Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elbek K. Kurbanov"'
Autor:
Kim D. Janda, Margaret E. Olson, Eric A. Johnson, Karen N. Allen, Sabine Pellett, Lewis D. Turner, Margarita A. Tararina, Elbek K Kurbanov, Alexander L. Nielsen, Lucy Lin, Seth M. Cohen, Takashi Sugane
Publikováno v:
J Med Chem
Journal of medicinal chemistry, vol 63, iss 19
Journal of medicinal chemistry, vol 63, iss 19
Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small molecule inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores — a zinc binding group and a Cys-reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a30c3a2ca2f724a7d20508cb5271630
https://europepmc.org/articles/PMC7581224/
https://europepmc.org/articles/PMC7581224/
Autor:
Michael A. Walters, Ting Lan Chiu, Barry C. Finzel, Jon E. Hawkinson, Jonathan Solberg, Rodney L. Johnson, Elbek K. Kurbanov, Elizabeth A. Amin, Kimberly M. Maize, Jenna Fernandez, Subhashree Francis
Publikováno v:
Journal of Medicinal Chemistry. 58:8723-8733
The lethal factor (LF) enzyme secreted by Bacillus anthracis is a zinc hydrolase that is chiefly responsible for anthrax-related cell death. Although many studies of the design of small molecule LF inhibitors have been conducted, no LF inhibitor is y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e437229548a785354f0d64762cefae0
https://doi.org/10.1021/acs.jmedchem.5b01446
https://doi.org/10.1021/acs.jmedchem.5b01446
Publikováno v:
Journal of Chemical Theory and Computation. 9:2617-2628
In the present paper, we apply the electrostatically embedded many-body expansion of the correlation energy (EE-MB-CE) to the calculation of zinc-ligand and cadmium-ligand bond dissociation energies, and we analyze the errors due to various fragmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1095ba0036c1499e00d65f18dcba552e
https://doi.org/10.1021/ct4001872
https://doi.org/10.1021/ct4001872
Publikováno v:
Journal of Chemical Theory and Computation. 8:1-5
The electrostatically embedded many-body (EE-MB) method has proven accurate for calculating cohesive and conformational energies in clusters, and it has recently been extended to obtain bond dissociation energies for metal–ligand bonds in positivel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca75d77814eb13f53b7c9e28b5b29bf
https://doi.org/10.1021/ct200637v
https://doi.org/10.1021/ct200637v
Publikováno v:
FEBS letters. 589(24 Pt)
The Bacillus anthracis lethal factor (LF) is one component of a tripartite exotoxin partly responsible for persistent anthrax cytotoxicity after initial bacterial infection. Inhibitors of the zinc metalloproteinase have been investigated as potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8071c52c81b2bf327413b46012759d4
https://pubmed.ncbi.nlm.nih.gov/26578066
https://pubmed.ncbi.nlm.nih.gov/26578066
Autor:
Elbek K. Kurbanov, Teresa De la Mora-Rey, Kimberly M. Maize, Dong Jin Hwang, Michael A. Walters, Todd W. Geders, Rodney L. Johnson, Elizabeth A. Amin, Barry C. Finzel
The secreted anthrax toxin consists of three components: the protective antigen (PA), edema factor (EF) and lethal factor (LF). LF, a zinc metalloproteinase, compromises the host immune system primarily by targeting mitogen-activated protein kinase k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abaf8427bc0555b46413d4bfe5dee4c
https://europepmc.org/articles/PMC4220970/
https://europepmc.org/articles/PMC4220970/