Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Elaine Sanij"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly conserved master kinase that regulates cellular metabolism and polarity through a complex signaling network involving AMPK and 12 other AMPK-related kinases. Germlin
Externí odkaz:
https://doaj.org/article/2d9eb9223df44d2c99aa1717a5575061
Autor:
Sean Harrop, Phillip C. Nguyen, David Byrne, Clarissa Wilson, Georgina L. Ryland, Tamia Nguyen, Mary Ann Anderson, Seong Lin Khaw, Michelle Martin, Ing Soo Tiong, Elaine Sanij, Piers Blombery
Publikováno v:
eJHaem, Vol 4, Iss 4, Pp 1105-1109 (2023)
Abstract UBTF tandem duplications are recurrent in adult and paediatric acute myeloid leukaemia and have been reported to be associated with a poor prognosis. Co‐mutations in WT1 and FLT3 are common while morphological dysplasia is frequent. The ro
Externí odkaz:
https://doaj.org/article/2d9d94c1c90646a8aaf70629c552d1da
Autor:
Jian Kang, Natalie Brajanovski, Keefe T. Chan, Jiachen Xuan, Richard B. Pearson, Elaine Sanij
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-22 (2021)
Abstract Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Externí odkaz:
https://doaj.org/article/977bdd4f781a4596b021f41e01e07138
Autor:
Haoran Zhu, Keefe T Chan, Xinran Huang, Carmelo Cerra, Shaun Blake, Anna S Trigos, Dovile Anderson, Darren J Creek, David P De Souza, Xi Wang, Caiyun Fu, Metta Jana, Elaine Sanij, Richard B Pearson, Jian Kang
Publikováno v:
eLife, Vol 11 (2022)
Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation. We previously demonstrated that AKT-induc
Externí odkaz:
https://doaj.org/article/1a069ee3d19e47d0b3a564db5b2cdc6d
Autor:
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz:
https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Acquired drug resistance leads to poor clinical outcome in high grade serous ovarian cancer (HGSOC). We have demonstrated the efficacy of the novel drug CX-5461 in HGSOC is mediated through destabilization of DNA replication forks. The data highlight
Externí odkaz:
https://doaj.org/article/b8b17276c25f459c9586b07e0403f48a
Autor:
Jinbae Son, Katherine M. Hannan, Gretchen Poortinga, Nadine Hein, Donald P. Cameron, Austen R. D. Ganley, Karen E. Sheppard, Richard B. Pearson, Ross D. Hannan, Elaine Sanij
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Hyperactivation of RNA polymerase I (Pol I) transcription of ribosomal RNA (rRNA) genes (rDNA) is a key determinant of growth and proliferation and a consistent feature of cancer cells. We have demonstrated that inhibition of rDNA transcription by th
Externí odkaz:
https://doaj.org/article/d1352252bad3409b96196916aa6676cf
Autor:
Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Around 10% of high-grade serous ovarian carcinomas (HGSOC) harbor BRCA1 promoter methylation, but it is uncertain how it predicts response to PARP inhibition. Here, the authors show that homozygous BRCA1 methylation predicts response to rucaparib whi
Externí odkaz:
https://doaj.org/article/daa72fc740814394b7993401524f3f72
Autor:
Geneviève Pépin, Charlotte Nejad, Jonathan Ferrand, Belinda J. Thomas, H. James Stunden, Elaine Sanij, Chwan-Hong Foo, Cameron R. Stewart, Jason E. Cain, Philip G. Bardin, Bryan R. G. Williams, Michael P. Gantier
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Inflammatory responses, while essential for pathogen clearance, can also be deleterious to the host. Chemical inhibition of topoisomerase 1 (Top1) by low-dose camptothecin (CPT) can suppress transcriptional induction of antiviral and inflamm
Externí odkaz:
https://doaj.org/article/1854a7e1960c44029afa2f6f6b8c9dcb
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 103-105 (2015)
The upstream binding transcription factor (UBTF, also called UBF) is thought to function exclusively in RNA polymerase I (Pol I)-specific transcription of the ribosomal genes. We recently reported in Sanij et al. (2014) [1] that the two isoforms of U
Externí odkaz:
https://doaj.org/article/872212f139584e4f9258920774e2ad59