Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elaine J. Derbyshire"'
Publikováno v:
Cell Biophysics. 21:13-23
Ricin A chain ITs directed against a variety of the common cell-surface antigens associated with SCLC exerted selective toxic effects on SCLC cell lines. The potency of the cytotoxic effects matched or exceeded that previously reported for ricin A ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2608e88e808e4715b41e2324ec7c4307
https://doi.org/10.1007/bf02789474
https://doi.org/10.1007/bf02789474
Autor:
Raymond V. Henry, Alan J. Cumber, Elaine J. Derbyshire, Edward J. Wawrzynczak, Norbert Ulbrich, Geoffrey D. Parnell
Publikováno v:
European Journal of Biochemistry. 196:203-209
An immunotoxin was synthesized by the attachment of alpha-sarcin, the ribosome-inactivating protein derived from the mould Aspergillus giganteus, to a monoclonal mouse IgG2 antibody Fib75. The alpha-sarcin immunotoxin exerted toxic effects in tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6af2533599444fe1f4a593c8a4574e
https://doi.org/10.1111/j.1432-1033.1991.tb15805.x
https://doi.org/10.1111/j.1432-1033.1991.tb15805.x
Autor:
Georgina A. Comin, Elaine J. Derbyshire, Philip E. Thorpe, Julian Belloir, Yong Ching Yang, Shuzhen Li
Publikováno v:
Biochimica et biophysica acta. 1310(1)
A new class of angiogenesis inhibitors consist of a non-anticoagulating derivative of heparin, which binds to vascular endothelial cells, coupled to a steriod (e.g., cortisol) which suppresses endothelial cell division. We linked heparin to a further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa6a060d1e9895291a9830a47f51a75
https://pubmed.ncbi.nlm.nih.gov/9244180
https://pubmed.ncbi.nlm.nih.gov/9244180
Autor:
Yong-Ching Yang, Elaine J. Derbyshire, Philip E. Thorpe, Jay P. Overholser, Georgina A. Comin, Linda Watkins
Publikováno v:
International journal of cancer. 63(5)
Heparin-steroid conjugates have been prepared by linking a non-anti-coagulating derivative of heparin, which binds to endothelial cells, to an angiostatic steroid, which suppresses endothelial cell division. One such conjugate, heparin adipic hydrazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f745f7fe23024fa0aa177d90ce62ba
https://pubmed.ncbi.nlm.nih.gov/7591287
https://pubmed.ncbi.nlm.nih.gov/7591287
Publikováno v:
International journal of cancer. 52(4)
Monoclonal antibodies (MAbs) known to recognize epithelial mucin or defined carbohydrate structures present on mucin molecules were screened for their ability to form cytotoxic agents with ricin A-chain active against human small-cell lung cancer (SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500f6e7626af1e7caf6c17f530a91b28
https://pubmed.ncbi.nlm.nih.gov/1328073
https://pubmed.ncbi.nlm.nih.gov/1328073
Publikováno v:
Immunology today. 13(10)
Immunotoxins are hybrid proteins in which the potent cytocidal action of a toxin is harnessed for the selective destruction of target cells by attachment to a specific monoclonal antibody (mAb) or growth factor. This brief article describes the lates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f438a144bef43084e59dd929bfc39f01
https://pubmed.ncbi.nlm.nih.gov/1418372
https://pubmed.ncbi.nlm.nih.gov/1418372
Publikováno v:
Cancer immunology, immunotherapy : CII. 35(6)
The cytotoxic properties of a ricin A chain immunotoxin made with the mouse monoclonal antibody SWA20, recognising a family of sialoglycoprotein antigens selectively expressed by human small-cell lung cancer (SCLC), were examined using a panel of tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4adcc3cf82d55e41ca8199a3c7e4d2
https://pubmed.ncbi.nlm.nih.gov/1327529
https://pubmed.ncbi.nlm.nih.gov/1327529