Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Elaine M. Elder"'
1
Gene transfer to human joints: Progress toward a gene therapy of arthritis
Autor: Elaine M. Elder, Richard Kang, Paul D. Robbins, Steven C. Ghivizzani, Theresa L. Whiteside, James H. Herndon, Christopher H. Evans, Molly T. Vogt, Thomas A. Muzzonigro, Matthew M. Tomaino, Simon C. Watkins, Mary Chester M. Wasko
Publikováno v: Proceedings of the National Academy of Sciences. 102:8698-8703
This article describes the clinical application of gene therapy to a nonlethal disease, rheumatoid arthritis (RA). Intraarticular transfer of IL-1 receptor antagonist (IL-1Ra) cDNA reduces disease in animal models of RA. Whether this procedure is saf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bed72b43cb974ea22880d7ae153ca0
https://doi.org/10.1073/pnas.0502854102
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2
Hippocampal Neurotransplantation Evaluated in the Rat Kainic Acid Epilepsy Model
Autor: Edward C. Dixon, Seung-Jin Choi, Douglas Kondziolka, Jeffrey R. Balzer, Elaine M. Elder, Wendy Fellows-Mayle, Toshinori Hasegawa
Publikováno v: Neurosurgery. 55:191-200
OBJECTIVE: Neurotransplantation has focused on disorders that involve subcortical brain targets. We evaluated the concepts of epileptic focus repair and changes in animal behavior through replacement of lost hippocampal neurons. The safety of hippoca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8282511a757d1130c18ddb01b3aa48a1
https://doi.org/10.1227/01.neu.0000126881.40748.93
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3
Neuronal transplantation for motor stroke: from the laboratory to the clinic
Autor: Douglas Kondziolka, Carolyn C. Meltzer, James Gebel, Lawrence R. Wechsler, Elaine M. Elder, Sharon DeCesare
Publikováno v: Physical Medicine and Rehabilitation Clinics of North America. 14:S153-S160
Laboratory studies have established the potential for neuronal transplantation to be of benefit to patients. Experimental studies in normal animals indicate that brain implantation of neurons seems safe. Implanted neurons integrated with the host bra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d2fbc0bd944a4c8792f033f6f9649a
https://doi.org/10.1016/s1047-9651(02)00057-8
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4
Comparison of K-rasgene mutations in tumour and sputum DNA of patients with lung cancer
Autor: Joel L. Weissfeld, Phouthone Keohavong, Weimin Gao, Elaine M. Elder, Theresa L. Whiteside, Lifang Zhang, Robert Gealy
Publikováno v: Biomarkers. 8:156-161
Mutations in the K-ras gene are frequently found in lung tumours and are implicated in the development of lung cancer. In order to investigate the clinical usefulness of these mutations in lung cancer, we applied a sensitive method to compare mutatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16dbed356e3243650e7ee2dc76a9a27
https://doi.org/10.1080/1354750021000046589
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5
Clonal Human (hNT) Neuron Grafts for Stroke Therapy
Autor: James Gebel, Virginia M.-Y. Lee, Lawrence R. Wechsler, Michael McGrogan, Sharon DeCesare, Douglas Kondziolka, Steven Goldstein, Peter T. Nelson, John Q. Trojanowski, Elaine M. Elder, Alan Jacobs, Paul J. Zhang
Publikováno v: The American Journal of Pathology. 160:1201-1206
Although grafted cells may be promising therapy for stroke, survival of implanted neural cells in the brains of stroke patients has never been documented. Human NT2N (hNT) neurons derived from the NTera2 (NT2) teratocarcinoma cell line were shown to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0052d53e5f1097e04b6910724e61e26
https://doi.org/10.1016/s0002-9440(10)62546-1
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6
Serial [18F]Fluorodeoxyglucose Positron Emission Tomography after Human Neuronal Implantation for Stroke
Autor: Carolyn C. Meltzer, Elaine M. Elder, Victor L. Villemagne, Alan Jacobs, James Gebel, Keith R. Thulborn, Lawrence R. Wechsler, Douglas Kondziolka, Steven Goldstein, Sharon DeCesare
Publikováno v: Neurosurgery. 49:586-592
OBJECTIVE There is no known effective treatment for chronic stroke. In this report, we used positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) to map the metabolic brain response to neuronal cell implantation in the first human neu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18de70b180996fba6b45c34eea337d02
https://doi.org/10.1227/00006123-200109000-00011
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8
Transplantation of cultured human neuronal cells for patients with stroke
Autor: Steven Goldstein, James Gebel, Lawrence R. Wechsler, Carolyn C. Meltzer, Keith R. Thulborn, M. A. Reitman, Elaine M. Elder, Peter J. Jannetta, Sharon DeCesare, Douglas Kondziolka, Michael McGrogan, L. Bynum
Publikováno v: ResearcherID
Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility of human neuronal cellular transplantation in patients with basal gangli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebd15570c99e4e5dc3bb42c7c4bb644
https://doi.org/10.1212/wnl.55.4.565
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