Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Elaine M, Taylor"'
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181131 (2017)
Acting through a complex signalling network, DNA lesions trigger a range of cellular responses including DNA repair, cell cycle arrest, altered gene expression and cell death, which help to limit the mutagenic effects of such DNA damage. RNA processi
Externí odkaz:
https://doaj.org/article/62ae1f4fa9294b5384d67890ffb204a4
Autor:
Howard D. Lindsay, Andrew J. Green, Irena Stevanovic, Aidan J. Doherty, Sean G. Rudd, Elaine M. Taylor, Julie Bianchi, Laura J. Bailey, Stanislaw K. Jozwiakowski, Violetta Soura, Travis H. Stracker
Publikováno v:
Molecular Cell
Summary DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus, numerous mechanisms exist to complete genome duplication in the absence of a pristine DNA template, but identification of the enzymes involved remains i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649b7cf1541118688f0730b3f0c83aa9
https://doi.org/10.1016/j.molcel.2013.10.035
https://doi.org/10.1016/j.molcel.2013.10.035
Publikováno v:
Nucleic Acids Research
UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various histone marks and interaction with chromatin-modifying proteins. However, its function in regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848381ba2048a5e43899b5a401b099bd
http://europepmc.org/articles/PMC3763540
http://europepmc.org/articles/PMC3763540
Autor:
Elaine M. Taylor, Alan R. Lehmann, Birgit Rathkolb, Limei Ju, Jan Rozman, Johannes Beckers, Martin Hrabě de Angelis, Marion Horsch, Valerie Gailus-Durner, Martin Klingenspor, Thure Adler, Jonathan F. Wing, Predrag Slijepcevic, Andreas Zimmer, Helmut Fuchs, Wolfgang Hans, Lore Becker, Renata M. C. Brandt, Thomas Klopstock, Eckhard Wolf, Gilbertus van der Horst, Ildiko Racz, Dirk H. Busch
Publikováno v:
DNA Repair, 12(5), 356-366. Elsevier
Smc5-6 is a highly conserved protein complex related to cohesin and condensin involved in the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for proliferation and is involved in DNA repair and homologous recombinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f768af24091a1d9121ea3bfbd0c6074a
https://doi.org/10.1016/j.dnarep.2013.02.006
https://doi.org/10.1016/j.dnarep.2013.02.006
Autor:
Thomas A, Guilliam, Nigel C, Brissett, Aaron, Ehlinger, Benjamin A, Keen, Peter, Kolesar, Elaine M, Taylor, Laura J, Bailey, Howard D, Lindsay, Walter J, Chazin, Aidan J, Doherty
Publikováno v:
Nature Communications
DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the presence of such impediments. In addition to translesion synthesis (TLS) polymerases, most euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::063ecee0150004eabcb25edd4d553162
https://pubmed.ncbi.nlm.nih.gov/28534480
https://pubmed.ncbi.nlm.nih.gov/28534480
Autor:
Elaine M. Taylor, Howard D. Lindsay
Publikováno v:
Future oncology (London, England). 12(2)
There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that these cancers rely heavily on replication stress response pathways for their continued proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379831a4984d18f4d56df5bd8c176ce4
https://pubmed.ncbi.nlm.nih.gov/26616915
https://pubmed.ncbi.nlm.nih.gov/26616915
Autor:
Bep Smit, Peter B. Moens, Jennifer H. Lees, Elaine M. Taylor, Jeelan S. Moghraby, Alan R. Lehmann
Publikováno v:
Molecular Biology of the Cell. 12:1583-1594
The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an essential function in DNA replication and mitotic control. It has a heterodimeric partner SMC prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e466dc0395042501d7314ba3733e2041
https://doi.org/10.1091/mbc.12.6.1583
https://doi.org/10.1091/mbc.12.6.1583
Autor:
Elaine M. Taylor, Anthony M. Carr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1378:55-58
This meeting served to juxtapose the fundamental studies on the distinct pathways which maintain genomic stability with work that addresses the phenotypic consequences of loss of genomic stability in humans. This created an exciting environment where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::150dc0e7891917d183c2676d88df1780
https://doi.org/10.1016/s0304-419x(98)00025-0
https://doi.org/10.1016/s0304-419x(98)00025-0
Autor:
Elaine M. Taylor, Alan R. Lehmann
Publikováno v:
International Journal of Radiation Biology. 74:277-286
The fundamental importance of DNA repair for all organisms has become widely acknowledged in recent years. Evidence for the crucial role of DNA repair for the survival of all organisms comes from (1) the diversity of different repair processes; (2) t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ceabc7338afa60c7f25541d56b4e151
https://doi.org/10.1080/095530098141429
https://doi.org/10.1080/095530098141429