Výsledky vyhledávání - "Elaine M. Jennings"

Akademický článek

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

Autor: Joshua C. Zamora, Hudson R. Smith, Elaine M. Jennings, Teresa S. Chavera, Varun Kotipalli, Aleasha Jay, Stephen M. Husbands, Alex Disney, Kelly A. Berg, William P. Clarke

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)

Abstract Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan®). Although naloxone is very effective and has saved many lives, as a competitive antag

Externí odkaz: https://doaj.org/article/e8104eaa003c4a9d96b8c91d703a834c

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The Identification of Human Translational Biomarkers of Neuropathic Pain and Cross-Species Validation Using an Animal Model

Autor: Bethan Young, John Stephenson, Barira Islam, Nikita N. Burke, Elaine M. Jennings, David P. Finn, Patrick C. McHugh

Publikováno v: Molecular Neurobiology. 60:1179-1194

Neuropathic pain is a common chronic condition, which remains poorly understood. Many patients receiving treatment continue to experience severe pain, due to limited diagnostic/treatment management programmes. The development of objective clinical di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ce3807ae3db0981008940ba0fa8aa66
https://doi.org/10.1007/s12035-022-03124-7

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14-3-3γ mediates the long-term inhibition of peripheral kappa opioid receptor antinociceptive signaling by norbinaltorphimine

Autor: Michael J. Wedemeyer, Elaine M. Jennings, Hudson R. Smith, Teresa S. Chavera, Raehannah J. Jamshidi, Kelly A. Berg, William P. Clarke

Publikováno v: Neuropharmacology. 220

Long-term inhibition of kappa opioid receptor (KOR) signaling in peripheral pain-sensing neurons is a potential obstacle for development of peripherally-restricted KOR agonists that produce analgesia. Such a long-term inhibitory mechanism is invoked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc04a03c2e42fe28c0632aef9193591
https://pubmed.ncbi.nlm.nih.gov/36126728

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Autor: Elaine M. Jennings, Laura C. Sullivan, Raehannah J. Jamshidi, Peter M. LoCoco, Hudson R. Smith, Teresa S. Chavera, Kelly A. Berg, William P. Clarke

Publikováno v: Neuropharmacology. 216

Pain and pain management in the elderly population is a significant social and medical problem. Pain sensation is a complex phenomenon that typically involves activation of peripheral pain-sensing neurons (nociceptors) which send signals to the spina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23882e842a6d3dccf36e1d79d8dffde
https://pubmed.ncbi.nlm.nih.gov/35835212

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Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

Autor: Teresa S. Chavera, Aleasha Jay, Kelly A. Berg, Varun Kotipalli, Alex Disney, Hudson R. Smith, Stephen M. Husbands, William P. Clarke, Joshua C. Zamora, Elaine M. Jennings

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 6, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives

Opioid overdose is a leading cause of death in the United States. The only treatment available currently is the competitive antagonist, naloxone (Narcan®). Although naloxone is very effective and has saved many lives, as a competitive antagonist it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f790f3a829c16a53befe3e374099267
https://doi.org/10.1002/prp2.887

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Allosterism within δ Opioid–κ Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of κ Opioid Agonist Efficacy

Autor: Blaine A. Jacobs, William P. Clarke, Kelly A. Berg, Teresa A. Chavera, Elaine M. Jennings, Miryam M. Pando

Publikováno v: Molecular Pharmacology. 93:376-386

There is abundant evidence for formation of G protein coupled receptor heteromers in heterologous expression systems, however, little is known of the function of heteromers in native systems. Heteromers of delta and kappa opioid receptors (DOR-KOR he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aee4d247d11d860c4f1193682c5e42b4
https://doi.org/10.1124/mol.117.109975

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Methocinnamox (MCAM) is a Selective, Long Acting Antagonist at Mu Opioid Receptors In Vitro

Autor: Kelly A. Berg, James H. Woods, Stephen M. Husbands, William P. Clarke, Alex Disney, Elaine M. Jennings, Gail Winger, Varun Kotipalli, Joshua C. Zamora

Publikováno v: The FASEB Journal. 33

The occurrence of opioid overdose is reaching epidemic proportions; an estimated 115 Americans die daily from an opioid overdose. The current pharmacological treatment relies exclusively on naloxon...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75a8a7ae6709b5f5c12d73f83fdc2760
https://doi.org/10.1096/fasebj.2019.33.1_supplement.498.8

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