Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Elaine Gersz"'
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
G protein-coupled receptors are a major class of drug targets. Here, the authors develop a method whereby their biophysical and functional properties can be altered through directed evolution in mammalian cells, leading to variants exhibiting feature
Externí odkaz:
https://doaj.org/article/b76be3cffcda479f9ff2db12a5dfd09a
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest Smith, Ralf Strohner, Andreas Plückthun
Low stability and poor expression levels are inherent in many G protein-coupled receptors, hindering structural and biophysical analyses. Directed evolution in bacterial or yeast display systems has been successfully used to overcome both limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdab7895d213120ed492900825cbe37
https://doi.org/10.1101/2022.10.17.512578
https://doi.org/10.1101/2022.10.17.512578
Autor:
Suna Onengut-Gumuscu, Rebecca R. Pickin, Maria Faidas, Elaine Gersz, Stephen S. Rich, Noah Vogler
Publikováno v:
Diabetes. 67
Genetic studies of type 1 diabetes (T1D) have identified more than 40 risk loci, yet the causative genes in each locus is widely unknown. Here, we investigated a candidate gene in the 10q23.31 risk locus—FAD-dependent amine oxidase (RNLS). Variants
Autor:
Marsha Raines, Elaine Gersz
Publikováno v:
Neurology Now. 10:54