Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis.

Autor: Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005432 (2017)

Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes e

Externí odkaz: https://doaj.org/article/4a35b7495b2f4c1d877fe6f8ca6eb7b2

Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate.

Autor: Kingston NJ; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Snowden JS; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Martyna A; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Shegdar M; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Grehan K; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Tedcastle A; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Pegg E; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Fox H; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Macadam AJ; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Martin J; Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK., Hogle JM; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA., Rowlands DJ; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Stonehouse NJ; Astbury Centre for Structural Molecular Biology, School of Molecular & Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Publikováno v: The Journal of general virology [J Gen Virol] 2023 Jun; Vol. 104 (6).

Detection and Typing of Human Enteroviruses from Clinical Samples by Entire-Capsid Next Generation Sequencing.

Autor: Majumdar M; Division of Virology, National Institute for Biological Standards and Control (NIBSC), Potters Bar, Hertfordshire EN6 3QG, UK., Celma C; Enteric Virus Unit, Public Health England, London NW9 5EQ, UK., Pegg E; Division of Virology, National Institute for Biological Standards and Control (NIBSC), Potters Bar, Hertfordshire EN6 3QG, UK., Polra K; Enteric Virus Unit, Public Health England, London NW9 5EQ, UK., Dunning J; Enteric Virus Unit, Public Health England, London NW9 5EQ, UK., Martin J; Division of Virology, National Institute for Biological Standards and Control (NIBSC), Potters Bar, Hertfordshire EN6 3QG, UK.

Publikováno v: Viruses [Viruses] 2021 Apr 08; Vol. 13 (4). Date of Electronic Publication: 2021 Apr 08.

Laboratory Growth and Genetic Manipulation of Eimeria tenella.

Autor: Pastor-Fernández I; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom., Pegg E; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom., Macdonald SE; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom., Tomley FM; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom., Blake DP; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom., Marugán-Hernández V; Department of Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hertfordshire, United Kingdom.

Publikováno v: Current protocols in microbiology [Curr Protoc Microbiol] 2019 Jun; Vol. 53 (1), pp. e81. Date of Electronic Publication: 2019 Feb 27.

Application of a new PCR-RFLP panel suggests a restricted population structure for Eimeria tenella in UK and Irish chickens.

Autor: Pegg E; Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK., Doyle K; Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK., Clark EL; Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK., Jatau ID; Department of Parasitology and Entomology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria., Tomley FM; Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK., Blake DP; Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, North Mymms, AL9 7TA, UK. Electronic address: dblake@rvc.ac.uk.

Publikováno v: Veterinary parasitology [Vet Parasitol] 2016 Oct 15; Vol. 229, pp. 60-67. Date of Electronic Publication: 2016 Sep 26.