Výsledky vyhledávání - "Elayne Penebre"

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing

Autor: Rocio Montes de Oca, Christopher L. Carpenter, Michael T. McCabe, Christine Thompson, Ann Boriack-Sjodin, Xi-Ping Zhang, Wendy A. Kellner, Kenneth W. Duncan, Melissa B. Pappalardi, Sarah Gerhart, Olena Barbash, Johnson Neil W, Ryan G. Kruger, BaoChau Le, Christina R. Majer, Elayne Penebre

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)

Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee7358da85da77db0efa39b1bb61fdd
https://doi.org/10.1038/s41598-018-28002-y

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Abstract B85: EZH2 plays a critical role in B-cell maturation and in non-Hodgkin's lymphoma: Interplay between EZH2 function and B-cell activation

Autor: Trupti Lingaraj, Alison Drew, Danielle Johnston, Scott Ribich, Alejandra Raimondi, Dorothy Brach, Sarah K. Knutson, Heike Keilhack, Christopher Plescia, Natalie Warholic, Robert A. Copeland, J. Joshua Smith, Elayne Penebre, Michael Thomenius

Publikováno v: Molecular Cancer Therapeutics. 14:B85-B85

The EZH2 inhibitor tazemetostat (EPZ-6438) is emerging as a promising therapeutic agent for the treatment of non-Hodgkin's Lymphoma (NHL). A significant body of work has now demonstrated in vitro and in vivo effects of EZH2 inhibition in preclinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e2c75d285a6e354196cddb94e68049f
https://doi.org/10.1158/1535-7163.targ-15-b85

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Abstract LB-248: Protein arginine methyltransferase 5 (PRMT5) inhibition as a therapeutic strategy in B-cell lymphoma

Autor: Jesse Smith, David Soong, Kristy G Kuplast, Christine Thompson, Olena Barbash, Elayne Penebre, Rocio Montes de Oca, Christina R. Majer, Christopher L. Carpenter, Charles F. McHugh, Ryan G. Kruger, Kenneth W. Duncan, Robert A. Copeland, Richard Chesworth, Neil F. Johnson, Sarah Gerhart, Ping Zhang

Publikováno v: Cancer Research. 75:LB-248

PRMT5 is responsible for symmetric dimethylation of arginine residues in glycine and arginine rich (GAR) motifs on a variety of cytosolic and nuclear proteins including histones, spliceosome components, regulators of translation, transcription factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd47649121ed3b12bab388fda4e64230
https://doi.org/10.1158/1538-7445.am2015-lb-248

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