Výsledky vyhledávání - "Elaine Pirie"

Akademický článek

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide

Autor: Tatyana Gurlo, Thazha P. Prakash, Zhongying Wang, Maani Archang, Lina Pei, Madeline Rosenberger, Elaine Pirie, Richard G. Lee, Peter C. Butler

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Insulin resistance is the major risk factor for Type 2 diabetes (T2D). In vulnerable individuals, insulin resistance induces a progressive loss of insulin secretion with islet pathology revealing a partial deficit of beta cells and islet amyloid deri

Externí odkaz: https://doaj.org/article/bf1ee849ed3745778fd1c233039aded4

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Akademický článek

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

Autor: Tomohiro Nakamura, Olga A. Prikhodko, Elaine Pirie, Saumya Nagar, Mohd Waseem Akhtar, Chang-Ki Oh, Scott R. McKercher, Rajesh Ambasudhan, Shu-ichi Okamoto, Stuart A. Lipton

Publikováno v: Neurobiology of Disease, Vol 84, Iss , Pp 99-108 (2015)

Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups. For instance, S-nitrosylation regulates enzymatic

Externí odkaz: https://doaj.org/article/f1f59b9dd3d54f7b9aa8622cf6a1bca9

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Akademický článek

Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.

Autor: Elaine Pirie, Shayoni Ray, Calvin Pan, Wuxia Fu, Andrew F Powers, Danielle Polikoff, Colton M Miller, Katrina M Kudrna, Edward N Harris, Aldons J Lusis, Rosanne M Crooke, Richard G Lee

Publikováno v: PLoS Genetics, Vol 14, Iss 10, p e1007732 (2018)

Antisense oligonucleotides (ASOs) have demonstrated variation of efficacy in patient populations. This has prompted our investigation into the contribution of genetic architecture to ASO pharmacokinetics (PK) and pharmacodynamics (PD). Genome wide as

Externí odkaz: https://doaj.org/article/9cee66fed6d64056b5418b20d47786f2

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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell

Publikováno v: Journal of the American Chemical Society. 143:3416-3429

The extra hepatic delivery of antisense oligonucleotides (ASOs) remains a challenge and hampers the widespread application of this powerful class of therapeutic agents. In that regard, pancreatic beta cells are a particularly attractive but challengi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b854feb4ca478194b8ccb06db2a2c928
https://doi.org/10.1021/jacs.0c12043

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Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2′-O-Methoxyethyl Antisense Oligonucleotide

Autor: Aldonis J Lusis, Wuxia Fu, Sebastien A. Burel, Richard G. Lee, Padma Narayanan, Jill Hsiao, Patrick Cauntay, Calvin Pan, Elaine Pirie, Rosanne M. Crooke, Shayoni Ray

Publikováno v: Nucleic Acid Therapeutics. 29:266-277

Although antisense oligonucleotides (ASOs) are well tolerated preclinically and in the clinic, some sequences of ASOs can trigger an inflammatory response leading to B cell and macrophage activatio...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf5e6576d8062be011e42cc45b4324dd
https://doi.org/10.1089/nat.2019.0797

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S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD

Autor: Swagata Ghatak, Tomohiro Nakamura, Xu Zhang, Stuart A. Lipton, Piotr Cieplak, Xuemei Han, Chang-ki Oh, John R. Yates, Henry R. Scott, Fernando J. Martinez, Gene W. Yeo, Amanda K. Deal, Elaine Pirie

Publikováno v: Proc Natl Acad Sci U S A

Rare genetic mutations result in aggregation and spreading of cognate proteins in neurodegenerative disorders; however, in the absence of mutation (i.e., in the vast majority of “sporadic” cases), mechanisms for protein misfolding/aggregation rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b8306a5c570747fd63e7d61865e592
https://doi.org/10.1073/pnas.2021368118

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2066-P: Dyrk1a Antisense Oligonucleotides Conjugated to GLP-1R Agonist Promote Pancreatic Beta-Cell Proliferation

Autor: Adam E. Mullick, Andrew F. Powers, Rosanne M. Crooke, Elaine Pirie, Richard T. Lee, Thazha P. Prakash, Wuxia Fu, Sue Murray

Publikováno v: Diabetes. 69

Loss of functional beta cell mass is a major contributor to the pathogenesis of both type 1 and type 2 diabetes. Enhancing proliferation of existing beta cells in the pancreatic islet is one of the promising approaches for restoring functional beta c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ecda7438563ca80ca41b3d0ffe4793b9
https://doi.org/10.2337/db20-2066-p

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Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS

Autor: Ryan T. Libby, Stuart J Rabin, Ruth Wang, Elaine Pirie, Ranjan Batra, Florian Krach, Anthony Q. Vu, Zacharias Kohl, John Ravits, Gene W. Yeo, Emily C. Wheeler, Michael Baughn, Kasey R. Hutt, María Jesús Delgado Rodríguez, Sandra Diaz-Garcia, Jennifer E. Stauffer, Shahram Saberi, Beate Winner, Assael A. Madrigal

Publikováno v: Acta neuropathologica, vol 136, iss 3

Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive. To identify molecular signatures of sALS we performed genome-wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c8524fa972a3775420f809cbfd797a
https://doi.org/10.1007/s00401-018-1870-7

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Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'

Autor: Elaine, Pirie, Patrick, Cauntay, Wuxia, Fu, Shayoni, Ray, Calvin, Pan, Aldonis J, Lusis, Jill, Hsiao, Sebastien A, Burel, Padma, Narayanan, Rosanne M, Crooke, Richard G, Lee

Publikováno v: Nucleic Acid Ther

Although antisense oligonucleotides (ASOs) are well tolerated preclinically and in the clinic, some sequences of ASOs can trigger an inflammatory response leading to B cell and macrophage activation in rodents. This prompted our investigation into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa5fc5522a7263e993c01496f995593c
https://pubmed.ncbi.nlm.nih.gov/31368839

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2143-P: GLP-1 Conjugation Enhances the Activity of Antisense Oligonucleotides Targeting Islet Amyloid Polypeptide (IAPP) or Kelch-Like ECH Associated Protein 1 (Keap1) in Isolated Pancreatic Islets

Autor: Rosanne M. Crooke, Elaine Pirie, Andrew F. Powers, Richard T. Lee, Sue Murray, Wuxia Fu, Thazha P. Prakash

Publikováno v: Diabetes. 68

The incidence of type 2 diabetes (T2D) is increasing rapidly and is currently one of the 21st century’s major challenges to human health. While T2D has a complex etiology, beta cell dysfunction is widely regarded as a key contributor to T2D disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bdcd22b83217a6e22e8cda3e1a896bc
https://doi.org/10.2337/db19-2143-p

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