Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elaine M. Bignell"'
Autor:
Margherita Bertuzzi, Gareth J. Howell, Darren D. Thomson, Rachael Fortune-Grant, Anna Möslinger, Patrick Dancer, Norman Van Rhijn, Natasha Motsi, Alice Codling, Elaine M. Bignell
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109939- (2024)
Summary: Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health. The small size of Af spores suggests that interactions with alveolar epithelial cells
Externí odkaz:
https://doaj.org/article/ff7b9b1ee6e3455b85a6661245bccc68
Autor:
Margherita Bertuzzi, Gemma E. Hayes, Uju J. Icheoku, Norman van Rhijn, David W. Denning, Nir Osherov, Elaine M. Bignell
Publikováno v:
Journal of Fungi, Vol 4, Iss 1, p 8 (2018)
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to
Externí odkaz:
https://doaj.org/article/380e5a2b297b453197a97f00366d3ad1
Autor:
Larissa L.H. John, Darren D. Thomson, Tihana Bicanic, Martin Hoenigl, Alistair J.P. Brown, Thomas S. Harrison, Elaine M. Bignell
Candida aurisis an emerging, multi-drug resistant fungal pathogen that causes refractory colonisation and life-threatening invasive nosocomial infections. The high proportion ofC. aurisisolates that display antifungal resistance severely limits treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f87c74a6ce87646f0b534900b4e7ef3
https://doi.org/10.1101/2022.12.16.520848
https://doi.org/10.1101/2022.12.16.520848
Autor:
Fabio, Gsaller, Takanori, Furukawa, Paul D, Carr, Bharat, Rash, Christoph, Jöchl, Margherita, Bertuzzi, Elaine M, Bignell, Michael J, Bromley
Publikováno v:
Antimicrobial agents and chemotherapy. 62(6)
The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat Aspergillus infection. Despite being potent against other fun
Caenorhabditis elegans-Aspergillus fumigatus (Nematode-mould) Model for Study of Fungal Pathogenesis
Autor:
Ikechukwu Okoli, Elaine M. Bignell
Publikováno v:
British Microbiology Research Journal. 7:93-99
Aims : Caenorhabditis elegans nema tode pathosystem has been used to study both bacterial and fungal pathogenesis. Apart from Candida and Cryptococcus , studies using this model for other fungal infections especially filamentous fungi however, are st
Autor:
Alberto Muñoz, Margherita Bertuzzi, Jan Bettgenhaeuser, Nino Iakobachvili, Elaine M Bignell, Nick D Read
Publikováno v:
PLOS ONE, 10(9):e0138008. Public Library of Science
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0138008 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0138008 (2015)
Aspergillus fumigatus is an inhaled fungal pathogen of human lungs, the developmental growth of which is reliant upon Ca2+-mediated signalling. Ca2+ signalling has regulatory significance in all eukaryotic cells but how A. fumigatus uses intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7d53140e801d14bdd2c59bdb45dc2455
https://cris.maastrichtuniversity.nl/en/publications/6f337b0a-1205-458a-baec-dfdb481b208a
https://cris.maastrichtuniversity.nl/en/publications/6f337b0a-1205-458a-baec-dfdb481b208a
Autor:
Elaine M, Bignell
Publikováno v:
Annals of the New York Academy of Sciences. 1273
Adaptation to extracellular pH is a major challenge to fungal pathogens that infect mammalian hosts. Among pH responses mounted by diverse fungal pathogens there is a high degree of molecular conservation. This, coupled with the absence of such signa
Autor:
Thomas, Hartmann, Timothy C, Cairns, Patrick, Olbermann, Joachim, Morschhäuser, Elaine M, Bignell, Sven, Krappmann
Publikováno v:
Molecular microbiology. 82(4)
Moulds are characterized by their saprophytic lifestyle that is based on osmotrophy. Among them, Aspergillus fumigatus has emerged as the leading cause of fungal infections in the presence of an underlying immunodeficiency. To assess the role of its
Autor:
Sven, Krappmann, Elaine M, Bignell, Utz, Reichard, Tom, Rogers, Ken, Haynes, Gerhard H, Braus
Publikováno v:
Molecular microbiology. 52(3)
We have cloned and characterized the Aspergillus fumigatus cpcA gene encoding the transcriptional activator of the cross-pathway control system of amino acid biosynthesis. cpcA encodes a functional orthologue of Saccharomyces cerevisiae Gcn4p. The co
Autor:
Ruth Ashbee, Elaine M. Bignell
Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods