Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elaine Poncio"'
Autor:
Sarfaraz A. Hasni, Sarthak Gupta, Michael Davis, Elaine Poncio, Yenealem Temesgen-Oyelakin, Philip M. Carlucci, Xinghao Wang, Mohammad Naqi, Martin P. Playford, Rishi R. Goel, Xiaobai Li, Ann J. Biehl, Isabel Ochoa-Navas, Zerai Manna, Yinghui Shi, Donald Thomas, Jinguo Chen, Angélique Biancotto, Richard Apps, Foo Cheung, Yuri Kotliarov, Ashley L. Babyak, Huizhi Zhou, Rongye Shi, Katie Stagliano, Wanxia Li Tsai, Laura Vian, Nathalia Gazaniga, Valentina Giudice, Shajia Lu, Stephen R. Brooks, Meggan MacKay, Peter Gregersen, Nehal N. Mehta, Alan T. Remaley, Betty Diamond, John J. O’ Shea, Massimo Gadina, Mariana J. Kaplan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Increased risk of premature cardiovascular disease in systemic lupus erythematosus (SLE) is not well understood, but in animal models, the Janus kinase inhibitor tofacitinib improves related phenotypes. Here the authors report a Phase 1 double-blind
Externí odkaz:
https://doaj.org/article/8b6b0cd6bcc44990af2223bf0755ce63
Autor:
Sarfaraz Hasni, Yenealem Temesgen-Oyelakin, Michael Davis, Jun Chu, Elaine Poncio, Mohammad Naqi, Sarthak Gupta, Xinghao Wang, Christopher Oliveira, Dillon Claybaugh, Amit Dey, Shajia Lu, Philip Carlucci, Monica Purmalek, Zerai G Manna, Yinghui Shi, Isabel Ochoa-Navas, Jinguo Chen, Amrita Mukherjee, Kyu Lee Han, Foo Cheung, Galina Koroleva, Yasmine Belkaid, John S Tsang, Richard Apps, Donald E Thomas, Theo Heller, Massimo Gadina, Martin P Playford, Xiaobai Li, Nehal N Mehta, Mariana J Kaplan
Publikováno v:
Annals of the Rheumatic Diseases. 81:1576-1584
ObjectivesPremature cardiovascular events in systemic lupus erythematosus (SLE) contribute to morbidity and mortality, with no effective preventive strategies described to date. Immune dysregulation and metabolic disturbances appear to play prominent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cf53502ca543bbc502ad148d8e828d
https://doi.org/10.1136/ard-2022-222658
https://doi.org/10.1136/ard-2022-222658
Autor:
Zerai Manna, Yenealem Temesgen-Oyelakin, Diana Chan, Sarfaraz Hasni, Michael Davis, Elaine Poncio, Sarthak Gupta, Mariana J. Kaplan, Yinghui Shi, Ann Biehl, Sungyoung Auh, Philip M. Carlucci, Meryl Waldman, Nicolas Charles, Juan Rivera, Alice Fike, Barbara Dema, Elizabeth Joyal, James E. Balow, Richard M. Siegel
Publikováno v:
Arthritis Rheumatol
Objective Autoreactive IgE antibodies have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). We hypothesize that omalizumab, a monoclonal antibody binding IgE, may improve SLE activity by reducing type I interferon (IFN) prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54946a88b98b479e3adc6bd81bbb096f
https://doi.org/10.1002/art.40828
https://doi.org/10.1002/art.40828
Autor:
Meggan Mackay, Xinghao Wang, Richard Apps, Rishi R. Goel, Ashley Babyak, Valentina Giudice, Nathalia R Gazaniga, Betty Diamond, Ann Biehl, Martin P. Playford, Stephen R. Brooks, Katie Stagliano, Laura Vian, Peter K. Gregersen, Zerai Manna, Michael Davis, Shajia Lu, Elaine Poncio, Yinghui Shi, Nehal N. Mehta, Xiaobai Li, Yuri Kotliarov, Mohammad Naqi, Angelique Biancotto, Sarfaraz Hasni, Rongye Shi, Yenealem Temesgen-Oyelakin, Jinguo Chen, Donald E Thomas, Isabel Ochoa-Navas, Alan T. Remaley, Sarthak Gupta, Foo Cheung, Massimo Gadina, Huizhi Zhou, Wanxia Li Tsai, Philip M. Carlucci, John J. O'Shea, Mariana J. Kaplan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute to this enhanced CVD risk. In lupus animal models, the Janus kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee9ee9d9e4e4fc34a285087b8e0f4bc
http://hdl.handle.net/11386/4766268
http://hdl.handle.net/11386/4766268
Autor:
Aidan Donnellan, Zerai Manna, Eileen Chu, Isabel Ochoa, Michael Davis, Yenealem Temesgen-Oyelakin, Sarfaraz Hasni, Elaine Poncio, Sarthak Gupta, Marquis Chapman, Jun Chu
Publikováno v:
Poster presentations.
Background The care for patients with lupus is complex as they may exhibit multiple concomitant medical and socioeconomic issues. To address all their needs according to the current guidelines is a daunting task in busy outpatient practices. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be3c597b3cb75fa99ead8fb19b2807a5
https://doi.org/10.1136/lupus-2020-eurolupus.205
https://doi.org/10.1136/lupus-2020-eurolupus.205
Autor:
Philip M. Carlucci, Sarthak Gupta, Barbara Dema, Alice Fike, Mariana J. Kaplan, Sungyoung Auh, Elaine Poncio, Zerai Manna, Gabor G. Illei, Ann Biehl, Nico Charles, Juan Rivera, Elizabeth Joyal, Meryl Waldman, Yenealem Temesgen-Oyelakin, Diana Chan, Richard M. Siegel, Sarfaraz Hasni, Michael Davis, Yinghui Shi, James E. Balow
Publikováno v:
Clinical Trials.
Background Previous evidence indicates a putative pathogenic role for IgE autoantibodies in systemic lupus erythematosus (SLE). We hypothesized that Omalizumab, a monoclonal antibody that binds IgE, will reduce SLE activity by decreasing circulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed3660e4ffa6e77232f643057eb38fa5
https://doi.org/10.1136/lupus-2018-lsm.80
https://doi.org/10.1136/lupus-2018-lsm.80
Autor:
Sarfaraz Hasni, Elaine Poncio, Mariana J. Kaplan, Zerai Manna, Sarthak Gupta, Yenealem Temesgen-Oyelakin, Diana Chan, Michael A. Davis
Publikováno v:
Poster session 7: New drugs and trageted therapy.
Background Studies performed in Lyn-/- mice indicate that IgE autoantibodies induce a lupus nephritis-like disease. In SLE, these autoantibodies are associated with increased disease activity. We propose that omalizumab, a monoclonal antibody that bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd0838ea18613b9b546823eadf8c895
https://doi.org/10.1136/lupus-2018-abstract.184
https://doi.org/10.1136/lupus-2018-abstract.184