Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Elaine Kay"'
Autor:
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments i
Externí odkaz:
https://doaj.org/article/2aa94f4a6ce8446ea48464a6049912d0
Autor:
Shereen El Mashed, Tracey R. O’Donovan, Elaine Kay, Anthony O’Grady, Damian McManus, Richard C. Turkington, Sharon L. McKenna
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Less than 20 % of patients with resectable oesophageal adenocarcinoma obtain a pathological response following neoadjuvant chemotherapy. Studies using oesophageal cancer cell lines have shown that drug sensitive tumour cells under
Externí odkaz:
https://doaj.org/article/e953a1bbf3464b02bb9dc594e49fa04a
Autor:
David Collie, Steven H. Wright, Jorge del-Pozo, Elaine Kay, Tobias Schwarz, Magdalena Parys, Jessica Lawrence
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Lung is a dose-limiting organ in radiotherapy. This may limit tumour control when effort is made in planning to limit the likelihood of radiation-induced lung injury (RILI). Understanding the factors that dictate susceptibility to radiation-
Externí odkaz:
https://doaj.org/article/0c5d94e24c0d4d5098fd5b1fbe29f23e
Autor:
Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid, Niamh E. Buckley
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treatment options and are
Externí odkaz:
https://doaj.org/article/4531eab64b0f409585612c4bdac7b40f
Autor:
Dominiek Smeets, Ian S. Miller, Darran P. O’Connor, Sudipto Das, Bruce Moran, Bram Boeckx, Timo Gaiser, Johannes Betge, Ana Barat, Rut Klinger, Nicole C. T. van Grieken, Chiara Cremolini, Hans Prenen, Massimiliano Mazzone, Jeroen Depreeuw, Orna Bacon, Bozena Fender, Joseph Brady, Bryan T. Hennessy, Deborah A. McNamara, Elaine Kay, Henk M. Verheul, Neerincx Maarten, William M. Gallagher, Verena Murphy, Jochen H. M. Prehn, Miriam Koopman, Cornelis J. A. Punt, Fotios Loupakis, Matthias P. A. Ebert, Bauke Ylstra, Diether Lambrechts, Annette T. Byrne
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Increased copy number alterations, indicative of chromosomal instability, is associated with poor cancer outcome. Here, metastatic colorectal cancer patients displaying intermediate-high CIN associate with improved outcome following chemotherapy and
Externí odkaz:
https://doaj.org/article/d17fc441244b44c587907023fe2c93dd
Autor:
Lisa Prior, Niamh M Keegan, Simon J Furney, Janice M Walshe, Giuseppe Gullo, John Crown, M John Kennedy, Diarmuid Smith, John McCaffrey, Catherine M Kelly, Keith Egan, Jennifer Kerr, Mark Given, Niall Sheehy, Peter O'Donovan, Andres Hernando, Ausra Teiserskiene, Imelda Parker, Elaine Kay, Ray McDermott, Maccon M Keane, Seamus O'Reilly, Liam Grogan, Oscar Breathnach, Patrick G Morris, Sinead Toomey, Bryan T Hennessy
Publikováno v:
Cancer Research. 82:P5-16
Background: De novo and acquired resistance to HER2 directed therapy is frequently encountered. Upregulation of the phosphatidylinositol-3-kinase (PI3K) pathway is an important mediator of treatment resistance. This can occur through an activating mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f13a61f3e6a988bf98b01cff3e55229d
https://doi.org/10.1158/1538-7445.sabcs21-p5-16-08
https://doi.org/10.1158/1538-7445.sabcs21-p5-16-08
Autor:
Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and
Externí odkaz:
https://doaj.org/article/4cfe33bfecaf449b9233c78e1aecfd67
Autor:
Naomi Elster, Sinead Toomey, Yue Fan, Mattia Cremona, Clare Morgan, Karolina Weiner Gorzel, Una Bhreathnach, Malgorzata Milewska, Madeline Murphy, Stephen Madden, Jarushka Naidoo, Joanna Fay, Elaine Kay, Aoife Carr, Sean Kennedy, Simon Furney, Janusz Mezynski, Oscar Breathhnach, Patrick Morris, Liam Grogan, Arnold Hill, Susan Kennedy, John Crown, William Gallagher, Bryan Hennessy, Alex Eustace
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 10 (2018)
Background: Somatic mutations in the ERBB genes (epidermal growth factor receptor: EGFR, ERBB2, ERBB3, ERBB4 ) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer in vitro . O
Externí odkaz:
https://doaj.org/article/d43fa2bc942c40b9a48533c956583447
Autor:
Damien Coté, Alex Eustace, Sinead Toomey, Mattia Cremona, Malgorzata Milewska, Simon Furney, Aoife Carr, Joanna Fay, Elaine Kay, Susan Kennedy, John Crown, Bryan Hennessy, Stephen Madden
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200996 (2018)
Breast cancer is the leading cause of cancer related deaths in women worldwide and is classified into subtypes based on the cancer's receptor status. Of these subtypes, those expressing the human epidermal growth factor receptor 2 (HER2) receptor wer
Externí odkaz:
https://doaj.org/article/02a9f60a64b34945afcaf15f222ac0e7
Autor:
Imogen Sharkey Ochoa, Esther O’Regan, Mary Toner, Elaine Kay, Peter Faul, Connor O’Keane, Roisin O’Connor, Dorinda Mullen, Mataz Nur, Eamon O’Murchu, Jacqui Barry-O’Crowley, Niamh Kernan, Prerna Tewari, Helen Keegan, Sharon O’Toole, Robbie Woods, Susan Kennedy, Kenneth Feeley, Linda Sharp, Tarik Gheit, Massimo Tommasino, John J. O’Leary, Cara M. Martin
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4321
Peer reviewed: True
Human papillomavirus (HPV) infection has been identified as a significant etiological agent in the development of head and neck squamous cell carcinoma (HNSCC). HPV's involvement has alluded to better survival and prognosis i
Human papillomavirus (HPV) infection has been identified as a significant etiological agent in the development of head and neck squamous cell carcinoma (HNSCC). HPV's involvement has alluded to better survival and prognosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764b105df3a5b1543ab79fc288172f37
https://pubmed.ncbi.nlm.nih.gov/36077856
https://pubmed.ncbi.nlm.nih.gov/36077856