Výsledky vyhledávání - "Elaine V, Lourenço"

Autor: Elaine V. Lourenço, Gil Amarilyo, Fu-Dong Shi, Antonio La Cava

Publikováno v: The Journal of Immunology. 193:540-543

The proinflammatory activity of IL-17–producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fff208d3c056e2e6c29a3ab7f344319
https://doi.org/10.4049/jimmunol.1400931

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Laquinimod Delays and Suppresses Nephritis in Lupus-Prone Mice and Affects Both Myeloid and Lymphoid Immune Cells

Autor: Maida Wong, Elaine V. Lourenço, Bevra H. Hahn, Brian J. Skaggs, M. Fernando Palma-Diaz

Publikováno v: Arthritis & Rheumatology. 66:674-685

Objective Lupus nephritis depends on autoantibody deposition and activation of multiple immune cell types that promote kidney inflammation, including lymphocytes and monocyte/macrophages. Laquinimod, currently in clinical trials for multiple sclerosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f565e4a13eefa674e7320166fe16bf2
https://doi.org/10.1002/art.38259

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A Panel of Biomarkers Is Associated With Increased Risk of the Presence and Progression of Atherosclerosis in Women With Systemic Lupus Erythematosus

Autor: John FitzGerald, Michael H. Weisman, Brian J. Skaggs, Weng Kee Wong, Bevra H. Hahn, Maureen McMahon, Nagesh Ragavendra, Jennifer M. Grossman, Elaine V. Lourenço, Mihaela Taylor, Karol E. Watson, Lori Sahakian, Alan Gorn, Daniel J. Wallace, Christina Charles-Schoeman, George Karpouzas

Publikováno v: Arthritis & Rheumatology. 66:130-139

Objective An increased frequency of atherosclerosis (ATH) in systemic lupus erythematosus (SLE) is well-documented but not fully explained by the presence of traditional cardiac risk factors. Several nontraditional biomarkers, including proinflammato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21a6b5aa390d86e03b8692e5e100ee55
https://doi.org/10.1002/art.38204

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Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation

Autor: Elaine V. Lourenço, Antonio La Cava, Giuseppe Matarese, Aijing Liu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 113 (2016): 10637–10642. doi:10.1073/pnas.1607101113
info:cnr-pdr/source/autori:Lourenco E.V.; Liu A.; Matarese G.; La Cava A./titolo:Leptin promotes systemic lupus erythematosus by increasing autoantibody production and inhibiting immune regulation/doi:10.1073%2Fpnas.1607101113/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2016/pagina_da:10637/pagina_a:10642/intervallo_pagine:10637–10642/volume:113
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 38

Leptin is an adipocytokine that plays a key role in the modulation of immune responses and the development and maintenance of inflammation. Circulating levels of leptin are elevated in systemic lupus erythematosus (SLE) patients, but it is not clear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846cc7880d733c0f599142247ddd5664
http://hdl.handle.net/11588/670549

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Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice

Autor: Brian J. Skaggs, Elaine V. Lourenço, Bevra H. Hahn

Publikováno v: Lupus. 20:912-920

Therapeutic agents currently in use to treat systemic lupus erythematosus (SLE) are predominantly immunosuppressive agents with limited specificities. Multiple groups, including ours, have illustrated that inducing tolerance in SLE animal models amel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfebf98bc60a9751bbfdb1058f18b10
https://doi.org/10.1177/0961203311398509

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Natural regulatory T cells in autoimmunity

Autor: Antonio La Cava, Elaine V. Lourenço

Publikováno v: Autoimmunity. 44:33-42

The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410af8bbe05985ee255991fac86d2c7d
https://doi.org/10.3109/08916931003782155

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Cutting Edge: Regulatory T Cells Directly Suppress B Cells in Systemic Lupus Erythematosus

Autor: Bevra H. Hahn, Antonio La Cava, Noriko Iikuni, Elaine V. Lourenço

Publikováno v: The Journal of Immunology. 183:1518-1522

In systemic lupus erythematosus (SLE), adaptive CD4+CD25+Foxp3+ regulatory T cells (Tregs) suppress Th cells that help autoantibody (autoAb)-producing B cells. It is not known whether naturally occurring Tregs can directly suppress B cells in SLE wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45ea55b5ed0eaf160278e34905eef401
https://doi.org/10.4049/jimmunol.0901163

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Counterregulation of Th2 immunity by interleukin 12 reduces host defenses against Strongyloides venezuelensis infection

Autor: Lúcia Helena Faccioli, David M. Aronoff, Elaine V. Lourenço, Daniela Carlos, Simone G. Ramos, Marlene Tiduko Ueta, Eleuza Rodrigues Machado, Érika V. G. Silva, Carlos Arterio Sorgi

Publikováno v: Microbes and Infection. 11:571-578

The aim of this study was to investigate the role of interleukin 12 (IL-12) during Strongyloides venezuelensis infection. IL-12(-/-) and wild-type C57BL/6 mice were subcutaneously infected with 1500 larvae of S. venezuelensis. On days 7, 14, and 21 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ca5ae5d89837276075eb34a5e5cb14
https://doi.org/10.1016/j.micinf.2009.03.005

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Myosin Va phosphorylated on Ser1650 is found in nuclear speckles and redistributes to nucleoli upon inhibition of transcription

Autor: Maria Cristina S, Pranchevicius, Munira M A, Baqui, Hellen C, Ishikawa-Ankerhold, Elaine V, Lourenço, Ricardo M, Leão, Silmara R, Banzi, Claudia Tavares, dos Santos, Maria C, Roque-Barreira, Maria Cristina R, Barreira, Enilza M, Espreafico, Roy E, Larson

Publikováno v: Cell Motility and the Cytoskeleton. 65:441-456

Nuclear actin and nuclear myosins have been implicated in the regulation of gene expression in vertebrate cells. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe93cee982abf0f72f4e6a3959440f3
https://doi.org/10.1002/cm.20269

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História Nova do Brasil: revisitando uma obra polêmica

Autor: Elaine V. Lourenço

Publikováno v: Revista Brasileira de História. 28:385-406

Este artigo busca discutir os textos e os propósitos da coleção História Nova do Brasil, produção conjunta do Ministério da Educação e Cultura e do Instituto Superior de Estudos Brasileiros (Iseb) lançada em 1964 e logo abortada pela ditadu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89206062d5a9f78373a85b762894bf1e
https://doi.org/10.1590/s0102-01882008000200006

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