Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Elaine Tung"'
Autor:
Mollie Ranalletta, Kathleen K. Bierilo, Ying Chen, Denise Milot, Qing Chen, Elaine Tung, Caroline Houde, Nadine H. Elowe, Margarita Garcia-Calvo, Gene Porter, Suzanne Eveland, Betsy Frantz-Wattley, Mike Kavana, George Addona, Peter Sinclair, Carl Sparrow, Edward A. O'Neill, Ken S. Koblan, Ayesha Sitlani, Brian Hubbard, Timothy S. Fisher
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2739-2752 (2010)
Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP. To better understand the m
Externí odkaz:
https://doaj.org/article/ba8f1fa1fd444c148814f2a249643d10
Autor:
Joe Clemas, Jerry Andrew Taylor, Feroze Ujjainwalla, Jim Tata, Doris F. Cully, Tom Wisniewski, Wei Tang, Charlene Bopp, Clare London, Andreas Verras, Scott B. Hoyt, Andrea Sok, Elaine Tung, Douglas J. MacNeil, Gaochao Zhou, Amjad Ali, Qing Chen, Gino Salituro, Yusheng Xiong, Daniel R. McMasters, Mary Struthers, Ning Ren, Ruth A. Duffy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2384-2388
We report the discovery and hit-to-lead optimization of a structurally novel indazole series of CYP11B2 inhibitors. Benchmark compound 34 from this series displays potent inhibition of CYP11B2, high selectivity versus related steroidal and hepatic CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f9a114775b2eff2c4ce3ec96aa4668
https://doi.org/10.1016/j.bmcl.2017.04.021
https://doi.org/10.1016/j.bmcl.2017.04.021
Autor:
Chris J. van Koppen, Scott B. Hoyt, Gino Salituro, Elaine Tung, Jim Tata, Joe Clemas, Mark Rosenbach, Jack Gibson, Daphne Szeto, Wei Tang, Andreas Verras, Lee-Yuh Pai, Ning Ren, Carrie Ann Maxwell, Joe Metzger, Jose Castro-Perez, Qing Chen, Lina Yin, Daniel R. McMasters, Yusheng Xiong, Rolf W. Hartmann, Mary Struthers, Gui-Bai Liang, Charlene Bopp, Xiuying Ma, Gaochao Zhou, Richard Hajdu, Tom Wisniewski, Mike E. Lassman, Nicole Buist, Clare London, Andrea Sok, Gail Forrest, Sloan Stribling, Theresa McLaughlin, Qingzhong Hu, Tian-Quan Cai, Whitney Lane Petrilli
Publikováno v:
ACS Medicinal Chemistry Letters. 6:861-865
Hit-to-lead efforts resulted in the discovery of compound 19, a potent CYP11B2 inhibitor that displays high selectivity vs related CYPs, good pharmacokinetic properties in rat and rhesus, and lead-like physical properties. In a rhesus pharmacodynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e60459ea9849aaebdf1fc299badb367
https://doi.org/10.1021/acsmedchemlett.5b00048
https://doi.org/10.1021/acsmedchemlett.5b00048
Autor:
Feroze Ujjainwalla, Charlene Bopp, Carrie Ann Shipley, Yusheng Xiong, Mary Struthers, Bindhu V. Karanam, Clare London, Gaochao Zhou, Ning Ren, Andreas Verras, Andrea Sok, Amjad Ali, Qing Chen, Doris F. Cully, Joseph Clemas, Jack Gibson, James R. Tata, Daniel R. McMasters, Ying Li, Whitney Lane Petrilli, Scott B. Hoyt, Elaine Tung, Ian Knemeyer, Ruth A. Duffy, Wei Tang, Thomas Wisniewski, Douglas J. MacNeil, Gino Salituro
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd54739c1d66c5903e38d15b799bee69
https://pubmed.ncbi.nlm.nih.gov/28105288
https://pubmed.ncbi.nlm.nih.gov/28105288
Autor:
Ying Chen, Ken S. Koblan, Nadine Elowe, Mollie Ranalletta, Brian K. Hubbard, Timothy S. Fisher, Carl P. Sparrow, Ayesha Sitlani, Denise P. Milot, Mike Kavana, Elaine Tung, Gene Porter, Margarita Garcia-Calvo, Kathleen K. Bierilo, Peter J. Sinclair, Qing Chen, George H. Addona, Edward A. O'Neill, Suzanne S. Eveland, Caroline Houde, Betsy Frantz-Wattley
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2739-2752 (2010)
Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP. To better understand the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15197af91112b26ddda16dda937fd8a1
https://doi.org/10.1194/jlr.m007468
https://doi.org/10.1194/jlr.m007468
Autor:
Daphne Szeto, Doris F. Cully, Scott B. Hoyt, Ning Ren, Elaine Tung, Charlene Bopp, Jack Gibson, Gino Salituro, Clare London, Jiaqiang Cai, Amjad Ali, Qing Chen, Andrea Sok, Simone Belshaw, Carrie Ann Maxwell, Mark Rosenbach, Gaochao Zhou, Gail Forrest, Tian-Quan Cai, Daniel R. McMasters, Lee-Yuh Pai, Nelo R. Rivera, Sloan Stribling, Emma Carswell, Richard Hajdu, Robinson John E, Andrew J. Cooke, Jeff Kuethe, Tom Wisniewski, Joe Metzger, Thomas R. Clarkson, Gui-Bai Liang, Mary Struthers, Jim Tata, Mike E. Lassman, Lindsay Brown, Wei Tang, Theresa McLaughlin, Xiuying Ma, Nicole Buist, Kun Liu, Joe Clemas, D. Jonathan Bennett, Andreas Verras, Min K. Park, Yusheng Xiong, John Maclean, Jose Castro-Perez
We report the discovery of a benzimidazole series of CYP11B2 inhibitors. Hit-to-lead and lead optimization studies identified compounds such as 32, which displays potent CYP11B2 inhibition, high selectivity versus related CYP targets, and good pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bdb44414988404f1b182298b88bcd9
https://europepmc.org/articles/PMC4434468/
https://europepmc.org/articles/PMC4434468/
