Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Elaine I, Tuomanen"'
Autor:
Beth Mann, Jeremy Chase Crawford, Kavya Reddy, Josi Lott, Yong Ha Youn, Geli Gao, Cliff Guy, Ching-Heng Chou, Daniel Darnell, Sanchit Trivedi, Perrine Bomme, Allister J. Loughran, Paul G. Thomas, Young-Goo Han, Elaine I. Tuomanen
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Microbial components have a range of direct effects on the fetal brain. However, little is known about the cellular targets and molecular mechanisms that mediate these effects. Neural progenitor cells (NPCs) control the size and architecture
Externí odkaz:
https://doaj.org/article/edfca55a494f487c9d53c10181500628
Autor:
William J. MacCain, Elaine I. Tuomanen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
During acute bacterial meningitis, recognition of the bacterial envelope by immune cells of the central nervous system (CNS) generates a robust response that is essential to clear bacteria. This response is further amplified during treatment when lyt
Externí odkaz:
https://doaj.org/article/f36881389e534561a250a3e5b2e7f6db
Autor:
Elaine I. Tuomanen
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Highly successful invasive pathogens exploit host vulnerabilities by adapting tools to co-opt highly conserved host features. This is especially true when pathogens develop ligands to hijack trafficking routes or signaling patterns of host receptors.
Externí odkaz:
https://doaj.org/article/d12e35fe83444d19a0928fe4f82b2046
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population. Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC)
Externí odkaz:
https://doaj.org/article/72f4ec4bea3149f0934c351d5943b7d6
Publikováno v:
Vaccines, Vol 9, Iss 3, p 209 (2021)
Streptococcus pneumoniae (Spn) is a bacterial pathogen known to colonize the upper respiratory tract and cause serious opportunistic diseases such as pneumonia, bacteremia, sepsis and meningitis. As a consequence, millions of attributable deaths occu
Externí odkaz:
https://doaj.org/article/36cd0dab0eb34458b23bba4c824c9be7
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Pneumococci produce a carbohydrate capsule that protects them against components of the host immune system but sensitizes them to host antimicrobial peptides. Here, Kietzman et al.show that pneumococci respond to antimicrobial peptides by capsule she
Externí odkaz:
https://doaj.org/article/24f047e9b6fb4ce2aae6539763ce00f0
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT The Gram-positive bacterial cell wall (CW) peptidoglycan-teichoic acid complex is released into the host environment during bacterial metabolism or death. It is a highly inflammatory Toll-like receptor 2 (TLR2) ligand, and previous in vivo s
Externí odkaz:
https://doaj.org/article/060763992dfb41f085dc1f6346b57cd1
RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host
Autor:
Erin S. Honsa, Vaughn S. Cooper, Mohammed N. Mhaissen, Matthew Frank, Jessica Shaker, Amy Iverson, Jeffrey Rubnitz, Randall T. Hayden, Richard E. Lee, Charles O. Rock, Elaine I. Tuomanen, Joshua Wolf, Jason W. Rosch
Publikováno v:
mBio, Vol 8, Iss 1 (2017)
ABSTRACT Serious bacterial infections in immunocompromised patients require highly effective antibacterial therapy for cure, and thus, this setting may reveal novel mechanisms by which bacteria circumvent antibiotics in the absence of immune pressure
Externí odkaz:
https://doaj.org/article/51449a358212457e9988f89c165e7419
Autor:
Diego R, Hijano, Zhengming, Gu, Jessica, Brazelton, Haiqing, Zhu, Sri, Suganda, Heather L, Glasgow, Himani, Darji, Li, Tang, Thomas P, Fabrizio, Kim J, Allison, E Kaitlynn, Allen, Aditya H, Gaur, Joshua, Wolf, Paul G, Thomas, Richard J, Webby, Elaine I, Tuomanen
Publikováno v:
Open Forum Infectious Diseases. 9
Although numerous studies have evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection using cycle threshold (Ct) values as a surrogate of viral ribonucleic acid (RNA) load, few studies have used standardized, quantitative me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ddfb6559c4df402e5658ca0383adf3
https://doi.org/10.1093/ofid/ofac490
https://doi.org/10.1093/ofid/ofac490
Autor:
Jason W Rosch, Amy R Iverson, Jessica Humann, Beth Mann, Geli Gao, Peter Vogel, Michael Mina, Kyle A Murrah, Antonia C Perez, W Edward Swords, Elaine I Tuomanen, Jonathan A McCullers
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 1, Pp 141-154 (2013)
Abstract Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of effica
Externí odkaz:
https://doaj.org/article/de0ad90ef07e4977a24c94db68f79a84