Výsledky vyhledávání - "Elaine T. Alarid"

Akademický článek

Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells

Autor: Svetlana E. Semina, Purab Pal, Nidhi S. Kansara, Rosemary J. Huggins, Elaine T. Alarid, Geoffrey L. Greene, Jonna Frasor

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)

Abstract Background While estrogen receptor (ER) positive breast tumors generally respond well to endocrine therapy (ET), up to 40% of patients will experience relapse, either while on endocrine therapy or after ET is completed. We previously demonst

Externí odkaz: https://doaj.org/article/5a725f4f8f5b4268a101733cf55d706a

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Akademický článek

Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model

Autor: Molly M. Morgan, Megan K. Livingston, Jay W. Warrick, Eli M. Stanek, Elaine T. Alarid, David J. Beebe, Brian P. Johnson

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Abstract The estrogen receptor (ER) regulates the survival and growth of breast cancer cells, but it is less clear how components of the tissue microenvironment affect ER-mediated responses. We set out to test how human mammary fibroblasts (HMFs) mod

Externí odkaz: https://doaj.org/article/93d31729cd3141899c8dc7350744dfce

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Supplementary Figures 1-6 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Autor: Jonna Frasor, Wilbert Zwart, Sabine C. Linn, Geoffrey L. Greene, Elaine T. Alarid, Marleen Kok, Hugo M. Horlings, Joshua D. Stender, Svitlana D. Brovkovych, Luis H. Alejo, Svetlana E. Semina, Stacey E. P. Joosten, Irida Kastrati

Supplemental Figure 1. Tamoxifen treatment induces expression of NFκBB-related genes. Supplementary Figure 2. Immune cell composition and numbers in the tumor microenvironment do not significantly change upon tamoxifen treatment. Supplementary Figur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0039c4867336c4e21797615e8c21b830
https://doi.org/10.1158/1541-7786.22517821

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Supplemental Table 3 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 3. GSEA enrichment plots

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd6e87afccf94de96a3300f77efba1c
https://doi.org/10.1158/1541-7786.22517824.v1

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Supplemental Table 2 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 2. DE Genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0ff584cec9677b32ba3d9d7d689165
https://doi.org/10.1158/1541-7786.22517827

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Supplemental Table 1 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Table 1. Patient characteristics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5735c9f6f1ae5b7ac1c16ac7670f86f2
https://doi.org/10.1158/1541-7786.22517830

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Supplemental Materials and Methods and Figure Legends from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers

Supplemental Materials and Methods and Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212580fc1d86d3e57783d811a2e882eb
https://doi.org/10.1158/1541-7786.22517833

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Abstract P5-11-01: Identification of novel ER and ER-NFκB driven stem-like cell populations in ER+ breast cancer

Autor: Svetlana E. Semina, Mark Maienschein-Cline, Elaine T. Alarid, Carol A. Sartorius, Jonna Frasor

Publikováno v: Cancer Research. 82:P5-11

Approximately 70% of breast cancers are estrogen receptor (ER) positive and can be treated with endocrine therapy. Unfortunately, 30-40% of tumors will recur, often as therapy-resistant metastatic disease. One contributor to disease recurrence is a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70ed8aab9090fc89bd4fe83e410f6a99
https://doi.org/10.1158/1538-7445.sabcs21-p5-11-01

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Progesterone Receptor–Mediated Regulation of Cellular Glucose and 18F-Fluorodeoxyglucose Uptake in Breast Cancer

Autor: Kelley Salem, Rebecca M Reese, Elaine T Alarid, Amy M Fowler

Publikováno v: Journal of the Endocrine Society. 7

Context Positron emission tomography imaging with 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) is used clinically for initial staging, restaging, and assessing therapy response in breast cancer. Tumor FDG uptake in steroid hormone receptor–positive breas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1439a20b793a1e9a74785201d0c1940
https://doi.org/10.1210/jendso/bvac186

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