Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Elaine M. Sloand"'
Autor:
Elaine M. Sloand, Matthew J. Olnes, Barbara Weinstein, Colin Wu, Jaroslaw Maciejewski, Phillip Scheinberg, Neal S. Young
Publikováno v:
Haematologica, Vol 95, Iss 3 (2010)
Background Pure red cell aplasia and moderate aplastic anemia are marrow failure states with an immune pathogenesis. Previously, we described short-term improvements in blood counts in two pilot studies treating moderate aplastic anemia (mAA) and pur
Externí odkaz:
https://doaj.org/article/d436493eab174cea81bcc7521da195f2
Autor:
Phillip Scheinberg, Colin O. Wu, Olga Nunez, Priscila Scheinberg, Carol Boss, Elaine M. Sloand, Neal S. Young
Publikováno v:
Haematologica, Vol 94, Iss 3 (2009)
Background We hypothesized that the addition of sirolimus to standard horse antithymocyte globulin (h-ATG) and cyclosporine (CsA) would improve response rates in severe aplastic anemia, due to its complementary and synergistic properties to cyclospor
Externí odkaz:
https://doaj.org/article/74769a1b1ec7435eadf899983919674d
Autor:
Neha Korde, Neal S. Young, Olga Simakova, Andrea Poon, Elaine M. Sloand, Richard W. Childs, Mary Kwok, Ola Landgren, Rene Costello, Pierre Noel, Clifton C. Mo, Yong Zhang, Samuel M. Silver, Kelsey B. Loeliger, Adriana Zingone, Irina Maric
Pure red cell aplasia (PRCA) is a rare disorder characterized by inhibition of erythroid precursors in the bone marrow and normochromic, normocytic anaemia with reticulocytopenia. Among 51 PRCA patients, we identified 12 (24%) patients having monoclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84dc225561258e786d17442a6b5829e
https://europepmc.org/articles/PMC5549779/
https://europepmc.org/articles/PMC5549779/
Autor:
Jerome E. Groopman, Barbara Weinstein, Neal S. Young, Irina Maric, Elaine M. Sloand, Phillip Scheinberg, Minjung Kwak, Francois Wilhelm, Xin Tian, A. Shenoy, Manoj Maniar, Zachary Tucker, Kelsey B. Loeliger, Agnes S. M. Yong, Matthew J. Olnes, Loretta Pfannes
Publikováno v:
Leukemia Research. 36:982-989
We previously demonstrated upregulation of c-myc, survivin, and cyclin D1 in CD34+ bone marrow mononuclear cells (BMMNCs) of patients with trisomy 8 and monosomy 7 myelodysplastic syndromes (MDS). "Knockdown" of cyclin D1 by RNA interference decrease
Autor:
Hesed Padilla-Nash, Phillip Scheinberg, James N. Cooper, Elaine M. Sloand, Rodrigo T. Calado, Colin O. Wu, Neal S. Young, Thomas Ried
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
In cell and animal models, telomere erosion promotes chromosomal instability via breakage-fusion-bridge cycles, contributing to the early stages of tumorigenesis. However, evidence involving short telomeres in cancer development in humans is scarce,
Autor:
Elaine M. Sloand, Loretta Pfannes, Susan F. Leitman, Andrea Poon, Zachary Tucker, Neal S. Young, Susan J. Miranda, Yu Ying Yau, Thomas Ried, Hesed Padilla-Nash, Matthew J. Olnes, Kelsey B. Loeliger
Publikováno v:
Transfusion. 52:537-541
Background—Reports of monosomy 7 in patients receiving granulocyte colony stimulating factor (G-CSF) have raised concerns that this cytokine may promote genomic instability. However, there are no studies addressing whether repeated administration o
Autor:
Elaine M. Sloand, Zachary Tucker, Colin Wu, Emma Gostick, Agnes S. M. Yong, Matthew J. Olnes, A. John Barrett, Valeria Visconte, Loretta Pfannes, Daniel C. Douek, David Price, J. Joseph Melenhorst, Neal S. Young, Phillip Scheinberg, Jason M. Brenchley
Publikováno v:
Blood. 117:2691-2699
Clinical observations and laboratory evidence link bone marrow failure in myelodysplastic syndrome (MDS) to a T cell–mediated immune process that is responsive to immunosuppressive treatment (IST) in some patients. Previously, we showed that trisom
Autor:
A. John Barrett, Barbara Weinstein, A. Shenoy, Elaine M. Sloand, Matthew J. Olnes, Carol Boss, Phillip Scheinberg, Kenneth More, Kelsey B. Loeliger, Neal S. Young, Colin O. Wu
Publikováno v:
Journal of Clinical Oncology. 28:5166-5173
Purpose Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and progression to leukemia. Clinical and experimental evidence suggests an immune-mediated pathophysiology in some patients, in whom immunosuppressive therapy (IS
Autor:
Zachary Tucker, Cynthia E. Dunbar, Rodrigo T. Calado, Xingmin Feng, John Barrett, Jaroslaw P. Maciejewski, Peiman Hematti, Neal S. Young, Loretta Pfannes, Casey Ling, Elaine M. Sloand, Monika Jasek
Publikováno v:
Biology of Blood and Marrow Transplantation. 16:1665-1673
Graft-versus-host disease (GVHD) is a major risk factor for secondary malignancy after hematopoietic stem cell transplantation. Squamous cell carcinoma (SCC) of the skin and mucous membranes are especially frequent in this setting where aneuploidy an
Autor:
Elaine M. Sloand, Austin John Barrett
Publikováno v:
Hematology/Oncology Clinics of North America. 24:331-341
Laboratory evidence and clinical evidence suggest that some patients with myelodysplastic syndrome (MDS) have immunologically mediated disease. This article describes the laboratory evidence supporting a role for the immune system in the marrow failu