Zobrazeno 1 - 10
of 3 413
pro vyhledávání: '"Elaine K."'
Publikováno v:
Experimental and Molecular Pathology, Vol 139, Iss , Pp 104924- (2024)
Aims: Phytocannabinoids and terpenes from Cannabis sativa have demonstrated limited anti-inflammatory and analgesic effects in several inflammatory conditions. In the current study, we test the hypothesis that phytocannabinoids exert immunomodulatory
Externí odkaz:
https://doaj.org/article/b6081e8f12d84c52abba9e1d3ac4a300
Autor:
Megan H. Hagenauer, Yusra Sannah, Elaine K. Hebda-Bauer, Cosette Rhoads, Angela M. O'Connor, Elizabeth Flandreau, Stanley J. Watson, Jr., Huda Akil
Publikováno v:
MethodsX, Vol 13, Iss , Pp 102788- (2024)
Transcriptional profiling has become a common tool for investigating the nervous system. During analysis, differential expression results are often compared to functional ontology databases, which contain curated gene sets representing well-studied p
Externí odkaz:
https://doaj.org/article/3c68a17835364432afad77bbd564c564
Autor:
Angela May O'Connor, Megan Hastings Hagenauer, Liam Cannon Thew Forrester, Pamela M. Maras, Keiko Arakawa, Elaine K. Hebda-Bauer, Huzefa Khalil, Evelyn R. Richardson, Farizah I. Rob, Yusra Sannah, Stanley J. Watson, Jr., Huda Akil
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100651- (2024)
Stress is a major influence on mental health status; the ways that individuals respond to or copes with stressors determine whether they are negatively affected in the future. Stress responses are established by an interplay between genetics, environ
Externí odkaz:
https://doaj.org/article/e85cafcf63ef498da4d0654c83edcf52
Autor:
Sean McCallion, Thomas McLarnon, Eamonn Cooper, Andrew R. English, Steven Watterson, Melody El Chemaly, Cathy McGeough, Amanda Eakin, Tan Ahmed, Philip Gardiner, Adrian Pendleton, Gary Wright, Declan McGuigan, Maurice O’Kane, Aaron Peace, Ying Kuan, David S. Gibson, Paula L. McClean, Catriona Kelly, Victoria McGilligan, Elaine K. Murray, Frank McCarroll, Anthony J. Bjourson, Taranjit Singh Rai
Publikováno v:
Cells, Vol 13, Iss 19, p 1613 (2024)
Introduction: Cellular senescence is the irreversible growth arrest subsequent to oncogenic mutations, DNA damage, or metabolic insult. Senescence is associated with ageing and chronic age associated diseases such as cardiovascular disease and diabet
Externí odkaz:
https://doaj.org/article/5f393bfa169e4c3a8f6b91c17a4e05b6
Autor:
Thomas McLarnon, Darren McDaid, Seodhna M. Lynch, Eamonn Cooper, Joseph McLaughlin, Victoria E. McGilligan, Steven Watterson, Priyank Shukla, Shu-Dong Zhang, Magda Bucholc, Andrew English, Aaron Peace, Maurice O’Kane, Martin Kelly, Manav Bhavsar, Elaine K. Murray, David S. Gibson, Colum P. Walsh, Anthony J. Bjourson, Taranjit Singh Rai
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1163 (2024)
Background: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has posed unprecedented challenges to healthcare systems worldwide. Here, we have identified proteomic and genetic signatures for improved prognosis which is vital for COV
Externí odkaz:
https://doaj.org/article/a95186f387314385a041feae228bb7a7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract An assessment of the likelihood of use and abuse potential for new tobacco products is an important part of tobacco product regulation in the United States and abroad. This paper reports the results of a randomized, open-label, crossover cli
Externí odkaz:
https://doaj.org/article/17514f223c504f608cab15c51ed012c2
Autor:
Brian M. Keyser, Kyung Soo Hong, Patricia DeLuca, Tao Jin, Bobbette A. Jones, Paul Nelson, Eckhardt Schmidt, Elaine K. Round
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We report the findings from a randomized, parallel study designed to evaluate nicotine pharmacokinetics (PK) following 10 min of ad libitum use of electronic nicotine delivery system (ENDS) in four flavor variants. Subjects were randomized a
Externí odkaz:
https://doaj.org/article/7d10d89c84334401838d12c24b1fe583
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Abuse liability (AL) of electronic nicotine delivery systems (ENDS) is relevant as the category increases in popularity as a potentially less-harmful alternative to cigarette smoking. AL assessments are important to the FDA in determining if
Externí odkaz:
https://doaj.org/article/7dac6979632f4b9cbcd6398f67b4ee0a
Autor:
Milly N. Kanobe, Bobbette A. Jones, Paul Nelson, Buddy G. Brown, Peter Chen, Patrudu Makena, Eckhardt Schmidt, John Darnell, John W. Caraway, G. L. Prasad, Brian Nordskog, Elaine K. Round
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Biomarkers of exposure (BoE) can help evaluate exposure to combustion-related, tobacco-specific toxicants after smokers switch from cigarettes to potentially less-harmful products like electronic nicotine delivery systems (ENDS). This paper
Externí odkaz:
https://doaj.org/article/5711772059b24610b8ba38cc171fdc22
Autor:
Pamela M. Maras, Elaine K. Hebda-Bauer, Megan H. Hagenauer, Kathryn L. Hilde, Peter Blandino, Stanley J. Watson, Huda Akil
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Microglia play critical roles in healthy brain development and function, as well as the neuropathology underlying a range of brain diseases. Despite evidence for a role of microglia in affective regulation and mood disorders, little is known
Externí odkaz:
https://doaj.org/article/519a832fa92a4f8cb02453e2bd418be8