Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Elaine M Walsh"'
Autor:
Yifan Tai, Angela Chow, Seoyoung Han, Courtney Coker, Wanchao Ma, Yifan Gu, Valeria Estrada Navarro, Manoj Kandpal, Hanina Hibshoosh, Kevin Kalinsky, Katia Manova-Todorova, Anton Safonov, Elaine M Walsh, Mark Robson, Larry Norton, Richard Baer, Taha Merghoub, Anup K Biswas, Swarnali Acharyya
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 8, Pp 1957-1980 (2024)
Abstract Acquired resistance to PARP inhibitors (PARPi) remains a treatment challenge for BRCA1/2-mutant breast cancer that drastically shortens patient survival. Although several resistance mechanisms have been identified, none have been successfull
Externí odkaz:
https://doaj.org/article/2b7acab7d8864163a88c5615d51c25ce
Autor:
Elaine M. Walsh, Neha Mangini, John Fetting, Deborah Armstrong, Isaac S. Chan, Roisin M. Connolly, Katie Fiallos, Jennifer Lehman, Raquel Nunes, Dana Petry, Jeffrey Reynolds, Mirat Shah, Karen L Smith, Kala Visvanathan, Josh Lauring, Ben H Park, Vered Stearns, Antonio C. Wolff
Publikováno v:
Clinical Breast Cancer. 22:319-325
Poly-ADP ribose polymerase (PARP) inhibitors (PARPi) are active in patients with germline BRCA1/2 (gBRCA1/2)-mutated breast cancer, accounting for 5% to 10% of all breast cancers. Another 5% to 10% harbor somatic BRCA1/2 (sBRCA1/2) mutations or mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86a6ead16eeae2bd27af6ba396f6db7
https://doi.org/10.1016/j.clbc.2021.12.007
https://doi.org/10.1016/j.clbc.2021.12.007
Autor:
Elaine M Walsh, Ayca Gucalp, Sujata Patil, Marcia Edelweiss, Dara S Ross, Pedram Razavi, Shanu Modi, Neil M Iyengar, Rachel Sanford, Tiffany Troso-Sandoval, Mila Gorsky, Jackie Bromberg, Pamela Drullinsky, Diana Lake, Serena Wong, Patricia DeFusco, Nicholas Lamparella, Ranja Gupta, Tasmila Tabassum, Leigh Ann Boyle, Artavazd Arumov, Tiffany A Traina
Publikováno v:
Cancer Research. 82:P1-14
Background: Chemotherapy remains the mainstay of treatment for early-stage triple negative breast cancer (TNBC), yet targetable drivers of interest are under investigation. A subset of TNBCs express the androgen receptor (AR) and exhibit androgen-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c13cb51455eb77d7eedf06d84d46453
https://doi.org/10.1158/1538-7445.sabcs21-p1-14-03
https://doi.org/10.1158/1538-7445.sabcs21-p1-14-03
Autor:
Christian F. Meyer, Amanda N. Fader, Elaine M. Walsh, Stephanie L. Wethington, Stephanie Gaillard, Deyin Xing, Melissa H. Lippitt
Publikováno v:
JCO Precis Oncol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e36b59f034c8bbe7b7d1c72591664dd
https://doi.org/10.1200/po.20.00189
https://doi.org/10.1200/po.20.00189
Autor:
Joshua Z Drago, Elaine M Walsh, Mithat Gonen, Michael F Berger, Mark E Robson, Sarat Chandarlapaty, Pedram Razavi, Komal Jhaveri
Publikováno v:
Cancer Research. 82:OT2-04
Background: Extended release onapristone (onapristone ER) is a progesterone receptor (PR) antagonist that inhibits hormone-mediated PR activation and stabilizes PR association with corepressors, resulting in an antineoplastic effect when applied alon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b7dd5b80ae4f7744b5ec8ae9a21416f
https://doi.org/10.1158/1538-7445.sabcs21-ot2-04-01
https://doi.org/10.1158/1538-7445.sabcs21-ot2-04-01
Autor:
Elaine M. Walsh, Ayca Gucalp, Sujata Patil, Marcia Edelweiss, Dara S. Ross, Pedram Razavi, Shanu Modi, Neil M. Iyengar, Rachel Sanford, Tiffany Troso-Sandoval, Mila Gorsky, Jacqueline Bromberg, Pamela Drullinsky, Diana Lake, Serena Wong, Patricia Ann DeFusco, Nicholas Lamparella, Ranja Gupta, Tasmila Tabassum, Leigh Ann Boyle, Artavazd Arumov, Tiffany A. Traina
Publikováno v:
Breast cancer research and treatment. 195(3)
Chemotherapy with or without immunotherapy remains the mainstay of treatment for triple-negative breast cancer (TNBC). A subset of TNBCs express the androgen receptor (AR), representing a potential new therapeutic target. This study assessed the feas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2e3c8d641ff0c1453658b5161f94ac
https://pubmed.ncbi.nlm.nih.gov/35986801
https://pubmed.ncbi.nlm.nih.gov/35986801
Publikováno v:
Cancer treatment reviews. 109
The estrogen receptor (ER) is an important driver in the proliferation, tumorigenesis, and progression of breast cancers, and targeting ER signaling at different levels is a successful strategy in the control of hormone receptor positive (HR+) breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de6d3dd254c96c2af1af8e0e012e327
https://pubmed.ncbi.nlm.nih.gov/35839531
https://pubmed.ncbi.nlm.nih.gov/35839531
Publikováno v:
Semin Oncol
The majority of breast cancers are diagnosed at an early stage and are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative. Significant advances have been made in the management of early stage HR-positive, HER2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2228e1854d8b7dde6702a09930c9704b
https://doi.org/10.1053/j.seminoncol.2020.05.010
https://doi.org/10.1053/j.seminoncol.2020.05.010
Autor:
Grace Callagy, Aliaa Shalaby, Michael J. Kerin, Sharon A. Glynn, Maccon M. Keane, Mark O’Loughlin, Mark Webber, Elaine M. Walsh
Publikováno v:
Cancer Research. 80:P1-10
Background: Lymphocyte predominant breast cancers (LPBC) account for 5-30% of TNBCs; 65-80% of TNBCs have low/moderate levels of sTILs and 15-20% have no lymphocyte infiltration. TNBCs with high stromal tumor infiltrating lymphocytes (sTILs) have hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f5f55a7abbdb6701ddbb0b4a0acf2e9
https://doi.org/10.1158/1538-7445.sabcs19-p1-10-11
https://doi.org/10.1158/1538-7445.sabcs19-p1-10-11
Autor:
Lisa Mary Prior, Megan Greally, Patrick G. Morris, Jack Patrick Gleeson, David O'Reilly, Hazel Murray, Rajnish Gupta, Jennifer Westrup, Janice M. Walshe, Razia Aslam, Paul M Walsh, Emmet Jordan, Seamus O'Reilly, M. Higgins, Richard O'Dwyer, Anees Hassan, Deirdre Kelly, Lisa Kiely, Nada Ahmed, Liam Grogan, Marvin Lim, Alfred Ndahi Jones, Linda Coate, John Crown, Elaine M. Walsh, Lillian Smyth, K Duffy, M. John Kennedy, G. Leonard, Oscar S. Breathnach, Paula Calvert, Elly Hanis Che Othman, Abdul R Farooq, Catherine M. Kelly, Giuseppe Gullo, John McCaffrey, Geoffrey Watson, Waseem Darwish, Cian Ward, Connor O'Leary, Miriam O'Connor, Deirdre O'Mahony, Anne M. Horgan, Bryan T. Hennessy, Hannah Featherstone, Desmond N. Carney, M. Keane
Publikováno v:
Breast cancer research and treatment. 189(1)
Pregnancy-associated breast cancer (PABC) is defined as breast cancer diagnosed during the gestational period (gp-PABC) or in the first postpartum year (pp-PABC). Despite its infrequent occurrence, the incidence of PABC appears to be rising due to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d50a148efab3979afa98e6c0e23860c
https://pubmed.ncbi.nlm.nih.gov/34125341
https://pubmed.ncbi.nlm.nih.gov/34125341