Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Elamipretide"'
SS-31 protects diabetic nephropathy progression: A systematic review of in vivo and in vitro studies
Autor:
Jonathan Christianto Sutadji, Dian Anggraini Permatasari Musalim, David Setyo Budi, Jennifer Susanto, Fanny Gunawan, Chaq El Chaq Zamzam Multazam, Citrawati Dyah Kencono Wungu
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 12, Iss 5, Pp 956-971 (2024)
Context: Diabetic nephropathy is the leading cause of end-stage renal disease and also death in the world. Administration of Szeto-Schiller-31 (SS-31) as a potential therapeutic candidate that can decrease the renal function damage progressivity in d
Externí odkaz:
https://doaj.org/article/aa1589c433214f1598dca3ff2ac93bca
Publikováno v:
Clinical Case Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)
Key Clinical Message This case report presents a progressively declining 17‐year‐old patient with membrane protein‐associated neurodegeneration who demonstrated symptomatic improvements in her dysarthria, dysphagia, and gait, and objective impr
Externí odkaz:
https://doaj.org/article/a54e1e49d0fa470fb19e766fadeea974
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 176, Iss , Pp 116804- (2024)
Acute kidney injury (AKI) is associated with both kidney function loss and increased mortality. In the pathological progression of ischemia-reperfusion-induced AKI, the surge of reactive oxygen species (ROS) plays a crucial role. To combat this, mito
Externí odkaz:
https://doaj.org/article/b62fa6130f974a0b90eb12a506b4973f
Publikováno v:
Iraqi Journal of Pharmaceutical Sciences, Vol 33, Iss 2 (2024)
Doxorubicin (DOX) has been used to treat malignant diseases for over 40 years. The main constraint to its clinical application is dose-dependent cardiotoxicity which is regarded as a major matter of concern that limits its medical usefulness. Mitocho
Externí odkaz:
https://doaj.org/article/0e5ed7829da24102b8d4716e9b1cff8a
Publikováno v:
Cells, Vol 13, Iss 14, p 1168 (2024)
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by mutations to the dystrophin gene, resulting in deficiency of dystrophin protein, loss of myofiber integrity in skeletal and cardiac muscle, and eventual cell death and
Externí odkaz:
https://doaj.org/article/3052f6ea53aa4bc48939dd60b4ae7440
Autor:
Mary Kay Koenig, Sam Nick Russo, Kim L. McBride, Hans Tomas Bjornsson, Brynja Bjork Gunnarsdottir, Amy Goldstein, Scott A. Falk
Publikováno v:
JIMD Reports, Vol 64, Iss 1, Pp 65-70 (2023)
Abstract Several mitochondrial diseases are caused by pathogenic variants that impair membrane phospholipid remodeling, with no FDA‐approved therapies. Elamipretide targets the inner mitochondrial membrane where it binds to cardiolipin, resulting i
Externí odkaz:
https://doaj.org/article/2a1b65d79cfc44da9295673fe3a0a559
Autor:
Brittany Hornby, William Reid Thompson, Mohammed Almuqbil, Ryan Manuel, Anthony Abbruscato, Jim Carr, Hilary J. Vernon
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-9 (2022)
Abstract Background Natural history studies are increasingly recognized as having an important role in drug development for rare diseases. A phase 3, observational, retrospective, and non-interventional study was designed to establish a natural histo
Externí odkaz:
https://doaj.org/article/e8832bd27a77474bb0ff3589b829e888
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