Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Elaine M Leslie"'
Autor:
Gurnit Kaur, Elaine M Leslie, Holly Tillman, William M Lee, Diane P Swanlund, Constantine J Karvellas, US Acute Liver Failure Study Group
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139299 (2015)
Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH). Ophthalmic acid (OA) is an analogue of GSH in which cysteine is replaced
Externí odkaz:
https://doaj.org/article/b3eb308a2ca34edcbfa0766ac36c8a32
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Toxicology.
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Toxicology.
Autor:
Michael J. Hafey, Lauren M. Aleksunes, Christy C. Bridges, Kenneth R. Brouwer, Huan‐Chieh Chien, Elaine M. Leslie, Shuiying Hu, Yang Li, Jinshan Shen, Alex Sparreboom, Jason Sprowl, Donald Tweedie, Yurong Lai
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:527-539
Over the last decade, significant progress been made in elucidating the role of membrane transporters in altering drug disposition, with important toxicological consequences due to changes in localized concentrations of compounds. The topic of "Trans
Autor:
Midhat Rizvi, Tina K Truong, Janet Zhou, Manav Batta, Ellen S Moran, John Pappas, Mary Lynn Chu, Oana Caluseriu, Gilad D Evrony, Elaine M Leslie, Emmanuelle Cordat
Publikováno v:
Human molecular genetics.
Congenital myasthenic syndrome (CMS) is a heterogeneous condition associated with 34 different genes, including SLC5A7, which encodes the high-affinity choline transporter 1 (CHT1). CHT1 is expressed in presynaptic neurons of the neuromuscular juncti
Autor:
Jesper Z. Haeggström, Timon Geib, Derek J. Wilson, Vanessa Marensi, Magnus Olsson, Cristina Lento, Elaine M. Leslie, Madhuranayaki Thulasingam, Lekha Sleno
Publikováno v:
Analytical Science Advances. 2:263-271
Autor:
Xiufen Lu, Yingze Ma, Denis Arutyunov, Gurnit Kaur, Janet R. Zhou, X. Chris Le, Elaine M. Leslie
Publikováno v:
Biochemical pharmacology. 193
Millions of people worldwide are exposed to unacceptable levels of arsenic, a proven human carcinogen, in drinking water. In animal models, arsenic and selenium are mutually protective through formation and biliary excretion of seleno-bis (S-glutathi
Publikováno v:
The FASEB Journal. 35
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Current Opinion in Toxicology. 13:90-98
Arsenic is a human carcinogen and is linked to diverse pathologies in many organ systems. Arsenic exposure primarily occurs by ingestion of inorganic arsenic (iAs). Post-ingestion metabolism of iAs involves sequential cellular transformations by the