Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Elamparithi Jayamani"'
Autor:
Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, Annie L Conery, Wooseong Kim, Elamparithi Jayamani, Bumsup Kwon, Frederick M Ausubel, Eleftherios Mylonakis
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124595 (2015)
Staphylococcus aureus is a Gram-positive bacterium that has become the leading cause of hospital acquired infections in the US. Repurposing Food and Drug Administration (FDA) approved drugs for antimicrobial therapy involves lower risks and costs com
Externí odkaz:
https://doaj.org/article/e508126ab2f24e3d84bae75cb2312ee8
Autor:
Rajmohan Rajamuthiah, Elamparithi Jayamani, Annie L Conery, Beth Burgwyn Fuchs, Wooseong Kim, Tatiana Johnston, Andreas Vilcinskas, Frederick M Ausubel, Eleftherios Mylonakis
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128576 (2015)
The red flour beetle Tribolium castaneum is a common insect pest and has been established as a model beetle to study insect development and immunity. This study demonstrates that defensin 1 from T. castaneum displays in vitro and in vivo antimicrobia
Externí odkaz:
https://doaj.org/article/104c94db8fee4559bf3f2568e1aba004
Autor:
Xiaojiang Tan, Beth Burgwyn Fuchs, Yan Wang, Weiping Chen, Grace J Yuen, Rosalyn B Chen, Elamparithi Jayamani, Cleo Anastassopoulou, Read Pukkila-Worley, Jeffrey J Coleman, Eleftherios Mylonakis
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94468 (2014)
Candida albicans is a ubiquitous fungus, which can cause very serious and sometimes life-threatening infections in susceptible patients. We used Caenorhabditis elegans as a model host to screen a library of C. albicans mutants for decreased virulence
Externí odkaz:
https://doaj.org/article/df867dbe221d406dadb9e8d2ec8e24c0
Autor:
Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, Elamparithi Jayamani, Younghoon Kim, Jonah Larkins-Ford, Annie Conery, Frederick M Ausubel, Eleftherios Mylonakis
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89189 (2014)
Staphylococcus aureus, the leading cause of hospital-acquired infections in the United States, is also pathogenic to the model nematode Caenorhabditis elegans. The C. elegans-S. aureus infection model was previously carried out on solid agar plates w
Externí odkaz:
https://doaj.org/article/391ed0c1619d4ce28523da867af0548d
Autor:
J. Amaranath Govindan, Elamparithi Jayamani, Xinrui Zhang, Peter Breen, Jonah Larkins-Ford, Eleftherios Mylonakis, Gary Ruvkun
Publikováno v:
Nature Cell Biology. 24:1005-1007
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175a18e2c825589d2a8515fa4a191459
https://doi.org/10.1038/s41556-022-00868-1
https://doi.org/10.1038/s41556-022-00868-1
Publikováno v:
Proceedings of the National Academy of Sciences. 116:21651-21658
Caenorhabditis elegans consumes bacteria, which can supply essential vitamins and cofactors, especially for mitochondrial functions that have a bacterial ancestry. Therefore, we screened the Keio Escherichia coli knockout library for mutations that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::500cb8d490167756237b69f5dde0a4a1
https://doi.org/10.1073/pnas.1912628116
https://doi.org/10.1073/pnas.1912628116
Autor:
Elamparithi Jayamani, Gary Ruvkun, J. Amaranath Govindan, Jack W. Szostak, Victor S. Lelyveld
Microbial toxins and virulence factors often target the eukaryotic translation machinery. Caenorhabditis elegans surveils for such microbial attacks by monitoring translational competence, and if a deficit is detected, particular drug detoxification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233978cad6ac1de578860e9c6d888d9c
https://doi.org/10.1101/2020.01.08.898668
https://doi.org/10.1101/2020.01.08.898668
C. elegansconsumes bacteria which can supply essential vitamins and cofactors especially for mitochondrial functions ancestrally related to bacteria. Therefore, we screened the KeioE. coliknockout library for mutations that induce aC. elegansmitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3d5ee38076ca2adf0a165cf7fa7f60
https://doi.org/10.1101/707968
https://doi.org/10.1101/707968
Autor:
Wooseong Kim, Nico Fricke, Huajian Gao, William M. Wuest, Erika E Csatary, Bumsup Kwon, Frederick M. Ausubel, Andrew D. Steele, Madeline M Dekarske, Elamparithi Jayamani, Wen Pan, Petia M. Vlahovska, Annie L. Conery, Wenpeng Zhu, Jake L Rosen, Beth Burgwyn Fuchs, Isabelle Sinitsa, Eleftherios Mylonakis
Conventional antibiotics are not effective in treating infections caused by drug-resistant or persistent nongrowing bacteria, creating a dire need for the development of new antibiotics. We report that the small molecule nTZDpa, previously characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f0e34866439648dea6accbe29a166e
https://europepmc.org/articles/PMC6468991/
https://europepmc.org/articles/PMC6468991/
Autor:
Bumsup Kwon, Wooseong Kim, Rajmohan Rajamuthiah, Eleftherios Mylonakis, Annie L. Conery, Beth Burgwyn Fuchs, Hiwa Majed, Frederick M. Ausubel, Michael J. Kelso, Elamparithi Jayamani
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5203-5207
The emergence of multidrug-resistant bacterial strains has heightened the need for new antimicrobial agents based on novel chemical scaffolds that are able to circumvent current modes of resistance. We recently developed a whole-animal drug-screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d53c406dd235c413570df06676534e
https://doi.org/10.1016/j.bmcl.2015.09.066
https://doi.org/10.1016/j.bmcl.2015.09.066