Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elayne Provost"'
Autor:
Megan H. Cleveland, Ross W. Bittman, Jeffrey C. Roeser, Elayne Provost, Audrey M. Hendley, Anirban Maitra, Steven D. Leach, Yue J. Wang, Jennifer M. Bailey, Albert B. Reynolds, Danielle Blake
Publikováno v:
Developmental Biology. 399:41-53
The intracellular protein p120 catenin aids in maintenance of cell–cell adhesion by regulating E-cadherin stability in epithelial cells. In an effort to understand the biology of p120 catenin in pancreas development, we ablated p120 catenin in mous
Autor:
Jennifer M. Bailey, Shu Liu, Sumar Aldrugh, Christine A. Iacobuzio-Donahue, Elayne Provost, Steven D. Leach
Publikováno v:
Zebrafish. 11:551-559
Ribosomal proteins are known to be required for proper assembly of mature ribosomes. Recent studies indicate an additional role for ribosomal proteins as candidate tumor suppressor genes. Pancreatic acinar cells, recently identified as effective cell
Publikováno v:
Zebrafish. 10:161-169
Ribosomal protein L (rpl) genes are essential for assembly of the 60S subunit of the eukaryotic ribosome and may also carry out additional extra-ribosomal functions. We have identified a common expression pattern for rpl genes in developing zebrafish
Autor:
Rachel Green, Elayne Provost, Foram N. Ashar, Xiangang Zhong, Karen A. Wehner, Elizabeth Dong Nguyen, Michael J. Parsons, Steven D. Leach
Publikováno v:
Development. 139:3232-3241
Mutations in the human Shwachman-Bodian-Diamond syndrome (SBDS) gene cause defective ribosome assembly and are associated with exocrine pancreatic insufficiency, chronic neutropenia and skeletal defects. However, the mechanism underlying these phenot
Publikováno v:
Angewandte Chemie International Edition. 51:6908-6911
Deciphering the molecular mechanisms that underlie embryogenesis requires an ability to alter gene function with spatial and temporal precision. Synthetic reagents can be valuable tools in this discovery process, especially in model organisms current
Autor:
Jennifer L. Anderson, Elayne Provost, Steven A. Farber, Amy L. Rubinstein, Kotaro Hama, Steven D. Leach, Timothy C. Baranowski
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G445-G453
Optical clarity of larvae makes the zebrafish ideal for real-time analyses of vertebrate organ function through the use of fluorescent reporters of enzymatic activities. A key function of digestive organs is to couple the generation of enzymes with m
Publikováno v:
genesis. 45:625-629
We have adapted a novel multicistronic gene expression system involving viral peptides to the zebrafish. The viral 2A peptide allows production of multiple protein products from a single transgene. Based on highly inefficient peptide bond formation b
Autor:
Allen Shearn, Elayne Provost
Publikováno v:
Journal of Bioenergetics and Biomembranes. 38:189-195
The prune-Killer of prune conditional dominant, lethal interaction in Drosophila was identified in the 1950s, but its mechanism remains unknown. We undertook a genetic screen for suppressors of this lethal interaction and identified a gene we named,
Autor:
Allen Shearn, Lisa Timmons, Wen Qi Ho, Elayne Provost, Grafton Hersperger, Evelyn Hersperger, Rosa Alcazar
Publikováno v:
Genetics. 172:207-219
The prune gene of Drosophila melanogaster is predicted to encode a phosphodiesterase. Null alleles of prune are viable but cause an eye-color phenotype. The abnormal wing discs gene encodes a nucleoside diphosphate kinase. Killer of prune is a missen
Autor:
Bruce G. Haffty, Amanda Psyrri, Ziwei Yu, David L. Rimm, Paul M. Weinberger, Elayne Provost, Clarence T. Sasaki, Robert L. Camp, John K. Joe
Publikováno v:
Clinical Cancer Research. 11:2471-2477
Background: β-catenin, depending on subcellular localization, plays a dual role in carcinogenesis: as a signaling factor (in the nucleus) and as an adhesion molecule (in cell membrane). In this study, we sought to determine the role of β-catenin in