Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Elaine deLorimier"'
Autor:
Kausiki Datta, Jeremy Copperman, Elaine deLorimier, Melissa N. Hinman, Marina Guenza, J. Andrew Berglund
Myotonic dystrophy type 2 is a genetic neuromuscular disease caused by the expression of expanded CCUG repeat RNAs from the non-coding region of the C CHC-type zinc finger n ucleic acid- b inding p rotein (CNBP) gene. These CCUG repeats bind and sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383f00386ae241e66c25852a26b6d098
https://europepmc.org/articles/PMC5354507/
https://europepmc.org/articles/PMC5354507/
Autor:
Emily E. Reister, Marina Guenza, Elaine deLorimier, Kush Sharma, J. Andrew Berglund, Peter K. Todd, Jeremy Copperman, Leslie A. Coonrod, Alexandria M Taber
Publikováno v:
Nucleic Acids Research
CUG repeat expansions in the 3′ UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into protein–RNA aggregates. Structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87f1fce6fde3a842f1410c4fc6ba3a9
https://doi.org/10.1093/nar/gku941
https://doi.org/10.1093/nar/gku941
Publikováno v:
Protein science : a publication of the Protein Society. 18(1)
Conformational changes play important roles in the regulation of many enzymatic reactions. Specific motions of side chains, secondary structures, or entire protein domains facilitate the precise control of substrate selection, binding, and catalysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::902512fdeb248e4e525d83b2fe80633e
https://pubmed.ncbi.nlm.nih.gov/19177365
https://pubmed.ncbi.nlm.nih.gov/19177365