Babaoglu, Kerim, Chen, Xiaowu, Elbel, Kristyna, Chin, Gregory, Corkey, Britton, Du, Jinfa, Jiang, Bob, Kobayashi, Tetsuya, Mackman, Richard, Martinez, Ruben, Yang, Hai, Zablocki, Jeff, Kusam, Saritha, Jordan, Kim, Webb, Heather, Bates, Jamie G., Lad, Latesh, Mish, Michael, Niedziela-Majka, Anita, Metobo, Sammy, Sapre, Annapurna, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Kan, Elaine, Eisenberg, Gene, Larson, Nate, Newby, Zachary E.R., Lansdon, Eric, Tay, Chin, Neve, Richard M., Shevick, Sophia L., Breckenridge, David G.

Publikováno v: In Bioorganic & Medicinal Chemistry 1 February 2019 27(3):457-469

Synthesis of Caged Garcinia Xanthones and Rational Design of Fluorescent Sensors for Amyloid Detection

Autor: Elbel, Kristyna M.

Publikováno v: Elbel, Kristyna M.(2013). Synthesis of Caged Garcinia Xanthones and Rational Design of Fluorescent Sensors for Amyloid Detection /. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4gz3c8mp

The family of caged Garcinia xanthones (CGX) possess a unique chemical structure along with promising antitumor and anti-inflammatory pharmacological profiles. We report the synthesis and biological evaluation of A-ring oxygenated structures related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::998d65e38750f62b69eee453c1abb46a
http://n2t.net/ark:/20775/bb78855065

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