Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Elangovan, Manivannan"'
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 70 (2022)
CP-225917 was isolated from unidentified fungi and exhibits farnesyl transferase and squalene synthase inhibitory activity. In the present investigation, computational studies including docking, molecular dynamic simulations, protein ligand interacti
Externí odkaz:
https://doaj.org/article/e9f48c7fd4d1418eac3b4f4f59686beb
Autor:
Elangovan Manivannan, Chandrabose Karthikeyan, N. S. Hari Narayana Moorthy, Subash Chandra Chaturvedi
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The emergence and rapid spread of novel coronavirus disease (COVID-19) has posed a serious challenge to global public health in 2020. The speed of this viral spread together with the high mortality rate has caused an unprecedented public health crisi
Externí odkaz:
https://doaj.org/article/96ed76a77efa4646a9a4a51bc2a9508b
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
COVID-19 pandemic has spread worldwide at an exponential rate affecting millions of people instantaneously. Currently, various drugs are under investigation to treat an enormously increasing number of COVID-19 patients. This dreadful situation clearl
Externí odkaz:
https://doaj.org/article/c77b2f28813d414c9e03f0529c1d5a05
Autor:
Shweta Jakhmola, Omkar Indari, Dharmendra Kashyap, Nidhi Varshney, Ayan Das, Elangovan Manivannan, Hem Chandra Jha
Publikováno v:
Heliyon, Vol 7, Iss 3, Pp e06572- (2021)
SARS-CoV-2 transmissibility is higher than that of other human coronaviruses; therefore, it poses a threat to the populated communities. We investigated mutations among envelope (E), membrane (M), and spike (S) proteins from different isolates of SAR
Externí odkaz:
https://doaj.org/article/a786324d28e74b89959f73ba2e568945
Autor:
Sanna Niinivehmas, Pekka A. Postila, Sanna Rauhamäki, Elangovan Manivannan, Sami Kortet, Mira Ahinko, Pasi Huuskonen, Niina Nyberg, Pasi Koskimies, Sakari Lätti, Elina Multamäki, Risto O. Juvonen, Hannu Raunio, Markku Pasanen, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 743-754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HS
Externí odkaz:
https://doaj.org/article/ca9ca7ff4f1a4f61961e932f9fb13641
Autor:
Haneen Amawi, Noor A. Hussein, Charles R. Ashby, Rawan Alnafisah, Leticia M. Sanglard, Elangovan Manivannan, Chandrabose Karthikeyan, Piyush Trivedi, Kathryn M. Eisenmann, Robert W. Robey, Amit K. Tiwari
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The inhibition of apoptosis, disruption of cellular microtubule dynamics, and over-activation of the epithelial mesenchymal transition (EMT), are involved in the progression, metastasis, and resistance of colorectal cancer (CRC) to chemotherapy. Ther
Externí odkaz:
https://doaj.org/article/86a51d937140401c9b94dea85fccb2a0
Autor:
Sanna Rauhamäki, Pekka A. Postila, Sanna Niinivehmas, Sami Kortet, Emmi Schildt, Mira Pasanen, Elangovan Manivannan, Mira Ahinko, Pasi Koskimies, Niina Nyberg, Pasi Huuskonen, Elina Multamäki, Markku Pasanen, Risto O. Juvonen, Hannu Raunio, Juhani Huuskonen, Olli T. Pentikäinen
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depress
Externí odkaz:
https://doaj.org/article/7ce7e89c445b4b708ee76689792f6021
Publikováno v:
Coronaviruses. 3
Abstract: Coronaviruses are a leading cause of emerging life-threatening diseases, as evidenced by the ongoing coronavirus disease pandemic (COVID-19). According to complete genome sequence analysis reports, severe acute respiratory syndrome coronavi
Autor:
Haneen Amawi, Noor A. Hussein, Chandrabose Karthikeyan, Elangovan Manivannan, Alexander Wisner, Frederick E. Williams, Temesgen Samuel, Piyush Trivedi, Charles R. Ashby, Amit K. Tiwari
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
This study was designed to determine the in vitro mechanisms by which the novel silybin derivative, (E)-3-(3-(benzyloxy) phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (HM015k or 15k), produces its anticancer efficacy in ovarian cancer cells. Compound 15
Externí odkaz:
https://doaj.org/article/a3b934fda197491db8f642def03f4e85
Autor:
Chandrabose Karthikeyan, Sandeep Jain, N S Hari Moorthy, Elangovan Manivannan, Laurent Meijer, Piyush Trivedi
Publikováno v:
Proceedings of 7th International Electronic Conference on Medicinal Chemistry.