Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elaine O'Loughlin"'
Autor:
Sarah M. Rothman, Keith Q. Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O’Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J. Howell, Joel Klappenbach, Matthew Kennedy, Christian Mirescu
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Background Alzheimer’s disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident wit
Externí odkaz:
https://doaj.org/article/8e009419f5ab45f69aae66002d9935b3
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract Background Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of emotions, and amygda
Externí odkaz:
https://doaj.org/article/28d2519aecd1476a9067ee95cc34ab5f
Autor:
Anna-Mari Karkkainen, Philip Manfre, Elaine O’Loughlin, Juha Kuosmanen, Gonzalo Zeballos Zeballos, Kimmo Lehtimäki, Binod Jacob, Takayuki Tsuchiya, Geoffrey B. Varty, Matthew E. Kennedy, Nicholas T Gatto, Thomas W. Rosahl, Sophia Bardehle, Christian Mirescu, Anjali McCullough
Advances in our understanding of cellular functions and phenotypes in the brain rely on technically robust experimental in vivo models with face validity towards human disease. The cuprizone toxin-induced demyelination model is widely used to investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d07f472de9c117ab0bb2ba15fbe88e
https://doi.org/10.1101/2020.12.17.423334
https://doi.org/10.1101/2020.12.17.423334
Publikováno v:
J Neural Transm (Vienna)
Neuroinflammation is a hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Microglia, the innate immune cells of the CNS, are the first to react to patholog
Publikováno v:
Journal of Neuroscience Research. 94:486-503
The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (deja vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympatheti
Autor:
Pallavi Gandhi, Elaine O’Loughlin, Jacob Marcus, Veeravan Mahadomrongkul, Richard C. Stevens, Jason Da Gilliland, Christopher Ware, Bonnie J. Howell, Keith Q. Tanis, Gonzalo Zeballos Zeballos, Joel A. Klappenbach, Michelle Pearson, Sarah M. Rothman, Christian Mirescu, Matthew E. Kennedy, Roger Smith, Vladislav A. Malkov
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Background Alzheimer’s disease (AD) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (Aβ) known as plaques and intracellular tau tangles. Coincident with the for
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-12 (2017)
Journal of neuroinflammation 14(1), 212 (2017). doi:10.1186/s12974-017-0981-8
Journal of Neuroinflammation
Journal of neuroinflammation 14(1), 212 (2017). doi:10.1186/s12974-017-0981-8
Journal of Neuroinflammation
Background: Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders such as autism and schizophrenia, as well as seizure development. The amygdala is a brain region involved in the regulation of emotions, and amygdalar mald
Autor:
Asaf Madi, Elaine O’Loughlin, Anna Worthmann, Oleg Butovsky, Lien Beckers, Tsuneya Ikezu, Frank L. Heppner, Kristin Hartmann, Vladimir Litvak, Mar Gacias, Markus Glatzel, Zain Fanek, Zachary Humulock, Howard L. Weiner, Susanne Krasemann, Joerg Heeren, Jordi Ochando, Zhiping Weng, Ron Cialic, Christian Haass, Yang Xu, Narghes Calcagno, David M. Holtzman, Tobias Zrzavy, Bogdan Budnik, Cynthia A. Lemere, George Tweet, Hans Lassmann, Scott T. Smith, Hao Chen, Caroline Baufeld, Rachid El Fatimy, David J. Greco, Charlotte Madore, Fargol Mazaheri, Emily C. Tjon, Patricia Conde-Sanroman, Jason D. Ulrich
Publikováno v:
Immunity 47(3), 566-581.e9 (2017). doi:10.1016/j.immuni.2017.08.008
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1c04d37b48c4a61a63dc78d139d1b0
https://pub.dzne.de/record/139513
https://pub.dzne.de/record/139513
Autor:
Didem Göz Aytürk, Elaine O’Loughlin, Oleg Butovsky, Ryan Chrenek, Eugene Drokhlyansky, Constance L. Cepko, Timothy K. Soh, Charlotte Madore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(1)
The brain has a tightly regulated environment that protects neurons and limits inflammation, designated "immune privilege." However, there is not an absolute lack of an immune response. We tested the ability of the brain to initiate an innate immune
Publikováno v:
Cold Spring Harbor Perspectives in Medicine. 8:a028993
Microglia are the resident immune cells that constantly survey the central nervous system. They can adapt to their environment and respond to injury or insult by altering their morphology, phenotype, and functions. It has long been debated whether mi