Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elaine M. Conner"'
Autor:
Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Kenneth Weichert, Anton J. Frommelt, Jessica Dong, Xiufeng Wu, Heather Austin, Elaine M. Conner, Jonathan R. Fitchett, Aik Roy Heng, Deepa Balasubramaniam, Mark T. Hilgers, Brian Kuhlman, Stephen J. Demarest
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Recombinant T-cells receptors can redirect naïve T cells but often have low or uneven expression. Here, the authors model mutations in TCR constant domains to increase T cell receptor expression, assembly, and stability and generate bispecific molec
Externí odkaz:
https://doaj.org/article/f7c7bcb62ff841d9828b8f1c2709f751
Autor:
S.J. Demarest, Brian Kuhlman, Anton J. Frommelt, Xiufeng Wu, Deepa Balasubramaniam, Shawn Chang, Karen Froning, Heather Austin, F. Huang, Aik Roy Heng, J.R. Fitchett, Elaine M Conner, Mark T. Hilgers, Kenneth Weichert, Jessica Dong, Arlene Sereno, Jack Maguire
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Recombinant T cell receptors (TCRs) can be used to redirect naïve T cells to eliminate virally infected or cancerous cells; however, they are plagued by low stability and uneven expression. Here, we use molecular modeling to identify mutations in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f527b7d0f3eba9b337adef2c5fa3e7ba
http://europepmc.org/articles/PMC7214467
http://europepmc.org/articles/PMC7214467
Publikováno v:
Biometals
The design, synthesis and activity of polymodal compounds for the treatment of inflammatory bowel disease are reported. The compounds, being based on a metal-Schiff base motif, are designed to degrade during intestinal transit to release the bioactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50028e9ef474fb546e4f4888abddce2
https://doi.org/10.1007/s10534-017-0016-z
https://doi.org/10.1007/s10534-017-0016-z
Autor:
Matthew H. Cato, Parham Ramezani-Rad, James R. Woodgett, John R Apgar, Cindi Chen, Robert J. Benschop, Julia Jellusova, Adam D. Richardson, Robert C. Rickert, Elaine M Conner, Charlotte R Leung
Publikováno v:
Nature immunology
B cells predominate in a quiescent state until an antigen is encountered, which results in rapid growth, proliferation and differentiation of the B cells. These distinct cell states are probably accompanied by differing metabolic needs, yet little is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea87e3d09b6b2240b1230dc0ed962058
https://doi.org/10.1038/ni.3664
https://doi.org/10.1038/ni.3664
Autor:
Diana Isabel Ruiz, Thomas P. Cujec, Elaine M Conner, Mark Dickey, John W. Crissman, Xiufeng Wu, S.J. Demarest, Karen Froning, F. Huang, Raheleh Toughiri
Publikováno v:
mAbs
IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b9e1fea4174d48d9198c798f02a134
http://europepmc.org/articles/PMC5058631
http://europepmc.org/articles/PMC5058631
Autor:
Yue-Wei Qian, Holly E. Careskey, Danise Rogers Subramaniam, Robert J. Konrad, Guoqing Cao, William E. Alborn, Elaine M Conner, Julian Davies
Publikováno v:
Clinical Chemistry. 53:1814-1819
Background: Proprotein convertase subtilisin kexin type 9 (PCSK9) is gaining attention as a key regulator of serum LDL-cholesterol (LDLC). This novel serine protease causes the degradation of hepatic LDL receptors by an unknown mechanism. In humans,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93690d2c8c9373ad3456db57b57bd136
https://doi.org/10.1373/clinchem.2007.091280
https://doi.org/10.1373/clinchem.2007.091280
Autor:
Adam S. Cockrell, Matthew B. Grisham, Shigeyuki Kawachi, Lan Feng, Laura Gray, Robert A. Specian, D. Neil Granger, Elaine M. Conner, Michael Wolcott, Stephen R. Jennings, Zenichi Morise, F. Stephen Laroux, Henri C. van der Heyde, Robert Chervenak
Publikováno v:
Inflammatory Bowel Diseases. 6:171-180
The objectives of this study were to quantify colonic cytokine and endothelial cell adhesion molecule (ECAM) expression in the colons of severe combined immunodeficient (SCID) mice reconstituted with different subsets of CD4+ T lymphocytes. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c958a568c834301eae56f88d74387883
https://doi.org/10.1002/ibd.3780060304
https://doi.org/10.1002/ibd.3780060304
Autor:
Arlene Sereno, Stephen Demarest, Kai Zhang, J.R. Fitchett, Xiufeng Wu, Dongmei He, Heather L Rick, Flora Huang, Elaine M Conner, Micheal A. Batt
Immunoglobulins and T cell receptors (TCRs) share common sequences and structures. With the goal of creating novel bispecific antibodies (BsAbs), we generated chimeric molecules, denoted IgG_TCRs, where the Fv regions of several antibodies were fused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c6f8835fbc6f6607568fbed4c29f26
https://europepmc.org/articles/PMC4623437/
https://europepmc.org/articles/PMC4623437/
Autor:
Catherine Brautigam Beidler, Shannon M Harlan, Derrick R. Witcher, Jeffrey S. Boyles, Bernice Ellis, Robert L. Johnson, Josef G. Heuer, Shaoyou Chu, Elaine M Conner, Ramona J Petrovan, Amita Datta-Mannan, Anja Stauber, Derek D. Yang, Matthew D. Breyer
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 349(2)
At least seven distinct epidermal growth factor (EGF) ligands bind to and activate the EGF receptor (EGFR). This activation plays an important role in the embryo and in the maintenance of adult tissues. Importantly, pharmacologic EGFR inhibition also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf581b2cb8064abc2baf5ad7c91f50e
https://pubmed.ncbi.nlm.nih.gov/24518034
https://pubmed.ncbi.nlm.nih.gov/24518034
Autor:
Elaine M. Conner, Matthew B. Grisham, Zenichi Morise, F. Stephen Laroux, John W. Fuseler, Shigeyuki Kawachi, Laura Gray
Publikováno v:
Biochemical and Biophysical Research Communications. 268:547-552
The objective of this study was to quantify E-selectin surface expression in the colon as well as other tissues in a CD4(+) T-cell model of chronic colitis in mice using the newly developed dual radiolabel monoclonal antibody technique. Male SCID mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becf5a998d7eea106045ec04777e4ea9
https://doi.org/10.1006/bbrc.2000.2175
https://doi.org/10.1006/bbrc.2000.2175