Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Elaine M. Smolock"'
Autor:
Vyacheslav A. Korshunov, Elaine M. Smolock, Mary E. Wines‐Samuelson, Abrar Faiyaz, Deanne M. Mickelsen, Breandan Quinn, Calvin Pan, George J. Dugbartey, Chen Yan, Marvin M. Doyley, Aldons J. Lusis, Bradford C. Berk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)
Background Carotid artery intima/media thickness (IMT) is a hallmark trait associated with future cardiovascular events. The goal of this study was to map new genes that regulate carotid IMT by genome‐wide association. Methods and Results We induce
Externí odkaz:
https://doaj.org/article/26da8cbb24ac4d5c835b7e9142e7bc5a
Autor:
Sri N. Batchu, Elaine M. Smolock, Igor A. Dyachenko, Arkady N. Murashev, Vyacheslav A. Korshunov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 4, Iss 5, Pp n/a-n/a (2015)
Background Clinical studies suggest that acute inflammation in patients with elevated heart rate (HR) increases morbidity and mortality. The SJL/J (SJL) inbred mouse strain is a unique genetic model that has higher HR and systemic and vascular inflam
Externí odkaz:
https://doaj.org/article/3315521d45424dc18196e5d84cea3b17
Autor:
Bradford C. Berk, George J. Dugbartey, Aldons J. Lusis, Abrar Faiyaz, Vyacheslav A. Korshunov, Chen Yan, Breandan Quinn, Elaine M. Smolock, Deanne Mickelsen, Mary E. Wines‐Samuelson, Calvin Pan, Marvin M. Doyley
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Carotid artery intima/media thickness ( IMT ) is a hallmark trait associated with future cardiovascular events. The goal of this study was to map new genes that regulate carotid IMT by genome‐wide association. Methods and Results We indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7c871769b25907ff83ad114788fbbc
http://europepmc.org/articles/PMC7660849
http://europepmc.org/articles/PMC7660849
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2012)
Contraction of bladder smooth muscle is predominantly initiated by M3 muscarinic receptor-mediated activation of the Gq/11-phospholipase C β-protein kinase C (PKC) and the G12/13-RhoGEF-Rho kinase (ROCK) pathways. However, these pathways and their d
Externí odkaz:
https://doaj.org/article/a6db58d19a044009a600e6cdfb6b64a7
Autor:
Xiaoqun Wang, Syamantak Majumder, Jinjiang Pang, Sharon Senchanthisai, Elaine M. Smolock, Zhaoqiang Cui, Hao Liu, Xiangbin Xu, Bradford C. Berk, Guofu Zhu, Chao Xue, Richard T. Libby, Heidi Coia, Dongyang Jiang
Publikováno v:
Cell Reports. 17(10):2532-2541
The spatiotemporal localization and expression of Dll4 are critical for sprouting angiogenesis. However, the related mechanisms are poorly understood. Here, we show that G-protein-coupled receptor-kinase interacting protein-1 (GIT1) is a robust endog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9052f20d4e5c19595eb1c837d5e70e
Autor:
Nwe Nwe Soe, Mark P. Sowden, Padmamalini Baskaran, Patrizia Nigro, Elaine M. Smolock, Yeonghwan Kim, Bradford C. Berk
Publikováno v:
Cardiovascular Research. 101:444-453
Aims Cyclophilin A (CyPA) is a pro-inflammatory mediator involved in oxidative stress-related cardiovascular diseases. It is secreted from vascular smooth muscle cell (VSMC) in response to reactive oxygen species (ROS) in a highly regulated manner. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bd7abb792f2e22f551745e67b350c5
https://doi.org/10.1093/cvr/cvt268
https://doi.org/10.1093/cvr/cvt268
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:1014-1019
Objective— We demonstrated that inflammatory cells and intima–media thickening are increased in carotids exposed to low-blood flow in the SJL/J (SJL) strain compared with other mouse strains. We hypothesized that the extent of inflammation associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a41bebd9b0bc9156855859c548ecea4
https://doi.org/10.1161/atvbaha.112.301129
https://doi.org/10.1161/atvbaha.112.301129
Autor:
Elaine M. Smolock, Prashanthi Menon, Bradford C. Berk, Chen Yan, Guoyong Yin, Michael J. Zuscik
Publikováno v:
Journal of Cellular Physiology. 225:777-785
G-protein-coupled receptor (GPCR) kinase 2 interacting protein-1 (GIT1) is a scaffold protein expressed in various cell types including neurons, endothelial, and vascular smooth muscle cells. The GIT1 knockout (KO) mouse has a pulmonary phenotype due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f3c80bf0a5416fbcd29e68f8ea388e
https://doi.org/10.1002/jcp.22282
https://doi.org/10.1002/jcp.22282
Autor:
Jing Wang, Elaine M. Smolock, Prashanthi Menon, Jinjiang Pang, Guoyong Yin, Chen Yan, Bradford C. Berk
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1976-1982
Objective— Podosomes, which are actin-rich structures, contribute to cell motility, matrix remodeling, and tissue remodeling. We have shown that G protein–coupled receptor kinase 2–interacting protein 1 (GIT1) colocalizes with podosomes and is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f8b15aaba322082a19aa3c05c3c489
https://doi.org/10.1161/atvbaha.110.212415
https://doi.org/10.1161/atvbaha.110.212415
Publikováno v:
Vascular Pharmacology. 53:185-192
We previously demonstrated that reactive oxygen species (ROS) activate Axl, a receptor tyrosine kinase, resulting in increased survival of rat aortic smooth muscle cells (RASMs). Our experiments in Axl knockout mice showed significant reduction in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3c37b00e8234beb894e68d1f151504
https://doi.org/10.1016/j.vph.2010.07.002
https://doi.org/10.1016/j.vph.2010.07.002