Zobrazeno 1 - 10 of 157 pro vyhledávání: '"Elaine F F, da Cunha"'
1
Akademický článek
Silver(I) and Copper(II) 1,10-Phenanthroline-5,6-dione Complexes as Promising Antivirulence Strategy against Leishmania: Focus on Gp63 (Leishmanolysin)
Autor: Simone S. C. Oliveira, Claudyane A. Correia, Vanessa S. Santos, Elaine F. F. da Cunha, Alexandre A. de Castro, Teodorico C. Ramalho, Michael Devereux, Malachy McCann, Marta H. Branquinha, André L. S. Santos
Publikováno v: Tropical Medicine and Infectious Disease, Vol 8, Iss 7, p 348 (2023)
Leishmaniasis, caused by protozoa of the genus Leishmania, encompasses a group of neglected diseases with diverse clinical and epidemiological manifestations that can be fatal if not adequately and promptly managed/treated. The current chemotherapy o
Externí odkaz: https://doaj.org/article/6d78d366ea264f1cacf83dd39bd6d1e8
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2
Akademický článek
Exploring EPR Parameters of 187Re Complexes for Designing New MRI Probes: From the Gas Phase to Solution and a Model Protein Environment
Autor: Gustavo A. Andolpho, Elaine F. F. da Cunha, Teodorico C. Ramalho
Publikováno v: Journal of Chemistry, Vol 2022 (2022)
Breast cancer is one of the major types of cancer around the world, and early diagnosis is essential for successful treatment. New contrast agents (CAs), with reduced toxicology, are needed to improve diagnosis. One of the most promising Magnetic Res
Externí odkaz: https://doaj.org/article/5bb7ec96850e429bb77e77837ee21196
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3
Molecular Dynamics-Assisted Interaction of Vanadium Complex–AMPK: From Force Field Development to Biological Application for Alzheimer’s Treatment
Autor: Camila A. Tavares, Taináh M. R. Santos, Elaine F. F. da Cunha, Teodorico C. Ramalho
Publikováno v: The Journal of Physical Chemistry B. 127:495-504
A large part of the world's population is affected by Alzheimer's disease (AD) and diabetes mellitus type 2, which cause both social and economic impacts. These two conditions are associated with one protein, AMPK. Studies have shown that vanadium co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d9101320dc5eee259dafc5c2fede5b
https://doi.org/10.1021/acs.jpcb.2c07147
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4
Akademický článek
Detection of Chemical Weapon Agents Using Spectroscopic Probes: A Computational Study
Autor: Letícia S. Braga, Érika F. Silva, Daiana T. Mancini, Eduardo P. da Rocha, Elaine F. F. da Cunha, Teodorico C. Ramalho
Publikováno v: Journal of Chemistry, Vol 2020 (2020)
Organophosphorus compounds are organic compounds widely employed in agriculture as well as in chemical weapons. The use in agriculture is due to their insecticidal properties. However, in chemical warfare, the use of organophosphorus is associated wi
Externí odkaz: https://doaj.org/article/ede7370a927e4990bce49e9b45af2fbb
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5
Akademický článek
A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase
Autor: Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho
Publikováno v: BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes. Methods To det
Externí odkaz: https://doaj.org/article/ba8425cd990247f4bd02fb26adefa794
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6
Akademický článek
Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target
Autor: Anna Clara M. Galdino, Lívia Viganor, Alexandre A. de Castro, Elaine F. F. da Cunha, Thaís P. Mello, Larissa M. Mattos, Marcos D. Pereira, Mary C. Hunt, Megan O’Shaughnessy, Orla Howe, Michael Devereux, Malachy McCann, Teodorico C. Ramalho, Marta H. Branquinha, André L. S. Santos
Publikováno v: Frontiers in Microbiology, Vol 10 (2019)
Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen Pseudomonas aeruginosa, and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential t
Externí odkaz: https://doaj.org/article/d5bd907c6bd14d5183fd0f1747dd8c52
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9
Akademický článek
Hybrid Materials Based on Magnetic Iron Oxides with Benzothiazole Derivatives: A Plausible Potential Spectroscopy Probe
Autor: Silviana Corrêa, Isael Aparecido Rosa, Gustavo A. Andolpho, Letícia Cristina de Assis, Maíra dos S. Pires, Lívia C. T. Lacerda, Francisco G. E. Nogueira, Elaine F. F. da Cunha, Eugenie Nepovimova, Kamil Kuca, Teodorico C. Ramalho
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8, p 3980 (2021)
Rare diseases affect a small part of the population, and the most affected are children. Because of the low availability of patients for testing, the pharmaceutical industry cannot develop drugs for the diagnosis of many of these orphan diseases. In
Externí odkaz: https://doaj.org/article/5bf4fb86cb884e6b9391b9da348a6cbc
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