Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elaine P. Dopfer"'
Autor:
Elaine P. Dopfer, Frederike A. Hartl, Hans-Heinrich Oberg, Gabrielle M. Siegers, O. Sascha Yousefi, Sylvia Kock, Gina J. Fiala, Beatriz Garcillán, Andrew Sandstrom, Balbino Alarcón, Jose R. Regueiro, Dieter Kabelitz, Erin J. Adams, Susana Minguet, Daniela Wesch, Paul Fisch, Wolfgang W.A. Schamel
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1704-1715 (2014)
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for αβTCR activation. Here, we demonstrate tha
Externí odkaz:
https://doaj.org/article/d96a71cd8e9c4d03be71b8194bfc3b6e
Autor:
Stefan F. Martin, Elaine P. Dopfer, Paul Fisch, Jan Harder, Martin Werner, Hans-Eckart Schaefer, Klaus Schwarz, Myriam Ricarda Lorenz, Nicole Rupp, Petros Christopoulos, Christian Bogdan, Philipp R. Esser, Miroslav Malkovsky, Sylvia Kock, Alexander Marx, Wolfgang W. A. Schamel
Publikováno v:
The Journal of Immunology. 194:3045-3053
The mechanisms underlying thymoma-associated immunodeficiency are largely unknown, and the significance of increased blood γδ Τ cells often remains elusive. In this study we address these questions based on an index patient with thymoma, chronic v
Autor:
Miloslav Suchánek, Irene Arellano, Marek Prouza, Aldo Borroto, Manuel Fuentes, Balbino Alarcón, Elaine P. Dopfer, Alberto Orfao, Wolfgang W. A. Schamel
Publikováno v:
The Journal of Immunology; Vol 190
The Journal of Immunology
Digital.CSIC. Repositorio Institucional del CSIC
instname
The Journal of Immunology
Digital.CSIC. Repositorio Institucional del CSIC
instname
et al.
The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3 after TCR engagement. However, experiments with a knockin mutant bearing an 8-aa replacement of the PRS have indicated that Nc
The adaptor protein Nck is inducibly recruited through its SH3.1 domain to a proline-rich sequence (PRS) in CD3 after TCR engagement. However, experiments with a knockin mutant bearing an 8-aa replacement of the PRS have indicated that Nc
Autor:
Pussadee Paensuwan, Frederike A. Hartl, O. Sascha Yousefi, Jatuporn Ngoenkam, Piyamaporn Wipa, Esmeralda Beck-Garcia, Elaine P. Dopfer, Boonruang Khamsri, Donruedee Sanguansermsri, Susana Minguet, Wolfgang W. Schamel, Sutatip Pongcharoen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(11)
Autor:
Elaine P. Dopfer, Barbara Schöpf, Andrea Kleščová, Marek Prouza, Eva Dengler, Wolfgang W. A. Schamel, Michael Reth, Kerstin Höhne, Christine Louis-Dit-Sully, Miloslav Suchánek
Publikováno v:
Immunology Letters; Vol 130
Immunology Letters
Immunology Letters
The T cell antigen receptor (TCR-CD3) complex contains 12 different cytoplasmic tyrosines, each of which is part of an immunoreceptor tyrosine-based activation motif and thus occurs in similar sequence context. Since phosphorylation of individual tyr
Autor:
Piyamaporn Wipa, Susana Minguet, Frederike A. Hartl, Esmeralda Beck-Garcia, Wolfgang W. A. Schamel, Pussadee Paensuwan, Boonruang Khamsri, Sutatip Pongcharoen, Elaine P. Dopfer, Jatuporn Ngoenkam, Donruedee Sanguansermsri, O. Sascha Yousefi
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(1)
Ligand binding to the TCR causes a conformational change at the CD3 subunits to expose the CD3ε cytoplasmic proline-rich sequence (PRS). It was suggested that the PRS is important for TCR signaling and T cell activation. It has been shown that the p
Autor:
Esmeralda Beck-Garcia, Wolfgang W. A. Schamel, Anna K. Schulze, Nadia Martin-Blanco, Susana Minguet, Thomas Höfer, O. Sascha Yousefi, Frederike A. Hartl, Katharina Beck-García, Eszter Molnar, Raquel Blanco, Aldo Borroto, Elaine P. Dopfer, Anna Morath, Mahima Swamy, Balbino Alarcón
Publikováno v:
Immunity. 44(5)
Summary Signaling through the T cell receptor (TCR) controls adaptive immune responses. Antigen binding to TCRαβ transmits signals through the plasma membrane to induce phosphorylation of the CD3 cytoplasmic tails by incompletely understood mechani
Publikováno v:
Immunity. 35:151-153
The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling b
Autor:
Wolfgang W. A. Schamel, Marek Prouza, Miloslav Suchánek, Elaine P. Dopfer, Aldo Borroto, Balbino Alarcón, Manuel Fuentes, Irene Arellano, Alberto Orfao, Raquel Blanco
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(5)
On TCR ligation, the adaptor Nck is recruited through its src homology 3.1 domain to a proline-rich sequence (PRS) in CD3ε. We have studied the relevance of this interaction for T cell activation in vitro and in vivo by targeting the interaction sit
Autor:
Susana Minguet, Dieter Kabelitz, Hans Heinrich Oberg, Erin J. Adams, Sylvia Kock, O. Sascha Yousefi, José R. Regueiro, Balbino Alarcón, Gabrielle M. Siegers, Elaine P. Dopfer, Beatriz Garcillán, Gina J. Fiala, Frederike A. Hartl, Paul Fisch, Wolfgang W. A. Schamel, Andrew Sandstrom, Daniela Wesch
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
E-Prints Complutense. Archivo Institucional de la UCM
Cell Reports, Vol 7, Iss 5, Pp 1704-1715 (2014)
instname
E-Prints Complutense. Archivo Institucional de la UCM
Cell Reports, Vol 7, Iss 5, Pp 1704-1715 (2014)
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the abTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for abTCR activation. Here, we demonstrate that th