Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Elaine L Jacobson"'
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42276 (2012)
Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses. Skin is frequently exposed to the DNA damaging effects of UV irradiation, a known etiology in s
Externí odkaz:
https://doaj.org/article/129f5866fbf14c969b3f62072dc664a1
Autor:
Yira Bermudez, Claudia A Benavente, Ralph G Meyer, W Russell Coyle, Myron K Jacobson, Elaine L Jacobson
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20487 (2011)
Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A an
Externí odkaz:
https://doaj.org/article/0386c41202fa4fc682cc38b22024e4b7
Publikováno v:
Medicinal Chemistry Research. 31:1061-1063
Autor:
Myron K, Jacobson, Elaine L, Jacobson
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1813
This introductory chapter briefly reviews the history, chemistry, and biochemistry of NAD (the term NAD as it is used here refers to both oxidized and reduced forms of the molecule) consuming ADP-ribose transfer enzymes as components of the involveme
Autor:
Elaine L. Jacobson, Myron K. Jacobson
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985876
This introductory chapter briefly reviews the history, chemistry, and biochemistry of NAD (the term NAD as it is used here refers to both oxidized and reduced forms of the molecule) consuming ADP-ribose transfer enzymes as components of the involveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::004a2e303756544e3a712a5e8608d2b7
https://doi.org/10.1007/978-1-4939-8588-3_1
https://doi.org/10.1007/978-1-4939-8588-3_1
Autor:
Margaret M. Briehl, Betty K. Samulitis, Robert T. Dorr, Margaret E. Tome, Donna L. Coyle, Elaine L. Jacobson, Katerina Dvorak, Jennifer B. Frye
Publikováno v:
Experimental and Therapeutic Medicine. 3:845-852
Chronic inflammation increases lymphoma risk. Chronic inflammation exposes cells to increased reactive oxygen species (ROS). Constant exposure to ROS selects for oxidative stress-resistant cells with upregulated anti-oxidant defense enzymes. The impa
Publikováno v:
Current Pharmaceutical Design. 15:29-38
The maintenance and regulation of cellular NAD(P)(H) content and its influence on cell function involves many metabolic pathways, some of which remain poorly understood. Niacin deficiency in humans, which leads to low NAD status, causes sun sensitivi
Publikováno v:
Chromatographia. 68:135-138
Octyl nicotinate is an ester prodrug which is under development for delivery of nicotinic acid to skin for treatment and prevention of dermatological conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or
Autor:
Elaine L. Jacobson, Myron K. Jacobson, Ronald L. Rizer, Hyuntae Kim, W. Russell Coyle, Moonsun Kim, Donna L. Coyle
Publikováno v:
Experimental Dermatology. 16:927-935
Based on the hypothesis that skin barrier impairment is a contributor to side-effects associated with retinoic acid therapy, a double-blind, placebo-controlled pilot study examined the combined use of retinoic acid with myristyl nicotinate (MN), a li